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Tag: "dose" at biology news

Ritalin packs punch by elevating norepinephrine, suppressing nerve signal transmissions

...In addition, the researchers found that the higher dose caused the rats to increase motor activity, while the lower dose did not. Scientists still have much to learn about methylphenidate, which has an impact on neural c...

New device could cut chemotherapy deaths

...py chemical into the cancer site, and a much lower dose to the rest of the body. This is a more localised way of killing cancer cells than the current method of injecting the chemical into a cancer sufferer's vein so that it is carried around the body. As well as reducing the side-effects, the new drug ...

Tetracycline plus teeth equal gray smile

...col involves placing the patient on a prescription dose of fluoride toothpaste for two weeks in order to minimize tooth sensitivity from the whitening solutions. Then, the patient comes in for a one-hour tooth whitening session, where the enamel is painted with the whitening solution and "cured" under a U...

COX-2 inhibitors significantly reduce risk of cancer

...entually, we may find that regular intake of a low dose of a COX-2 inhibitor may be enough to reset the COX-2 cascade and safely protect people against cancer." ...

Weighting cancer drugs to make them hit tumors harder

...e intestines. "Our goal was to increase the tumor dose and lower the systemic dose," said Chilkoti. "Macromolecular drug carriers are an attractive drug delivery system, because they target tumors and have limited toxicity in normal tissues." Of additional benefit, macromolecular drug carriers can be su...

Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients

...otected the neurons against both HIV proteins. The dose of ceftriaxone needed for protection was well within the range currently used for treatment of bacterial infections. "These results indicated that this class of drugs may prove effective in treating HIV patients with dementia," Rumbaugh says. About...

Radiotherapy advance points way to noninvasive brain cancer treatment

...and radiation treatment with the maximum tolerated dose - all of which leads to a painfully low quality of life. Because of this, researchers are racing to find better therapies to stop or slow GBM. In the Jan. 1, 2006 issue of the journal Clinical Cancer Research, Gelsomina "Pupa" De Stasio, professor o...

A step forward in the fight against bacterial infections

...Ghent researchers administered 10 times the lethal dose of LPS to the mutant mice, without deadly consequences. This finding could not be attributed to an alteration in TLR4, but to a reduced production of type 1 interferons. To verify this, Mahieu and her colleagues administered these interferons prevent...

An elephant tail

...were randomly assigned to receive L-arginine (goal dose of 3 g three times a day) or matching placebo for six months. The researchers found: "The VINTAGE MI study demonstrated that 6 months of L-arginine added to standard postinfarct medications did not reduce noninvasive measures of vascular stiffness, ...

Little known DNA repair enzyme may be a tumor suppressor gene

...were randomly assigned to receive L-arginine (goal dose of 3 g three times a day) or matching placebo for six months. The researchers found: "The VINTAGE MI study demonstrated that 6 months of L-arginine added to standard postinfarct medications did not reduce noninvasive measures of vascular stiffness, ...

Use of amino acid supplement following a heart attack provides no benefit, may be harmful

...were randomly assigned to receive L-arginine (goal dose of 3 g three times a day) or matching placebo for six months. The researchers found: "The VINTAGE MI study demonstrated that 6 months of L-arginine added to standard postinfarct medications did not reduce noninvasive measures of vascular stiffness, ...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that ha...nimal model for stroke, researchers administered a dose of 200,000-400,000 human stem cells into the brain of animals that had experienced significant loss ...

Heparin prepared synthetically could replace animal-derived drug

...fficient to treat humans, says Linhardt. One human dose of heparin is approximately 100 milligrams. Rensselaer and UNC-Chapel Hill researchers successfully synthesized hundreds of milligrams of heparin by developing a large-scale process involving engineered enzymes and co-factor recycling. The new, scal...

U-M researchers take new approach to defeating Gram-negative bugs

... was killed with just a fraction of the antibiotic dose typically needed. It was 512 times more susceptible to Rifampin, 256 times more vulnerable to Novobiocin, and eight times more susceptible to Bacitracin, suggesting doses could be dramatically cut and still be effective, Woodard said. Antibiotics typ...

Component in soy products causes reproductive problems in laboratory mice

...effects at all levels. Mice treated with the high dose (Gen 50 mg/kg) were infertile and mice treated with lower doses were subfertile, meaning they had fewer pups in each litter, and fewer pregnancies. Mice receiving the highest level of genistein, 50 mg/kg per day, had a high percentage of egg cells t...

High resolution 'snapshots' detail dynamics of a cocaine antibody

...hand, has the ability to regenerate after each new dose of the drug, making it far more effective than others in metabolizing cocaine. The study, which will be published in the February issue (Volume 14 Issue 2) of the journal Structure, was led by Ian A. Wilson, D.Phil., of Scripps Research Department o...

Scientists develop a way to make the deadliest toxin known even more toxic

...lysis and, unless treated quickly, death. A lethal dose is small--eight tenths of an inhaled microgram for a 175-pound person. Because of its highly potent neurotoxic activity, Janda added, the use of BoNT is also of substantial global concern as a potential bioterrorist weapon. One of the main drawba...

Genomics-based vaccine could prevent deadly cattle disease

...gens and then gave the cattle a potentially lethal dose of T. parva . When compared with control animals, vaccinated cattle showed significantly stronger immune response to the parasite. "This study is a true milestone," says Fraser-Liggett, president of TIGR. "It's one of the first to take advantage o...

New compound protects against liver cancer

...t reduction in pre-cancerous lesions at the lowest dose of 50 micrograms per rat and a 99 percent reduction at the highest dose of 5 milligrams. Like other compounds derived from oleanolic acid, CDDO-Im also has strong anti-inf...

Mice studies illustrate potential of chimp/human antibodies to protect against smallpox

...5 micrograms per mouse--of 8AH8AL or a single 5-mg dose of human VIG (two and a half times the recommended human dose on a weight basis) as a point of comparison. All five mice in the control group died or were sacrifi...

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