dose 2 7

Tag: "dose" at biology news

New view of cancer: 'Epigenetic' changes come before mutations

...pan reported that mice engineered to have a double dose of insulin-like growth factor 2 (IGF2) had more primitive precursor cells in the lining of the colon than normal mice. When these mice also carried a colon-cancer-causing genetic mutation, they developed twice as many tumors as mice with normal IGF2 ...

Reducing antibiotic use lowers rates of drug-resistant bacteria

...the number of prescriptions and, when ordered, the dose and duration of antibiotics, "can induce significant and rapid reductions" of penicillin-resistant pneumococcal colonization in areas that have high rates of drug-resistant bacteria, according to the study. In essence, doctors can make their own jobs...

Chernobyl: The true scale of the accident

...inated areas, exposures are within the recommended dose limit for the general public, though about 100,000 residents still receive more. Remediation of those areas and application of some agricultural countermeasures continues. Further reduction of exposure levels will be slow, but most exposure from the ...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

... respiratory failure. After injecting a very high dose of AAV-8 carrying a normal copy of the delta-sarcoglycan gene intravenously into 10-day-old and adult LGMD hamsters, Dr. Xiao and his colleagues found that it had been systemically incorporated into skeletal, diaphragm and cardiac muscle cells in bot...

Modifications render carbon nanotubes nontoxic

... non-cytotoxic. While cell death did increase with dose concentration, cell death never exceeded 50 percent for these compounds, which were each tested to a level of 2,000 parts per million. Just as with buckyballs, CBEN found that higher degrees of surface modification led to lower toxicity for SWNTs. "...

Prescription pain patch abuse blamed for increase in deaths

...misusing a clear patch that transfers a controlled dose of fentanyl through the skin into the bloodstream ...ng on the drug were able to easily remove the full dose of fentanyl from the patch and take the entire three-day amount at once, either by injecting, ingest...

Old drug shows new promise for Huntington's Disease

...t's a limited study, in that we used the same drug dose on all the animals as opposed to comparing different doses, but fairly convincing," Massa concluded. "Together, the in vitro and in vivo results suggest that Clioquinol has an effect of decreasing the symptoms of Huntington's, its pathology, and perh...

Genetic variation alters response to common anti-clotting drug

...t attack, stroke, or major surgery. But the proper dose of warfarin can vary greatly and can be hard to pr...plain why certain people require a lower or higher dose of warfarin to get its full benefits. This line of work ultimately could help doctors determine each...

Genomics researchers discover protein deficit that causes drug toxicity

...enetic defect, instead of helping heal, a standard dose of thiopurine drugs can cause fatal bone marrow destruction. Though Mayo Clinic researchers described this genetically variable response and the danger it presents over 20 years ago, no one had been able to explain the cellular mechanism behind it. ...

Gaining ground in the race against antibiotic resistance

...yme that allowed the bacteria to survive on a drug dose 64 times higher than the dose that kills bacteria hosting the un-evolved enzyme. "We were mimicking what is going on in the docto...

Hospitalizations because of chicken pox down dramatically since implementation of vaccine

...ost of the vaccine has increased more than $10 per dose in inflation-adjusted terms since 1995 (the current public sector price per dose is $52.25), although an increase of this magnitude was not anticipated to change the cost-effectiven...

Researchers discover new route to hemoglobin synthesis

...but more research is needed using a higher initial dose of opiate, and to examine the effects of phenobarbitone on infant development. In the 1999 U.S. National Household Survey on Drug Abuse, 3.4 percent of pregnant women reported illicit drug use in the past month, which according to authors represents...

Opiates Better Than Sedatives For Treating Newborns In Withdrawal

...but more research is needed using a higher initial dose of opiate, and to examine the effects of phenobarbitone on infant development. In the 1999 U.S. National Household Survey on Drug Abuse, 3.4 percent of pregnant women reported illicit drug use in the past month, which according to authors represents...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...ave undergone gene transfer, four in each of three dose cohorts. Seven of the eight patients representing...to be efficacious, as well as safe, at the current dose levels." This Phase I trial is the culmination of more than 10 years of basic research. In 1994, D...

Structures of marine toxins provide insight into their effectiveness as cancer drugs

...lls. Moreover, initial work shows that even a low dose of these toxins can bring a significant response." Prior to the study published in PNAS, it was known that the marine toxins affect several forms of cancer - but not how they worked, says Rayment. The recent findings will enable the toxins to be syn...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...logical pathway between cells. "We found that one dose of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal said. "If the HO-1 pathway is blocked, the protective effects of IL-10 are lost. The delay in vascular disease shown in this study could ?after more research...

One hit of crystal meth causes birth defects

A single prenatal dose of methamphetamine ?commonly known as speed ?may b...s Wells. "It's pretty remarkable that a single low dose can have such an effect. "It's an important finding, given the increasing use of club drugs among w...

Morphine for Chest Pain Increases Death Risk

...mendation is that patients should receive the full dose of nitroglycerin," he said. "Based on our analysis, morphine should be the last resort after else has been tried." While patients with acute STEMI are at higher risk of dying within 30 days of their hospital stay, patients with non-STEMI actually ha...

Fat's fate depends on its source

A healthy metabolism requires a healthy dose of fat, suggests a new study published in the May issue of Cell Metabolism. Fats taken in directly from the diet or generated from sugars spark a cascade of gene activity in the liver necessary for healthy blood levels of sugar, cholesterol, and othe...

MIT engineers an anti-cancer smart bomb

...into a tumor, seal the exits and detonate a lethal dose of anti-cancer toxins, all while leaving healthy cells unscathed. MIT researchers have designed a nanoparticle to do just that. The dual-chamber, double-acting, drug-packing "nanocell" proved effective and safe, with prolonged survival, against two...

1 2 3 4 5 6 7 8 9