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Tag: "differentiated" at biology news

Priming embryonic stem cells to fulfill their promise

...ould formthe optimal "niche" for a desired type of differentiated cell.In their experiments, the UCSD researchers took advantage of theknowledge that the extracellular matrix in liver is comprised primarilyof just five proteins. They applied spots of all 32 possiblecombinations of the five proteins as engineered ni...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...ontrollably, rather than from the vast majority of differentiated cells that make up organs where cancers are found. If this theory is correct, resident stem cells in the skin could be the cells that turn into skin cancers like melanoma. Understanding stem cell biology may therefore be important for developing new ...

Nanogen Issued Patent for Electronic Microarray With Memory

...perty portfolio illustrates our ability to develop differentiated advanced diagnostic products that add value to the company and to research and clinical laboratory customers," said Howard C. Birndorf, Nanogen chairman of the board and CEO. This new patent expands Nanogen's intellectual property portfolio to inclu...

UCSD team discovers specialized, rare heart stem cells in newborns

...ay of function that one would expect in completely differentiated heart tissue," said the study's co-first author Jason Lam, Ph.D. candidate in the IMM. The cells exhibited contractility, pumping ability, the correct electrical physiology and normal heart structure. In addition, the progenitor cells coupled with ne...

Leprosy microbes lead scientists to immune discovery

...large white blood cells known as monocytes rapidly differentiated into the two distinct cell types, forming the body's emergency response to the detection of foreign bacteria. One category of defensive cells, macrophages, seek out and engulf the infectious bugs. The other group consists of dendritic, or "antigen-pr...

Gene keeps neural cells on correct developmental path

...he first to track a set of genes from stem cell to differentiated neuron. It also reveals fundamental details of how...ndel said. "We can't detect REST in the terminally differentiated neuron." But some molecular partners of REST remain, perhaps fine-tuning gene expression in mature n...

Breakthrough isolating embryo-quality stem cells from blood

...em cells. Stem cells are cells which have not yet differentiated into specialised tissues such as skin, brain or muscle. They promise a new class of regenerative medicine, which could repair apparently permanent damage such as heart disease or Parkinson's. The cells are currently taken from aborted human foetuses,...

Scientists generate patient-specific stem cells, Science study says

...ording to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for immune-system tolerance, therapeutic efficacy and safety. Initial laboratory experiments showed immune system compatibility between the stem cell lines and the cells of people who supplied each lin...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

...ording to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for immune-system tolerance, therapeutic efficacy and safety. Initial laboratory experiments showed immune system compatibility between the stem cell lines and the cells of people who supplied each lin...

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

...node, they don't have an orientation. Nor are they differentiated into specialized tissues -- such as heart or brain cells," he said. Once through the doorway, embryonic stem cells have their marching orders: they "know" where to locate themselves in the developing organism and what to differentiate into. "Paradox...

Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments

...uries." While all neurons are originally born and differentiated from their stem cell progenitors during development, the adult brain maintains at least some regions where neural stem cells create new neurons to replace old and dying ones. One area is the subventricular zone of the lateral ventricles, which are fl...

Combination therapy leads to partial recovery from spinal cord injury in rats

Combining partially differentiated stem cells with gene therapy can promote the growth of new "insulation" around nerve fibers in the damaged spinal cords of rats, a new study shows. The treatment, which mimics the activity of two nerve growth factors, also improves the animals' motor...

Researchers grow stem cells from human skin

...nto becoming fat, muscle and bone cells. When the differentiated cells were seeded onto three-dimensional molds and implanted in mice, they maintained features consistent with bone, muscle and fat tissue. "Our study shows that stem cells can be obtained from a simple skin biopsy and can be made to become three vit...

AACR Favors 'full spectrum of stem cell research biology'

...these cells will be used only as precursors to the differentiated cells needed to replenish damaged tissue. In light of the recent cloning of patient-specific human embryonic stem cells by researchers in South Korea, AACR Science Policy and Legislative Affairs Committee Chairman William G. Nelson V, M.D., Ph.D., p...

Optimizing cell therapy against tumors is a balancing ACT

...s are more effective for tumor treatment than more differentiated T cells. In an accompanying commentary, Daniel Speiser and Pedro Romero write, "optimal therapeutic efficacy may depend on different T cell selection and preparation strategies" and these findings indicate that a pragmatic strategy for ACT is to kee...

Tissue regeneration operates differently than expected

... integrated into the tissue complex by fusing with differentiated tissue cells. In contrast, in the heart muscle tis...ere based on the fusion of stem cells with already differentiated muscle cells. Although, like the researchers from Bad Nauheim show, cultivated mesenchymal stem cel...

Master regulatory gene found that guides fate of blood-producing stem cells

...t in diseases like leukemia, the first scenario-no differentiated cells, two HCSs developing-must occur because more... like bone-marrow failure, the second scenario-two differentiated cells and no HCSs-happens because the body runs out of HSCs. "We want to figure out how this proces...

Regenerating worms help elucidate stem cell biology

...ing. "The animal will survive on the virtue of its differentiated cells," Sánchez Alvarado said, "but as the tissues... daughter cells that are competent to restore aged differentiated cells during homeostasis as well as missing tissues after amputation. Unlike what's been thought abo...

Model identifies genes that induce normal skin cells to become abnormal

... The Hendrix lab has hypothesized that this poorly differentiated cell type serves as an advantage to aggressive cancer cells by enhancing their ability to metastasize virtually undetected by the immune system. The group's current study tested the hypothesis that the microenvironment of metastatic melanoma cells c...

USC researchers track down the stem cells that create feathers

...ting them into a chicken host. (Quail cells can be differentiated from chicken cells by cellular markers.) This demonstrated that only the labeled cells were pluripotent. These stem cells, the researchers found, are well protected in the follicular base of each individual feather follicle. As they proliferate and ...

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