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Tag: "dose" at biology news

'Smart' genetic therapy helps the body to heal itself

...rial, based on intramuscular injection of a single dose of an anti-sense drug that induces the skipping of...he muscular dystrophy mouse model to study optimal dose regimes, and further study exon skipping levels. This study found no clinical adverse signs, and t...

Patients to benefit from novel technology revolutionizing high-speed molecular imaging

...and radiation safety standards limit the radiation dose that can be administered for the purpose of diagnostic imaging," said Patton. "In addition to this limitation, the low efficiency of existing SPECT imaging technology in collecting radiation imposes very long acquisition times of up to a full hour an...

New study shows antibiotic may protect the heart

... time that pretreatment with a clinically relevant dose of rapamycin induces a protective effect against heart attack injury and reduces programmed cell death. Researchers believe through the opening of the mitochondrial KATP channel of heart cells, rapamycin enables cells to maintain ATP levels. Mitocho...

Leptin found to control appetite and limb development in frogs

...niversity of Michigan. Denver's team gave frogs a dose of leptin at various stages of development from tadpole to near adult and watched what happened. As in mice, the hormone is apparently a powerful appetite suppressant for these animals, causing them to give up eating even as their bodies waste away. ...

One therapeutic dose of radiation causes 30 percent spongy bone loss in mice

Mice receiving just one therapeutic dose of radiation lost up to 39% of the spongy portion ... Gray (Gy) dose, which is comparable to the single dose of 1-2 Gy that human cancer patients receive. However, cancer patients receive a series of doses ove...

Unique dual target specificity of kinase inhibitor key for success against cancer

...ntly, dual inhibition of p110á and mTOR with a low dose of PI-103 elicited no drug-related toxicity and was highly effective against human gliomas transplanted into mice. "These data suggest that combinatorial inhibition of mTOR and p110á represents a safe and effective therapy in the treatment of cance...

Natural vitamin E tocotrienol reaches blood at protective levels

... Ohio State researchers determined that a moderate dose of tocotrienol reached concentrations in human blood plasma that would be more than adequate to protect against neurological damage that follows stroke. These findings were published in the May issue of the journal Antioxidants & Redox Signaling....

Ultra low-dose estrogen shown safe for post-menopausal women

...andomly assigned to receive a daily .014 milligram dose of either estradiol, a form of estrogen, or a plac...udied by Yaffe and her associates received a daily dose of estradiol ?pure human estrogen ?that was over 44 times smaller and delivered through a skin patch...

Blood test predicts success of quitting smoking using the nicotine patch

... smokers who are likely to benefit from a standard dose of nicotine patch from those who may need a higher dose patch or an alternative therapy in order to succeed in quitting," said lead researcher for the study...

Gene first linked to rare disease may trigger skin cancer, other tumors

...n the nucleus, they found. Treatment with a single dose of ultraviolet light--thought to be a trigger of cylindromas--sparked the same reaction in the mutant cells, they found. "In the absence of CYLD, it is the accumulation of Bcl-3 that is the problem," Fässler said. "Bcl-3 is normally under tight regu...

Injection may prevent infertility in men receiving cancer chemotherapy

...and weighed. The researchers found that a single dose of Taxol had induced significant testicular weight loss compared with the control group. An injection of AS101 a day before that of Taxol prevented the Taxol-induced weight loss. "Tissue analysis of the testes of Taxol-injected mice showed severe...

New GI technologies improve internal organ visualization

...ts (12 colonoscopy and 12 endoscopy) with a single dose of fentanyl as pre-medication, then administered propofol using the CAPS system and its dosing algorithm and safety shell--a control safeguard software program. Data was downloaded from the sedation device to a laptop computer to measure patient res...

Novel therapy combinations gain ground in treating hepatitis

...tion occurred in three patients taking the highest dose (800 mg), forcing the research team to halt the use of that dose and continue using only the lower doses of 200 to 400 mg of the drug. "For patients whose disease h...

Spinal cord bridge bypasses injury to restore mobility

...ule implanted a small pump that delivered a steady dose of chondroitinase to a new incision site near C5 where the researchers hoped to reconnect the other end of the bridge to the spinal cord, but also prevent further scarring. They also primed the newly re-grown axons for rapid regeneration by clipping ...

High-dose flu vaccines appear to safely boost immunity in elderly

...was more common among those who received the 60 ìg dose than among those who received the 15 ìg dose, most...nerable populations," they write. "Increasing the dose of inactivated influenza vaccine consistently and safely increases the immunogenicity [immune respon...

Scientists stop autoimmune disease without shutting off immune system

... the 48 mice used in the study, 24 received a high dose of autoantibody which causes gross blistering akin...o human PV. The other group of 24 received a lower dose that would cause less severe blistering. Half of each group also received treatment with a p38 inhib...

Radiation-armed robot rapidly destroys human lung tumors

...rs which otherwise couldn't be treated with a high dose of radiation due to lack of sufficient real-time tracking accuracy in other, more conventional radiation therapy machines. Treating lung tumors with the enhanced Cyberknife requires only 1-3 sessions lasting 60-90 minutes. In conventional radiother...

Radiation-killed bacteria vaccine induces broad immune response in mice

...cinations, all the mice were infected with a large dose of live Listeria (four times the amount required to kill 50 percent of infected unvaccinated animals). All the unvaccinated mice and all the mice vaccinated with heat-killed Listeria died, but 80 percent of the mice vaccinated with the irradiated ...

Radioactive scorpion venom for fighting cancer

...6 times over 6 weeks. Each group received the same dose of radioactive iodine per week, 40 millicuries (mC...some dose," he says, "but the vast majority of the dose is delivered to the cancer cells." To prevent the radioactive compound from being absorbed by the t...

UF scientists test improved gene therapy method for hereditary heart conditions

...ifference here is that we can deliver a much lower dose of the vector into a vein like any other drug, and...se AAV-9 was so readily taken up by cells, a lower dose likely could be used to achieve a therapeutic effect in people, Byrne said. It also has a unique out...

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