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Tag: "directing" at biology news

Hirsute Or Hairless? Two Proteins May Spell The Difference

...ll “crosstalk?that controls bud formation by first directing a small cluster of epithelial cells to form a placode, the pouch that forms hair plugs. The placode in turn directs underlying mesenchymal cells to form the base of the hair follicle, called the dermal papilla, and both structures contribute to the m...

New insight into regulation of blood stem cells

...esearch will be useful for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts. Blood cell formation, known as hematopoiesis, begins with a hematopoietic stem cell (HSC), which can either "self-renew" and make more copies of itself or differentiate into e...

Newly discovered pathway might help in design of cancer drugs

...rs to target treatment more precisely, rather than directing chemotherapeutic medication or radiation to tumors through a scattershot approach, said Marc Greenberg, a chemistry professor in the university's Zanvyl Krieger School of Arts and Sciences, who will present his team's findings on March 14 at the 229t...

New lead reported in tumor angiogenesis

...ly data also suggest the intriguing possibility of directing growth-inhibiting drugs at the normal blood vessel cells to stop angiogenesis. "It's well established that tumor cells can become resistant to chemotherapy," said Dr. Wang. "For endothelial cells, which are the cells that line the walls of the blood ...

Mechanism regulating tooth shape formulation found

...oto now propose a 'balance of induction' mechanism directing the placement of tooth shape features called cusps. Position and shape of cusps determine whether a tooth shape belongs to human or mouse, for example. Whereas developmental initiation of cusp formation is known to involve several developmental genes...

Huntington's cure in flies lays groundwork for broader treatment approaches

... more may be involved. Though many might argue for directing research dollars to the continued search for epilepsy genes, Yin believes funding agencies should now consider investing in the search for these "superhighways" of gene convergence. That search might be long and tedious, he adds, but it's most certa...

Single gene is genetic switch for fly sexual behavior

...h the male version of fruitless behave like males, directing at other females a sexual display nearly identical to their male counterparts. Female flies with the male version of the protein also make amorous advances toward male flies that express female pheromones. In these cases, "we have been able to rever...

UCLA discovery will aid in treatment of patients with a deadly brain cancer

...ng the molecular signature of patients' tumors and directing those with the right protein combination to EGFR blocking therapies. Mischel's team also is working to uncover the molecular signatures in the tumors of non-responders so they can determine what therapies might be most effective for them. "This is a...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...have the potential to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, therapeutic nanoparticles (~50 ?~250 nanometer) are specially designed delivery vehicles that can encapsulate a drug within them and release t...

Researchers use 'trickery' to create immune response against melanoma

...have the potential to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, therapeutic nanoparticles (~50 ?~250 nanometer) are specially designed delivery vehicles that can encapsulate a drug within them and release t...

Common molecular 'signature' identified in solid tumors

...e list of the most active ones provides a guide to directing future research. "We know that there are hundreds of miRNAs, and some of them may have multiple gene targets. Finding the ones that appear over and over again in various forms of cancer will help us design new and better interventions," says Croce....

Researchers unlock how cells determine their functions

...a, Riverside have discovered a molecular mechanism directing the fate and function of cells during animal development. The findings could hold promise for the advancement of cancer and stem-cell research. The research is published in the Feb. 24 edition of the journal Science. UCR Biochemistry Professor Fran...

Powerful new tool for studying brain development

...xpression of hundreds of genes that play key roles directing brain development, controlling the expression of other genes, guiding protein production and transporting molecules within the cell. A key part of the BGEM's success was the development at St. Jude of bioinformatics software that routinely searches...

Light activated anticancer drug targeted to DNA using cisplatin like sub-units

...target the drug to DNA using cisplatin like units, directing the light activation to tumor cells and the sub-cellular target, DNA. "In the past, our light activated systems had to find the DNA within the cell, an often inefficient process. Now we have added the DNA targeting drug," Brewer said. "We were work...

Environmental metagenomics diagnosing extreme environments, tapping opportunities for clean energy

...ment of Energy Joint Genome Institute (DOE JGI) is directing the technology of DNA sequencing to scan the environment for processes that will lead to cheaper and easier to produce biofuels. "Through DNA sequencing and the tools of molecular biology we can generate diagnostic fingerprints, Environmental Gen...

When mice choose mates, experience counts

...egration of inadvertent social information used in directing mate choice of female mice," says Pfaff. "Of course, we don't know if it works the same way in humans. But many have speculated that social influences do play a role in how we choose our friends and partners." ...

Animals can change genes quickly to keep up with viral ingenuity

...viruses by homing in on viral genetic material and directing its enzymatic destruction. Viruses can evolve quickly to out-maneuver RNAi mechanisms, but hosts would be expected to rapidly evolve countermeasures of their own to resist new viral strategies. The new research provides evidence for such rapid evolut...

A new focus for the mechanism of nerve growth

...ling the actin networks and ultimately sensing and directing nerve growth. Proteins in the Myosin family function as molecular motors; the most familiar myosins power contraction in heart and skeletal muscles. Myosin II motors are involved in functions such as directed cell movement, cell division and wound c...

New insights into neural tube defects

...stribution restores polarity in the daughter cell, directing them to migrate to the midline of the neural tube. ...

Efficiency, not more doctors, is the prescription for aging population

... increasing the efficiency of medical practice and directing resources to care that has been proven to be effective. They point to large interdisciplinary (or multispecialty) group practices, a structure that has been in place in many parts of the United States since early in the 20th century, as models of bo...

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