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Tag: "disrupt" at biology news

Leukemic cells find safe haven in bone marrow

.... "This insight will help researchers find ways to disrupt this safe haven for leukemic cells that need aspar...ecreased by cancer drugs that are already known to disrupt the activity of those cells. "Because asparaginase is so widely used to treat ALL, this new insi...

Salamanders suffer delayed effects of common herbicide

...cide is an endocrine disruptor. Such chemicals disrupt the production of hormones that are vital to normal bodily functions. Concentrations of atrazine as low as 0.1 parts per billion have been shown to cause male frogs to develop both male and female organs by altering their production of sex hormones. ...

Hay fever can send work productivity down the drain

...due to allergy symptoms. Hay fever symptoms can disrupt all areas of life, and study participants cited a lack of sleep and a negative impact on their overall health as the two main reasons for missing work. Szeinbach suggests that people who suspect they have hay fever get an allergy test, either from...

Stem cell therapy shows promise for rescuing deteriorating vision

...ey survive in the environment of the eye and don't disrupt the local architecture. They seem to live in a symbiotic relation ship" with retinal cells. Gamm and Lund emphasize that the new work is preliminary, and that much remains to be done before the cells can be tested in humans: "The first thing is to...

New approach could lower antibiotic requirements by 50 times

...use the lower doses of antibiotic needed would not disrupt the friendly bacteria in the gut - a big problem with conventional antibiotic treatments. 'The prospect of using such treatments to prolong the life of existing agents and delay the onset of widespread resistance is to be welcomed,' said Jim Spence...

New fMRI technology making brain tumor surgery safer

...ections between different parts of a house. If you disrupt that connection, you have no communication between those two areas.? FMRI scans are performed several days prior to surgery on a 3 Tesla scanner at West Image, a Cincinnati imaging facility owned by Set Shababian, M.D. “We perform various langua...

Origin of inherited pain disorder pinpointed

...ontrast to PEPD, which is caused by mutations that disrupt inactivation the sodium channel, PE arises from mutations that lower its activation threshold. The researchers concluded that their findings "further emphasize the critical role of [this sodium channel] in human inflammatory pain and explain the di...

Sensory feedback during speech: The brain attunes to more than just sound

...nt points during speech, but did not significantly disrupt the acoustic quality of the words being spoken. The researchers were able to manipulate jaw motion at specific points during speaking and were thereby able to specifically target vowel or consonant sounds to study whether the production of certain ty...

Study illuminates how the plague bacteria causes disease

...vity reduce but do not eliminate YpkA's ability to disrupt cell shape by modifying their cytoskeletal support... with a critical role in the bacteria's ability to disrupt cell structure. The domain paralyzes cells by acting as an "off-switch" for host proteins involved i...

From a lowly yeast, researchers divine a clue to human disease

... too much or too little genetic information -- can disrupt the normal functions of cells and, in some cases, lead to disease. Sen1 mutations are likely to have similar effects in humans, says Brow. By adapting his approach, other researchers may be able to identify specific genes affected in the human Sen1...

New sunscreen ingredient to heal sunburn and help prevent skin cancer

... free radicals and DNA, causing mutations that can disrupt the cell cycle and potentially lead to cancer. "We wanted to find a way of mopping up sunlight-generated free iron that produce harmful radicals during exposure to bright sunlight in order to prevent the unwanted side reactions that can lead to sk...

'Conversation stoppers' fight deadly bacterial infections

...inhibiting enzymes such as Abh4, we may be able to disrupt the activity of a single class of endocannabinoids, rather than all of them." In the new study, the researchers provide biochemical evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are especially ...

Nanotechnology propels advances in regenerative medicine research

...inhibiting enzymes such as Abh4, we may be able to disrupt the activity of a single class of endocannabinoids, rather than all of them." In the new study, the researchers provide biochemical evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are especially ...

Brown seaweed contains promising fat fighter, weight reducer

...inhibiting enzymes such as Abh4, we may be able to disrupt the activity of a single class of endocannabinoids, rather than all of them." In the new study, the researchers provide biochemical evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are especially ...

Study shows enzyme builds neurotransmitters via newly discovered pathway

...inhibiting enzymes such as Abh4, we may be able to disrupt the activity of a single class of endocannabinoids, rather than all of them." In the new study, the researchers provide biochemical evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are especially ...

Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease

.... By targeting these amino acids, new drugs could disrupt the ability of these viruses to shut down immune systems and make them vulnerable to the body's natural defenses. "This brilliant study shows that many viruses, including HIV, use a similar mechanism to disarm their victims," said Gerald Weissman...

New mechanism underlying pain found

...ations of certain chemical structures that seem to disrupt this rhythmic transmission." Ion channels are openings that exist within a cell that allow the passage of certain ions into a cell to regulate activity. It is believed that hundreds of different types of ion channels exist in the body, each with a...

Plague proteome reveals proteins linked to infection

...guide drug and vaccine designers in their quest to disrupt the microbe’s ability to infect. Y. pestis is the bacterium that caused the infamous Black Death plagues. Fleas are vectors for the disease and can spread it to rodent and human hosts. This study mimicked environmental conditions of Y. pestis in ...

A wolf in sheep's clothing: Plague bacteria reveal one of their virulence tricks

...ng site not only impairs the bacteria's ability to disrupt the host cytoskeleton," Stebbins says, "but it decreases its virulence significantly." "It's rare to find something that has such a strong effect that you can hit one protein so specifically, knock out essentially half its activity, and have such a ...

Restoring tamoxifen sensitivity in resistant breast cancer cells

...unds are being studied because of their ability to disrupt cellular activity at the genetic level. These so-called electrophilic compounds were first investigated for possible use against AIDS because they can block the human immunodeficiency virus (HIV) from replicating. The HIV studies are ongoing. "This...

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