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Tag: "directly" at biology news

First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes

...ead the idea that the plagues of Europe were not a directly infectious disease but were outbreaks of bubonic plague, overturning an accepted belief that had stood for 550 years. Professor Duncan and Dr Scott illustrated in their book, Return of the Black Death (2004, Wiley), that this idea was incorrect and t...

Turning viruses into allies against cancer

... cell death. When the modified virus was injected directly into human liver cancer cells grafted onto laboratory mice, scientists observed significant prolongation of life; complete regression was achieved in up to one-third of the treated mice. During the second phase of their study, the scientists attache...

Protein helps regulate the genes of embryonic stem cells

...histone modification, and it's those proteins that directly have an impact on gene expression - either by acti...onic stem cells because they thought that would be directly applicable to stem cell technologies. "In order to get a handle on individual stem cell therapeutic...

At long last, scientists figure out how plants grow

...ists had not known at the time that TIR1 interacts directly with auxin (also known as indoleacetic acid, or IA...make sure that the binding of TIR1 to auxin is not directly influenced by other plant cell proteins. Auxins influence a wide variety of plant processes. For ex...

Genetic therapy reverses nervous system damage in animal model of inherited human disease

By injecting a therapeutic gene directly into the brain, researchers have treated a natural...lved in the study are born with a genetic disorder directly analogous to alpha-mannosidosis or AMD, an inherited disease in humans that causes severe mental ret...

Defensins Ward Off HIV In Two Ways

...itions where viral burden is low, alpha-defensin-1 directly inactivates HIV virus. When serum is present, alpha-defensin-1 acts on vulnerable cells to block HIV infection at the stage when the virus is taken up by the cell and begins replicating itself and integrating into the host. The authors also show that...

Elephant seal pups suffer from ocean warming

...ir mothers; changes in ocean temperature therefore directly affect the weight, and the survival rate, of the pups. To assess the impact of temperature changes on food availability to elephant seals, Le Boeuf and Crocker monitored the weight of 2750 elephant seal pups over a period of 29 years, from 1975 to 2...

UCLA scientists store materials in cells natural vaults

... Therapeutic delivery, such as homing cancer drugs directly to a tumor cell without harming healthy tissue * Enzyme delivery to replace missing or defective enzymes, such as those that cause Tay Sachs disease * DNA delivery to correct genetic mutations * Timed release of drugs, enzymes and DNA ...

Basis for DNA ejection from single phage particles

...a membrane so that the genome is delivered without directly contacting the membrane. Phage nucleic acid transport poses a fascinating biophysical problem: Transport is unidirectional and linear; it concerns a unique molecule the size of which may represent 50 times that of the bacterium. The driving force fo...

Oldest cranial, dental and postcranial fossils of early modern European humans confirmed

... attempts to radiocarbon date the Mladec specimens directly have failed, but in the present attempt by using t...elements, the Mladec assemblage becomes the oldest directly dated substantial assemblage of modern human remains in Europe. ...

Researchers develop assay that could be applied to drug screening

...single clathrin coated vesicles. We have now shown directly that coated pits can produce multiple vesicles in succession." Using a specially adapted microscope, Zenisek and his colleagues Christien Merrifield and David Perrais, simultaneously measured the minute movements made by coated pits as they invagina...

Tendency to hair loss inherited from the mother

...y defect can therefore sometimes also be passed on directly from father to son. Bald men wanted In order to identify more genes involved the research team is searching for more volunteers. "Men under 40 with severe hair loss can take part," Dr. Kruse says. "If they have a brother who is affected and the pare...

Conserved amino acids play both structural and mechanistic roles in sandwich-like protein

...rve to direct the process of protein folding. "We directly demonstrated that in one protein within the large ...otein folding is crucial for curing human diseases directly related to misfolding of proteins, and it is also important for the design and improvement of therap...

Stealth Worms May Improve Insect Pest Control

...nus, spiracles. Or the nematode may enter the host directly by using a dorsal tooth. Once inside the insect, the nematode vomits the pathogen, which kills the host within 24 to 48 hours and even digests its tissues, creating a perfect environment for the EPN to grow and multiply. One or more adult generation...

Future diabetes drugs may target new protein interaction

...rganism's lifespan. "We now know that sirtuin1 is directly involved in the response to calorie restriction in mammals and in processes involved in cellular aging," says Puigserver. "But we still don't know whether sirtuin1's activity affects lifespan in mammals." There is a precarious anecdotal link, howeve...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...rganism's lifespan. "We now know that sirtuin1 is directly involved in the response to calorie restriction in mammals and in processes involved in cellular aging," says Puigserver. "But we still don't know whether sirtuin1's activity affects lifespan in mammals." There is a precarious anecdotal link, howeve...

Computational verification of protein-protein interactions by orthologous co-expression

...rganism's lifespan. "We now know that sirtuin1 is directly involved in the response to calorie restriction in mammals and in processes involved in cellular aging," says Puigserver. "But we still don't know whether sirtuin1's activity affects lifespan in mammals." There is a precarious anecdotal link, howeve...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...rganism's lifespan. "We now know that sirtuin1 is directly involved in the response to calorie restriction in mammals and in processes involved in cellular aging," says Puigserver. "But we still don't know whether sirtuin1's activity affects lifespan in mammals." There is a precarious anecdotal link, howeve...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

...ies against external agents (helper T cells) or by directly attacking and destroying cells infected by foreign invaders (killer T cells). Gamma-delta T cells migrate from the thymus to epithelial tissues such as skin and the linings of the lung. While their precise role remains poorly understood, they perform...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

... release insulin where it will do the most good -- directly into a key blood vessel known as the portal vein," Hammerman explains. In a collaboration with scientists at the University of Alabama-Birmingham, Hammerman has received funding from the Juvenile Diabetes Research Foundation to transplant pig pancre...

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