disease 2 5

Tag: "disease" at biology news

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

... allowing researchers to follow the development of disease in one subject and to monitor the effects of interventions on disease progression and outcome. Crucial information can be obtained noninvasively, repeatedly and quantitat...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...r no response at all. Given the variability of the disease and treatment response, being able to predict how a particular patient is likely to respond to interferon would help doctors decide how close to monitor the patient or even whether to consider alternative treatments. In a new study, Sergio Baranzini ...

Substance protects resilient staph bacteria

... against all pathogens in which PGA is a basis for disease development, such as Staph and anthrax." The group used genetic and biochemical analyses to show that PGA is produced in S. epidermidis. They then used three S. epidermidis strains--one natural, one altered to eliminate PGA production and one altere...

Epstein-Barr virus protein crucial to its role in blood cancers

... from these studies will be in lymphoproliferative disease in transplant and immunocompromised patients because this is a clear case of EBV-driven B-cell lymphoma. The use of peptides to block the interaction between this essential EBV protein and the specific pathway in human B cells is currently underway....

Defensins neutralize anthrax toxin

... from these studies will be in lymphoproliferative disease in transplant and immunocompromised patients because this is a clear case of EBV-driven B-cell lymphoma. The use of peptides to block the interaction between this essential EBV protein and the specific pathway in human B cells is currently underway....

Viral protein influences key cell-signaling pathway

...leukemia or lymphoma (ATLL). ATLL is an aggressive disease characterized by a long latent period and the proliferation of T lymphocytes. The virus is spread by sexual activity, by contact with infected blood and by infected women to children through breast milk. HTLV-1, like its cousin HIV, inserts its gene...

Molecular models advance the fight against malaria

...herapy, may hold the key to a new treatments for a disease that afflicts more than half a billion people worldwide. The scientists developed disease models using yeast and successfully introduced five mutations that make malaria resistant to the ant...

Discovery Promises Simpler Therapy for Sickle Cell Disease

... Academy of Sciences. The symptoms of sickle cell disease have generally been attributed to the physical obs... to red cell membranes might therefore prevent the disease symptoms, opening up a new realm of therapeutic possibilities, Stamler said. Current therapies fail ...

Iron exporter revealed that may explain common human disorder

...erloaded with iron. Left untreated, the hereditary disease can lead to organ failure. The new work, led by r...d intestinal absorption. Indeed, patients with the disease exhibit a deficiency of hepcidin, a hormone that binds ferroportin and targets it for destruction. ...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...s, and the first test to conclusively identify the disease in living patients. Chad Mirkin and William Klein... our hypothesis that there are many biomarkers for disease that go under the radar of conventional diagnostic tools. The extraordinary sensitivity of the bar c...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...people each day to protect against coronary artery disease and reduce the incidence of heart attacks--limit cholesterol synthesis by inhibiting reductase function, he said. As a result, cells take up more cholesterol from the bloodstream, lowering its concentration there. However, inhibition of reductase fu...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...n prions, the infectious proteins behind "mad cow" disease and Creutzfeld-Jakob disease in humans, suggests that the ability of prions in one species to infect other species depends on the...

WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas

...26 December, the organization is strengthening its disease surveillance, stagnant water conditions creating c...al authorities to implement effective vector-borne disease prevention and control activities", said Dr Samlee Plianbangchang, WHO Regional Director for South-E...

Gene Therapy Cures Inherited Liver Disease In Rats

...-virus combination cured rats of a inherited liver disease in which lack of a gene causes the accumulation of...Academy of Sciences. "This is the first time this disease (Crigler-Najjar syndrome) has been completely cured long term with a single injection in an adult an...

Researchers identify protein crucial for survival of Lyme-disease bacterium

When the tick-borne bacterium that causes Lyme disease lacks a specific protein that responds to an incom...ademy of Sciences. The bacterium that causes Lyme disease lives in infected mammals and in the midgut of ticks. When an infected tick bites an animal or a hum...

Light therapy may combat fungal infections, new evidence suggests

...fe as they lead to human disease, as well as plant disease and mold," said Idnurm, a post-doctoral fellow at Duke. "However, fungi also play important beneficial roles, for example, as a source of food and pharmaceuticals. "Therefore, an understanding of the role of environmental signals such as light in fu...

Computational Method Speeds Mapping of Cell Signaling Networks

...ion would be particularly useful for understanding disease states where signaling malfunction plays a prominent role, including cancer and autoimmunity. Until now, the large amounts of data the technique requires prevented its application to protein networks. Being able to monitor multiple components in tho...

Marburg haemorrhagic fever in Angola update

...rhagic fever difficult: the extreme rarity of this disease and its similarity to other diseases seen in count... poor road conditions. Fortunately, spread of the disease beyond Uige Province, located in the interior of the country, has been limited. Of the 266 cases and...

Alzheimer's cognitive decline slowed

...nd cognitive tests have suggested that Alzheimer's disease patients with genetically modified tissue inserted...present the first therapy for a human neurological disease that acts by preventing cell death." In this first-ever gene therapy for Alzheimer's disease, UCSD ...

Scientists identify molecule that regulates well-known tumor suppressor

...tics. Interestingly, DJ-1 may play a role in other disease states, as it has also been recently identified as a predictive diagnostic for early-onset, autosomal recessive Parkinson's disease. The other members of the research team include Raymond H. Kim, YingJu Jang, and Tak W. Mak of Ontario Cancer Institu...

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