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Tag: "dose" at biology news

Bypassing eggs, flu vaccine grown in insect cells shows promise

..., one-third of the participants received a smaller dose of the vaccine (75 micrograms), one-third received a larger dose (135 micrograms), and one-third received a placebo shot that didn’t include vaccine. Each of the “re...

Misusing vitamin to foil drug test may be toxic; plus, it doesn't work

...hese patients took 300 times the daily recommended dose of niacin." Dr. Mittal added that there is a report in the medical literature of a patient who suffered liver failure, requiring a liver transplant, after taking excessive doses of niacin. Many Internet sites promote the misconception that niacin ...

Xylitol reduces risk of cavities

... to chew gum three times a day, with a total daily dose of 6.0 grams of xylitol. The amount of plaque and... the original levels. Despite the relatively high dose of xylitol used, no negative effects were reported, such as stomach troubles. Products with xylit...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...he clinical trial continues. No maximum tolerated dose has been established, Lu says. The nanoparticle delivery system consists of a plasmid gene expression cassette loaded with DNA that encodes the FUS1 protein. This is wrapped tightly in a form of cholesterol to protect it from the body's defense ...

Researchers discover surprising drug that blocks malaria

...gs in human cell cultures and mice, it reduced the dose of the anti-malarial drugs needed to kill the parasites by tenfold. That's significant because high doses of anti-malarial drugs ?increasingly necessary as resistance to them builds -- can be toxic. In addition, blood pressure medication like propr...

Researchers uncover protection mechanism of radiation-resistant bacterium

...sustain the same amount of DNA damage from a given dose of IR. Additionally, many bacteria are killed by IR doses that actually cause very little DNA damage. In a 2004 study, Daly and colleagues found that resistant and sensitive bacterial cells had significantly different metal concentrations, pointi...

Morphine makes lasting -- and surprising -- change in the brain

... in the brains of rats given as little as a single dose of morphine. The drug’s impact was powerful: LTP continued to be blocked 24 hours later ?long after the drug was out of the animal’s system. "The persistence of the effect was stunning," Kauer said. "This is your brain on drugs." Kauer recorded...

Protein therapy may reduce infarct size in heart attack patients

...e active study drug (KAI-9803) vs. placebo in four dose groups (0.05, 0.5, 1.25 or 5.0 mg of KAI-9803). R...ardial necrosis with lower CK-MB AUC values at all dose levels. Furthermore, improved tissue perfusion (measured during coronary angiography after stent imp...

Fruit fly gene research may shed light on human disease processes

... color blindness or hemophilia, since their double dose of X genetic material helps compensate for 'defective' genes on one of their chromosomes. Men, with just one X chromosome, have less protection. Understanding the role of the X chromosome and the mechanism of chromosome counting in fruit flies may ...

Chemicals in brown algae may protect against skin cancer

...n tumors. The animals fed the lower and the higher dose of BAPs developed an average of 4.7 and 3.7 tumors... given the topical treatment, the lower and higher dose animals had tumors that were 27 percent to 43 percent smaller than animals exposed to UVB alone. ...

Growth hormone to boost athletic performance risks diabetes

...d case of diabetes associated with the use of high dose growth hormone, and urge anyone taking high doses to regularly check their blood sugar levels....

New approach could lower antibiotic requirements by 50 times

... revealed that 75% of those infected with a lethal dose of Pseudomonas survived if the antibiotic gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164). The bacteriophage approach would also be particularly useful for tr...

Nonvenomous Asian snakes 'borrow' defensive poison from toxic toads

...o ward off predators? What if they could borrow a dose of poison by eating toxic toads, then recycling the toxins? That's exactly what happens in the relationship between an Asian snake and a species of toad, according to a team of researchers funded by the National Science Foundation (NSF) Division o...

Dig deeper to find Martian life

...ast five years. The team developed a radiation dose model to study the radiation environment for possible life on Mars. Unlike Earth, Mars is not protected by a global magnetic field or thick atmosphere and for billions of years it has been laid bare to radiation from space. The team quantified how so...

White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

...d closely surround those cells. Third, a lethal dose of each white-blood-cell type's cancer-killing compound is delivered to the cancer cells. The killing molecule varies with the white-cell type. The ordinary mice lack the first two steps. The researchers found that the anti-tumor response involve...

Proteins may predict lung transplant rejection

...s, said Wendt. Doctors may be able to increase the dose of anti-rejection drugs when the early markers of rejection appear. Or, they may reduce anti-rejection drugs for people who do not show early signs of rejection. (Anti-rejection drugs have their own side effects, including an increased chance of deve...

Negative effects of caffeine are stronger on daytime sleep than on nocturnal sleep

...placebo) 3 hours before bedtime, and the remaining dose 1 hour before bedtime. Compared to placebo, caffeine lengthened sleep latency, increased stage 1, and reduced stage 2 and slow-wave sleep (SWS) in both groups. However, caffeine reduced sleep efficiency more strongly in the DayRec group, and decrease...

Preliminary study finds holographic imaging system promising for cancer treatment planning

...appreciation of 3D relationships of anatomical and dose data than images from a flat screen display. According to the study, the location and size of over or under-dosed regions were also easier to identify on Perspecta. The reviewers reported that Perspecta produced a better plan in six out of 12 brain c...

Male contraception: One door opens, another closes

... out the testes, researchers have found that a low dose is both safe and effective in rats. Without this t...esult? Nothing--no effect on fertility, even at a dose high enough to cause diarrhea, stomach upset, and other unpleasant side effects. "We knew it was ...

New brain-chemistry differences found in depressed women

...rst month received a prescription for an increased dose of antidepressant. "Women who had more pronounced responses in their stress response mechanisms during brain imaging also showed alterations in hormones, like cortisol, that are sometimes over-secreted in depression," Zubieta explains. "In additi...

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