Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
...history than any other infectious disease, uses to disable its host's immune system. "Yersinia pestis is the nastiest thing alive," said study author Olaf Schneewind, M.D., Ph.D., professor and chairman of microbiology at the University of Chicago and director of the Great Lakes Regional Center of Excellenc...Researchers reveal secret of key protein in brain and heart function
...ure is solved, scientists can create a molecule to disable it. That, in turn, will allow them to fully understand SAP97's role in the body. And that will point drug makers to targets for developing new ways to treat cardiac or neurological diseases. "To arrive at a solution, you need to understand the probl...Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits
...reenings of those molecules' ability to completely disable target proteins. Ideker said protein interaction information could help modify that approach to drug discovery. "Maybe the target protein has a good and necessary role in 10 interactions, but the 11th is the only one we would need to eliminate," said...New SARS Protein Linked To Important Cell Doorway
...much of the knowledge they need to develop ways to disable or weaken it. "The key to studying novel viruses used to be the ability to isolate the virus and grow it in a culture," notes lead author Daved Fremont, Ph.D., assistant professor of biochemistry and molecular biophysics and of pathology and immunol...New, automated tool successfully classifies and relates proteins in unprecedented way
...e like cancer, where you mightwant to identify and disable part of a tumor cell's machinery needed toprocess proteins for cancer growth."Our tool represents a step forward because it is based on standardizedfeatures and not on features chosen by the human eye, which isunreliable. By automating the clustering...