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Tag: "differentiate" at biology news

Wisconsin scientists grow critical nerve cells

..." says Zhang. "Otherwise, it just won't work." To differentiate into a functional spinal motor neuron, the stem ce...onstrates that human stem cells do not necessarily differentiate in linear fashion, as scientists always believed. Rather, a series of complex overlapping changes ma...

Spleen may be source of versatile stem cells

...t thatcommitment, the splenic cells may be able to differentiate into a widervariety of cells than can adult stem cells from bone marrow, which donot produce Hox11.The researchers also note that the spleen develops from embryonictissue that is known not only to generate precursors to many types ofblood cells, a fu...

Neuronal 'traffic jam' marks early Alzheimer's disease

...s pathology by using human embryonic stem cells to differentiate into neurons in culture. Their goal is to alter those neurons genetically by introducing mutations know to cause Alzheimer's disease in people, to then test for transport defects, and then study whether those defects produce pathology similar to that...

Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates

...ly demonstrated that mouse embryonic stemcells can differentiate into neurons when cultured under specificconditions. These same culture conditions, technically simple andefficient, were recently applied to primate embryonic stem cells andresulted in the generation of large numbers of DA neurons. In theircurrent J...

U-M scientist to talk about tissue engineering at AAAS

... new bone. Bone morphogenetic proteins help cells differentiate into specific kinds of bone, and encouraging cells to make more BMPs during tissue engineering also can ramp up the effects. "Together these therapies can overcome compromised environments," he said. "Combining therapies can help us overcome some of...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...Without it, cells do not stop dividing and fail to differentiate into the normal structures of the worm ?instead they make an excess of their cells. After identifying let-7 as a cell division regulator, Slack's team used bioinformatics and found the relationship to Ras. Let-7 in humans is identical to the sequenc...

New Clues Add 40,000 Years to Age of Human Species

...llected hundreds of new mammal fossils that helped differentiate layers of sediment and link the currently dry region to its moister climates of the past. But, precisely dating the outcrops required volcanic minerals with elements that undergo radioactive decay. Brown and McDougall collected rocks containing vol...

Scientists rid stem cell culture of key animal cells

...cules that encourage human embryonic stem cells to differentiate appear to inhibit differentiation in mouse embryon...lls because, in their absence, stem cells start to differentiate within two to three days. Xu started by evaluating the effect of changing stem cell growth condition...

U-M scientists find genes that control growth of common skin cancer

... that regressing BCC cellscould be reprogrammed to differentiate into various epithelial celltypes, ultimately capable of assembling fully-formed hair follicles.These results suggest that BCCs contain cells capable of multi-lineagedifferentiation, similar to normal hair follicle stem cells from whichthey may arise...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...ells, and how these optical signals change as they differentiate into nerve, muscle, and other tissues. "At present, there's no rapid method for identifying the transitional states [of a stem cell] with the functional cell type it eventually becomes. That process is a mysterious sequence of metabolic and genetic c...

Programmable cells: Engineer turns bacteria into living computers

...bryos, for example, the first cells are thought to differentiate into the head, abdomen and other parts based on the concentration of chemical signals that are emitted from the ends of the embryo. In addition to conducting laboratory experiments, Weiss and colleagues are creating computer models of their engineer...

Researchers devise way to mass-produce embryonic stem cells

...Researchers aren't sure why or how some stem cells differentiate without prompting. Yang and Ouyang tested both se... ways to program embryonic stem cells so that they differentiate into specific types of cells. In preliminary work, Ouyang has created a network of neurons from undi...

Single stem cells from bone heal a broken heart

...an cells at the single cell level and were able to differentiate them into all different cell types. When single human bone marrow–derived stem cells were allowed to divide to form a large population, they were transplanted into a rat model of myocardial infarction. This improved cardiac function because the cells...

Heart repair gets new muscle

...art damage, they migrate to the damaged tissue and differentiate into cardiac muscle cells. Epstein and colleagues...ult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro. PLoS Biol 3(4): e87. ...

New insight into regulation of blood stem cells

...her "self-renew" and make more copies of itself or differentiate into either red blood cells, various types of white blood cells, or platelets. The genes that control proliferation and differentiation have been difficult to study using traditional gene disruption methods because loss of genes thought to be critica...

Leprosy microbes lead scientists to immune discovery

...to raise the alarm. The TLRs spur the monocytes to differentiate into the two rapid response cell types. Why this matters became strikingly clear when the scientists studied different forms of leprosy for the presence of the two cell types. (One of the types, the microbe-eating macrophages, is labeled DC-SIGN+, w...

Double triumph in stem cell quest

...ESC markers. His team has also shown the cells can differentiate into a number of cell types, including heart muscle cells, neurons and blood stem cells, although the results have not yet been published. Trounson, whose team has been experimenting with a similar approach, says far more detailed studies will be ne...

Of mice and men's (and women's) contraceptives

...at need to be used at specific times as germ cells differentiate into mature sperm and eggs," explains Hecht. "An equally likely possibility is that the absence of MSY2 disrupts the timing of how specific mRNAs are used during germ cell differentiation. As cells become mature sperm, there's a precise order of synt...

Gene keeps neural cells on correct developmental path

...rrangement that stays intact as non-neuronal cells differentiate into liver, muscle, and other tissues. The new study reports that REST uses a different temporary off mechanism to direct neuronal development. "This study shows that there is more than one way to keep a REST-regulated gene repressed," said Michael ...

Scientists generate patient-specific stem cells, Science study says

...cells in the body. For example, the stem cells can differentiate into cells that display characteristics of skin and retina cells, muscle cell bundles, bone matrix cells and cells of the gastrointestinal and respiratory lining. One of the next preclinical steps, according to the authors, is to evaluate, in the la...

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