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Tag: "directing" at biology news

Common molecular 'signature' identified in solid tumors

...e list of the most active ones provides a guide to directing future research. "We know that there are hundreds of miRNAs, and some of them may have multiple gene targets. Finding the ones that appear over and over again in various forms of cancer will help us design new and better interventions," says Croce....

How IVF could be causing genetic errors in embryos

...his stage. "These studies are important for better directing future resources and studies in humans. But we must remember that these are preliminary results in a mouse model, and they need to be repeated and confirmed in other strains of mice before translating to studies in humans." Other research has sugges...

Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection

... cells (Teff cells) are involved in activating and directing other immune cells, while regulatory T cells (Tregs) act to curb the over-aggressive responses of the T cell population. Researchers continue to work on devising ways to mobilize anti-tumor Teff cells in order to better shape the immune response to ...

Scientists reverse evolution

... as Hox genes, which are like orchestra conductors directing the actions of other genes during development of an animal embryo. Until sometime between 530 million and 480 million years ago, early animals had 13 Hox genes. Then, in jawed fish ?the last common ancestors of modern vertebrate animals ?each Hox ...

Bacterial 'switch gene' regulates how oceans emit sulfur into atmosphere

...ganism groups are the primary plankton involved in directing DMSP away from forming DMS, and thus making sulfur unavailable to atmospheric processes. Dramatic advances in understanding how these plankton work have developed in the past few years with the availability of new genomic data. The scientists searc...

Study of gene transfer for erectile dysfunction shows promise

...ny, in which Christ and Melman are co-founders and directing members. The therapy is known as ion channel therapy because the proteins it targets are potassium channels, "gates" within cells critical for contraction and relaxation of smooth muscle. At the Wake Forest Institute for Regenerative Medicine, Ch...

Minorities, uninsured less likely to receive care at high-volume hospitals

...health care policy experts in improving quality by directing patients to high-volume hospitals, policy development should include explicit efforts to identify the patient and system factors required to reduce current inequities in the receipt of care at such hospitals," the authors conclude. ...

How does a zebrafish grow a new tail?

...ation, much like the conductor of an orchestra. By directing cell communication, these few cells grow into an organ or body part, in this case, a tail fin. "It is most likely the inability of humans to form a blastema in the first place that renders us unable to re-grow arms and legs," said Cristi Stoick-Co...

U of MN researchers find novel genes critical in organ development

...side of cells in the body, and are responsible for directing "patterning" in the body, or ensuring that cells divide, differentiate and migrate to properly form vital organs in the correct places during development. The research is published online in the current issue of the Public Library of Science journ...

Researchers find docking sites for glucocorticoid receptor and Hsp90

...hat would control specific Hsp90 activity, such as directing the response of cells to glucocorticoids, said the study's principal investigator Beatrice D. Darimont, a professor of chemistry and researcher in the Institute of Molecular Biology at the University of Oregon. Glucocorticoids are naturally produc...

Key to lung cancer chemo resistance revealed

...t studies have shown that NRF2 detoxifies cells by directing proteins to absorb and pump out pollutants and chemicals. The NRF2 gene makes a "trigger" protein which starts the production of other proteins and enzymes that sweep the cell clear of toxins. To halt the detox process, proteins manufactured by KEA...

Nanoscale microscope sheds first light on gene repair

...X is distributed in the cell nucleus: in clusters, directing the first aid/repair after DNA injuries to the region where it is really needed. Many biological processes lie out of the visual reach of scientists. The benefits of high-resolution electron microscopy are often offset by disruptive sample prepara...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

... to becoming rods. After almost two decades of directing fundamental research on retinal development and degenerative diseases, Swaroop believes that scientists are at last entering a period of rapid discovery. "This provides a clear example of how basic fundamental research can contribute to treatment of ...

Scientists use nanoparticle to discover disease-causing proteins

...ally or abnormally. Proteins also are important in directing immune responses. The Purdue scientists report on their new strategy to discover proteins and protein levels, called soluble polymer-based isotopic labeling (SoPIL), in the current issue of the journal Chemical Communications. The study also is fe...

Researchers learn what sparks plant growth

...rmis and followed into the inner layers of tissue, directing those cells to grow or to restrict growth. The outer epidermis, which helps plants retain water and regulate the exchange of gases, clearly plays the role of environmental sentinel, communicating to plant tissues when conditions are right to seize...

Gene thought to assist chemo may help cancer thrive

... “P53 has long been recognized as a key player in directing chemotherapy-damaged cancer cells to self annihilate, but less attention has been paid to p53’s role in repairing damaged cells,”said John McDonald, chair of Georgia Tech’s School of Biology and chief research scientist at the Ovarian Cancer Institut...

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