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Tag: "disables" at biology news

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

...bacterial enzyme, called sphingomyelinase (SMase), disables a protein in lungs called CFTR, for cystic fibrosis transmembrane conductance regulator. SMase is made by the bacteria that cause pneumonia, some anthrax-causing bacteria, and bacteria that cause opportunistic infections in CF and AIDS patients. I...

RNAi shows promise in gene therapy, Stanford researcher says

...ch diseases as cancer or macular degeneration, or disables genes needed by an invading virus. With key genes shut off, viruses such as hepatitis or HIV are unable to multiply and cause disease. In early RNAi experiments, researchers saw some hints that the technique could induce an immune reaction or s...

Morphine makes lasting -- and surprising -- change in the brain

...archers pinpointed the very molecule that morphine disables ?guanylate cyclase. This enzyme, or inhibitory neurons themselves, would be effective targets for drugs that prevent or treat addiction....

Regulating the nuclear architecture of the cell

...that codes for the HP1 protein; or a mutation that disables RNA interference -- allows the heterochromatin to open up. The decondensed, repeated DNAs are then free to interact; DNA recombination and repair processes excise the DNA from the chromosome to form extrachromosomal DNA. If these extrachromosomal loo...

Scientists discover role for dueling RNAs

...RNA blocks the sense RNA. In other words, the gene disables its own ability to make protein. "This is the first case where a specific function in a higher cell for antisense RNA has been found," says Fink, senior author on the paper. "This points to an entirely new process of gene regulation that we've n...

UBC researchers find stroke death channel

...n cells during stroke, causing the cell death that disables stroke victims. The findings were published recently in Science and will be the subject of an editorial in next month's issue of Nature Reviews Neuroscience. "We've known for 40 years about chemicals flowing out of cells after stroke, but nobody k...

Drug dials down the energy within cells, UM researchers find

... initiation of a process that selectively kills or disables disease-causing cells." Glick and collaborators published their findings in the June 16 issue of ACS Chemical Biology. The drug, discovered by Glick and coworkers and called benzodiazepine-423 (Bz-423), is a chemical cousin of anti-anxiety medicati...

Bacteria give up secrets in war waged on plants

...t author on the paper. "The bacteria targets and disables a plant's defense protein, so they can get in and multiply," Nomura said. "It's a very nice strategy for bacteria, very clever." The P. syringae virulence protein, called HopM1, has been the mechanism mystery. Plant diseases, ranging from bacterial...

New male contraceptive clears hurdle

...produced (known as the vas deferens). The gel then disables the sperm as they swim by. In study animals, male fertility returns if the RISUG is flushed out with another injection that dissolves the gel. Elaine Lissner, director of the nonprofit Male Contraception Information Project in San Francisco, says sh...

Bacterial protein mimics host to cripple defenses

...vrPtoB, a protein Pseudomonas injects into plants, disables PCD in a variety of susceptible plants and in yeast (a single-celled ancestor of both plants and animals). Abramovitch and Martin compared AvrPtoB's amino acid sequence to known proteins in other microbes and in higher organisms, but found no matches...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

...a dangerous nerve condition called neuropathy that disables many people with diabetes, said a research team led by Baylor College of Medicine in Houston. The report from researchers at BCM, Shiga University of Medical Science in Japan, and the University of Chicago appears online today in the Proceedings of ...

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