Tag: "differentiation" at biology news

Priming embryonic stem cells to fulfill their promise

...ed cell typesfound in the body.Embryonic stem cell differentiation is complex and far from fullyunderstood. Scientist...ernal inputsknown to be involved in triggering the differentiation of stem cells:soluble growth factors, adjacent cells, mechanical forces, andextracellular matrix pro...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

..., many of the specializedmedia used for growth and differentiation still contain materials fromanimal sources and are hence contaminated with Neu5Gc.In addition to using human serum, the researchers suggested thepossibility of using what are called "feeder cells" from mice with ahuman-like defect in Neu5Gc productio...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecul... of the molecular programs that regulate stem-cell differentiation is necessary for harnessing this potential. ### This work was supported by grants from the Nationa...

Scientists discover the cellular roots of graying hair

...ators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?depletion. MITF, they conclude, seemsto play a crucial role in maintaining the supply of stem cells withinthe hair follicle, and graying is the result of “incomplete maintenanceof melanocyte ste...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...ators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?depletion. MITF, they conclude, seemsto play a crucial role in maintaining the supply of stem cells withinthe hair follicle, and graying is the result of “incomplete maintenanceof melanocyte ste...

Scientists rid stem cell culture of key animal cells

...onic stem cells to differentiate appear to inhibit differentiation in mouse embryonic stem cells. Aside from feeder cells, two other sources of animal material remain in stem cell culture materials. One, Matrigel, is a product that is essentially a plate-coating matrix of cells extracted from mouse tumors. Serum re...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...ators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?depletion. MITF, they conclude, seemsto play a crucial role in maintaining the supply of stem cells withinthe hair follicle, and graying is the result of “incomplete maintenanceof melanocyte ste...

UCSD researchers maintain stem cells without contaminated animal feeder layers

...viously been shown to modulate cellular growth and differentiation in human pancreatic cells. Human embryonic stem cells cultured for several weeks under these conditions showed no change in cell form and structure. The team then eliminated each factor and pluripotency was assessed. At first, the results were narrow...

UCSD team discovers specialized, rare heart stem cells in newborns

...UCSD) School of Medicine. The cells are capable of differentiation into fully mature heart tissue. Called isl1+ cells, these cardiac progenitor cells are stem cells that have been programmed to form heart muscle during fetal growth. Until this new discovery, the cells were thought to be absent after birth. However,...

New insight into regulation of blood stem cells

...ul for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts. B...latelets. The genes that control proliferation and differentiation have been difficult to study using traditional gene disruption methods because loss of genes thought...

New tumor-suppressor gene discovered

...revealed that the mats gene is required for normal differentiation of eye cells during the development of the fly's eye. Lai's team also tackled the tough challenge of discovering how the mats gene is able to suppress the growth of tumors. "We did not find many clues when we compared the sequence of the mats gene w...

Scientists generate patient-specific stem cells, Science study says

...ers must develop methods to efficiently direct the differentiation of embryonic stem cells to specific stable cell types. Scientists must also find a way to remove the remaining animal components from the laboratory procedures. Currently, the procedure for isolating non-reproductive cells for the nuclear transfer me...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

...ers must develop methods to efficiently direct the differentiation of embryonic stem cells to specific stable cell types. Scientists must also find a way to remove the remaining animal components from the laboratory procedures. Currently, the procedure for isolating non-reproductive cells for the nuclear transfer me...

Human Eggs Can Develop From Ovarian Surface Cells In Vitro

...sa cells. The authors speculate that this bipotent differentiation may represent a sophisticated mechanism created during the evolution of female reproduction, and not seen in ovaries of female prosimians (ancestral primates) or mice carrying germline stem cells. The ability to produce mature human eggs from adult ...

Biologists determine genetic blueprint of social amoeba

...for studying cell polarity, how cells move and the differentiation of tissues. It also exhibits many of the properties of white blood cells. Three years ago, another team of UCSD biologists discovered that two genes that are used by Dictyostelium to guide the organism to food sources are also used to guide human wh...

Brain size may depend upon how neural cells are cleaved

...peutic use, the role of G protein signaling in the differentiation of such progenitor cells is going to be a very exciting area to explore," she said. ...

AACR Favors 'full spectrum of stem cell research biology'

...will elucidate critical aspects of cell growth and differentiation that are altered during the formation and growth of tumors. # Research on tissue-specific stem cells from adults may reveal the body's innate maintenance and repair mechanisms. # Embryonic stem cells have the ability to transform into the cells of ...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...ntial late phase contributions to organ repair via differentiation of stem cells into cells that have been destroyed in ARF," the study noted. ...

Fish and chips: A fast track to understanding blood development

...rstood is which genes control the self-renewal and differentiation processes, and how these genes could be used to influence, or regulate, these processes. The research will be published in the July issue of the journal of Public Library of Science Biology. "If we can find a way to coax blood stem cells to self-re...

The making of a fat cell

...oliferation of mesenchymal stem cells, followed by differentiation into fat cell precursors called preadipocytes. Mesenchymal stem cells can differentiate into various cell types, including bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where...

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