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Genomic Analysis Uncovers New Targets for HIV Vaccine

...d early online by the journal Science July 19, was directed by David Goldstein,Ph.D., at Duke University and is the first large cooperative study with major findings arising from the Center for HIV/AIDS Vaccine Immunology, (CHAVI) a seven-year project funded by the National Institute of Allergy and Infectious...

Caribbean frogs started with a single, ancient voyage on a raft from South America

...volutionary biologist and professor of biology who directed the research. "Because land connections among continents have allowed land-dwelling animals to disperse freely over millions of years, the fauna of any one continent is usually a composite of many types of animals." Yellow and black spotted frog ...

Researchers demonstrate way to control tree height

...ich plants such as rice or wheat were created that directed less energy to height growth and more to development of stout stems and plentiful seed. In orchards, semi-dwarf fruit trees produce more fruit that is easier to harvest. The improvements in cereal yields have been credited with preventing the starvat...

3-D ultrasound scanner provides in-depth view of the brain

... member Srinivasan Mukundan of Duke Medical Center directed a needle into a particular region of the animal's brain, as is required in surgeries to drain cerebrospinal fluid and relieve pressure on the brain. In a second animal, the researchers made use of dyes to enhance ultrasound images of blood vessels in...

Surprising origin of cell's internal highways

...und that microtubules originating at the Golgi are directed toward the cell "front," or the leading edge, of motile cells. Since such an orientation is needed for directional migration, Kaverina hypothesizes that this subset of microtubules may influence cell motility by facilitating the transport of proteins...

Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin

...y to large numbers and tweak them so that they are directed to create a needed organ. In this way, he said, physicians might avoid the usual pitfall involved in transplanting cells or organs from other people — organ rejection, which requires organ recipients to take immune-suppressing drugs for the rest of t...

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

...ascular lesion is of autoimmune origin: antibodies directed against particular proteins of the virus are able ... This new study therefore confirms that antibodies directed against Cytomegalovirus-derived proteins purified from patients with coronary artery disease induce ...

HIV survival improves if patients stay in care

...e on line. "In an era when highly active therapy directed against HIV (the human immunodeficiency virus that causes AIDS) is keeping people alive, understanding the value of regular medical care is crucial," said Dr. Thomas Giordano, assistant professor of medicine ?infectious diseases at BCM and lead autho...

100 percent of pregnant women have at least one kind of pesticide in their placenta

... research group to which María José López belongs, directed by Prof. Nicolás Olea Serrano, has conducted several studies which associate exposure to pesticides with neonatal malformations if the genito-urinary system, such as cryptorchidism (undropped testicles) and hypospadias (total fusion of the urethral f...

Super-fermenting fungus genome sequenced

...rade product. Now, the power of genomics is being directed to optimize this age-old process. “The information embedded in the genome sequence of Pichia has helped us identify several gene targets to improve xylose metabolism,?said Pichia paper lead author Thomas W. Jeffries of the Forest Products Laborato...

Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies

... immune system. In this therapy the antibodies are directed to the immune system cells in order to provoke a stronger reaction against cancer. This has the advantage of exploiting a mechanism with an action distinct from the other strategies currently being used to treat cancer, and is capable of interacting ...

Need oxygen? Cells know how to spend and save

...oin with oxygen to form water. This final step is directed by the protein cytochrome coxidase, or COX for short. If electrons react with oxygen before reaching COX, they generate "free radicals" that can damage or destroy cells. The mitochondria are designed to produce energy without excess free radical prod...

UCSD researchers discover variants of natural tumor suppressor

...nt level of glucose in the bloodstream. Therapies directed at inhibiting PHLPP1 could be used to treat diabet..., the path involved with cell survival. Therapies directed at releasing the brake on this driver would allow cells involved in heart or neurological diseases t...

Antibody therapy prevents type 1 diabetes in mice

...ctions and other foreign substances in the body -- directed against a receptor known as CD137 on the surface of a type of immune cell called T-cells. Treating NOD mice with the anti-CD137 antibodies significantly suppressed the development of diabetes, whereas most of the control mice developed diabetes by th...

Elucidation of the genome for diabetics with DNA chips

...h-British-Canadian collaboration between the teams directed by Philippe Froguel (CNRS, University of Lille 2, ...DESIR study, a prospective study run by INSERM and directed by Beverly Balkau. The key results of this first screening were then confirmed in more than 5500 Fre...

OHSU lab finds meth receptor that could lead to therapy

...nd behavioral effects," explained Grandy, who also directed the groundbreaking research. "In our most recent article, we provide clear evidence that methamphetamine is a full and potent agonist of TAAR1. In other words, TAAR1 has the necessary features to be considered a real target of methamphetamine and...

40,000-year-old skull shows both modern human and Neandertal traits

...e recovered during a systematic excavation project directed by Professor Trinkaus and Professor Zilhao between 2003 and 2005. Radiocarbon dating of the specimen produced only a minimum age (more than 35,000 years), but similarity in morphological traits with the Oase 1 human mandible ?found in 2002 on the s...

Knocking out survival protein could aid leukemia treatment

...ate that Mcl1 may be an effective target for drugs directed against CLL and ALL," says principal investigator John C. Byrd, professor of internal medicine and director of the hematologic malignancies program at Ohio State's James Cancer Hospital and Solove Research Institute. "These results give us a rati...

Resistance to anti-HIV drugs in Uganda developed due to drug supply problems

...nts did a great job of taking their medications as directed when they were affordable and available, their overall adherence did wane a bit over the study period," said Oyugi. ...

New evidence of 'human' culture among primates

...imes. The act was apparently an aggressive one, directed at Dr Moura as a potential predator, but as the group became used to his presence in the area the stone-banging decreased. Furthermore, in a large minority of cases, adults and juvenile monkeys were seen banging the stones together without paying him...

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