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Tag: "disrupted" at biology news

New binding target for oncogenic viral protein

...lular pathways that regulate cell division and are disrupted in cancer. Understanding the mechanisms through which these viruses interact with the cellular machinery that regulates cell division may lead to new insights into the pathways that cause cancer. This is an important step to designing new cancer trea...

Essential mangrove forest threatened by cryptic ecological degradation

...fts in the composition of mangrove tree species to disrupted ethnobiological relationships, lagoon fisheries, and many additional functions provided by mangroves. The authors believe that the worrying aspect of the research is that a degradation of the most vulnerable, most socio-economically important and mo...

Low level of extinction during ice age linked to adaptability

..., driven by the melting and reforming of glaciers, disrupted marine communities, and the ones which survived were those able to adjust. ...

Super predators and mass extinctions

...s and wanes. Inevitably, their stable community is disrupted when mutations lead to a super predator that quickly decimates the prey population, which in turn leads to its own demise. The few creatures that survive the predatory apocalypse gradually mutate to fill the existing ecological niches - and the cycle...

New tumor-suppressor gene discovered

...ent locations along the DNA. The inserted material disrupted the gene's function, which is to make a particular protein that works in particular ways. "A mutant gene is not going to make the protein product that the normal gene is able to make," Lai explains. Lai then generated mutant clones of this fly and f...

15-year hunt finds cause of pseudothalidomide syndrome

...dentical in all the animals contained changes that disrupted the gene's protein-making instructions in people with the syndrome. Knocking out the equivalent gene in yeast and fruit flies led to the same chromosome problems, says Gordillo. "Comparative genomics didn't really exist even five years ago," says Ja...

Alcohol consumption disrupts breastfeeding hormones

... two key hormones that control lactation. Alcohol disrupted release of both hormones during lactation: oxytocin levels decreased an average of 78% and prolactin levels increased by 336%, as compared to when women consumed plain orange juice. Study co-author Yanina Pepino, PhD, a Monell developmental psychobio...

Researcher gets NSF grant to create mutant maize lines

..., but also will create seeds for each mutation, or disrupted gene. The seeds will be made widely available to r...bout this collection is that a single gene will be disrupted in each line while the 50,000 or so other genes are kept exactly the same from seed to seed. A missi...

Fragment of yellow fever virus may hold key to safer vaccine

...Infectious Diseases, a person's own immune system, disrupted by its reaction to yellow fever virus infection, may lead to death rather than recovery. The most recent study was led by Stephane Daffis, a graduate student at Philipps-Universitat in Marburg, Germany. Using blood samples from two yellow fever pati...

Sugar helps control cell division

...t of sugar attached to proteins, the cell cycle is disrupted and isn't salvageable unless O-GlcNAc levels are fixed." In experiments with human cells and mouse cells, Slawson and his colleagues showed that preventing a cell from removing the sugar from proteins causes the cell to copy its genetic material and...

miRNAs and musculature

...nalysis of the mutant larvae after feeding reveals disrupted somatic musculature, strongly suggesting a role for Dmir-1 in the maintenance of muscle integrity and identity in times of stress induced by growth. Dr. Sokol proposes that "Mir-1 could function generally to maintain muscle cell identity by ensuring...

MSKCC researchers uncover structure of key protein complex in cells

... be important in many physiological steps that are disrupted in cancer -- including error-prone DNA replication, chromosome segregation, the cell's response to stress, and normal signaling reactions," said Christopher Lima, PhD, a structural biologist at the Sloan-Kettering Institute and lead author of the stu...

Tsunami + 1 year: Reviving exhausted fisheries should trump replacing boats, gear, experts say

...o the underwater earthquake epicenter, the tsunami disrupted lives in many countries, including Thailand, India, Maldives and Sri Lanka. Officials estimate the total repair cost throughout the affected area at $5.8 billion, while a total of $4.4 billion has been committed to specific projects. There has been...

New view of cancer: 'Epigenetic' changes come before mutations

...g mutation within the population of epigenetically disrupted progenitor cells at the earliest stages of new cell growth, such as the rearrangement of chromosomes in the development of leukemia. This mutation normally has been considered the first step in cancer development. The third step is genetic and epige...

The dangerous legacy of lead

...hich control runaway immune responses ?may also be disrupted by lead exposure in mice. The next step is to understand how this applies to humans. Already, scientists know that lead is toxic to the nervous system and certain regions of the brain. This latest research underscores the burden lead may pose to man...

Bugs expose underground carbon traffic system 10 times more important than fossil fuel burning

...nsumption of the arbulscar mycorrhizal mycelia had disrupted a key pathway transporting carbon from plants to soil. As a final check the researchers examined both the cores with and without Collembola for a particular phospholipid fatty acid (PLFA) that is characteristic for AM mycelia. They found that this...

Switching to new anti-bacterial targets: Riboswitches

...switch controlling vitamin B1 (thiamine) levels is disrupted in the presence of pyrithiamine, a toxic compound related to the vitamin. Bacteria and fungi fail to grow in pyrithiamine and become resistant by acquiring mutations in their riboswitches. This work, in combination with the recently solved crystal s...

How the neuron sprouts its branches

...tal neuronal function." Finally, the researchers disrupted the orientation, or "polarity," of the Golgi -- thus causing them to move into all the dendrites -- without disrupting their function. They found that disrupting the polarity caused all the dendrites to grow at the same rate. Further studies, said E...

UCSD study finds anthrax toxins also harmful to fruit flies

... of embryos and adults. This developmental process disrupted by LF treatment is similar mechanistically to wound healing, which is mediated by the same signaling pathway in humans. The EF toxin is also lethal when applied to fly larvae and can cause severe malformation in the wings of adult fruit flies--an ef...

Activation of a protein solidifies fear memory in the brain

...memory. Conversely, inhibiting PKA in the amygdala disrupted memory reconsolidation. "These findings show bidirectional behavioral plasticity after memory retrieval," Taylor said. "Moreover, we find that amygdalar PKA activation does not affect other memory processes after retrieval, including extinction of f...

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