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Tag: "dimmer" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...genes on and off and adjust their activity, like a dimmer switch that varies the brightness of a light. Co-activators join with other regulatory proteins called transcription factors in controlling the expression of genes. Spiegelman and Jiandie Lin, PhD, the paper's lead author and a researcher at Dana-Far...

Overbearing colored light may reveal a second mechanism by which birds interpret magnetic signals

...birds' orientation significantly, in comparison to dimmer light levels. The researchers found that in dim turquoise light, similar to that found about 33 minutes after sunset, the birds show normal migratory orientation, with the seasonal shift between southerly directions in autumn and northerly directions...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

... translating genes into proteins. They work like a dimmer switch, reducing the amount of available gene product, in this case the enzyme BACE1. A modified lentivirus, which has been developed in Verma's lab, delivered the siRNAs into the brain cells of the transgenic mice that were producing vast amounts o...

A 'dimmer switch' for genes

...ng genes on and off, but in a way that resembles a dimmer switch rather than an on-off switch. Genes carry ...acting like an on-off switch, it behaved the way a dimmer switch does to regulate lighting in a gradual manner." In studying how this fine-tuning worked, the...

Switching genes to overdrive improves muscular dystrophy symptoms in mice

...a switch, or perhaps more accurately, like a light dimmer that increases or decreases the activity of genes under its control. Exercising a muscle raises PGC-1alpha levels, causing the formation of more mitochondria, the chemical power plants that create energy in cells. PGC-1alpha is also required for t...

Mutating the entire genome

...n or off, or turn their activity up or down like a dimmer switch. Other DNA sequences are responsible for folding and packing DNA into the nucleus of each cell. Five percent to 50 percent of DNA is considered useless junk, “depending on who you ask, although probably at least half of the ‘junk’ DNA is g...

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