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Tag: "diabetic" at biology news

Teasing out tissue from blood

.... "We now want to transplant these cultures into a diabetic mouse model," says Winnier, adding their results are being prepared for publication in a peer-reviewed journal. Alan Colman of ES International, a company developing insulin-producing cells from human ESCs in Singapore, is also sceptical. He says it...

MIT 'seeing machine' offers hope to blind

...d a wide range of cause for vision loss, including diabetic retinopathy, macular degeneration (the fastest growing cause of blindness), and visual field loss," said Cavallerano, a coauthor of the paper and another of Goldring's doctors. Participants used the machine to view 10 examples of Goldring's visual ...

Microscopic scaffolding offers a 'simple' solution to treating skin injuries

...ide a safer, more effective way of treating burns, diabetic ulcers and similar injuries. This ultra-fine, 3-dimensional scaffold, which is made from specially developed polymers, looks similar to tissue paper but has fibres 100 times finer. Before it is placed over a wound, the patient's skin cells (obtaine...

Epidemic of unneeded amputations

...er extremity amputees is less than 50 percent. For diabetic amputees, the rate is less than 40 percent.--In a five-year study in medical journal Diabetes Care, 40 percent of diabetics and 29.8 percent of non-diabetics had a second amputation to the same or opposite limb at an average of 16.2 and 12.3 months, ...

Trial success for diabetic nerve therapy

...hat the research could lead to a new treatment for diabetic nerve damage or 'neuropathy'; initial-stage clinic...o prevent or slow the progress of nerve disease in diabetic patients," he said. "Our tests have shown that a single injection of a DNA-binding protein protecte...

Proteins spur diabetic mice models to grow blood vessels, nerves

...hey also restored blood vessel and nerve growth in diabetic mice. Dean Y. Li, M.D., Ph.D., a cardiologist and ...oted blood vessel growth equally well. But in the diabetic mice, netrins proved markedly better at promoting blood vessel and nerve growth than VEGF, according...

Wisconsin scientists find a way to make human collagen in the lab

...e sensors that might, for example, quickly alert a diabetic to falling insulin levels. Similarly, equipped with molecules to recognize specific pathogens, such a sensor could stand perpetual guard in the body and provide instant warning of invading viruses or bacteria. "We can have total control of what goes...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

...he Yerkes Research Center for transplantation into diabetic rhesus macaques using an anti-rejection protocol d...ered a major advantage over adult pig islets. The diabetic animals were treated with a CD28/CD154 co-stimulation blockade-based immunosuppressive regimen, and ...

Scientists directly view immune cells interacting to avert autoimmunity

... was able to focus deep within the lymph node of a diabetic mouse, allowing the researchers to show that immune cells known as T regulatory, or Treg, cells control the destructive action of rogue autoimmune cells when each of the two cell types interact with a third kind of cell. The role of the third cell t...

Scientists pinpoint inflammation gene

...ns. ChemGenex researchers found that the obese and diabetic sand rats exhibited a different pattern of a previously undiscovered gene, which is now known to be SEPS1. Given the results in animals, the SFBR-led team was brought in to determine whether this gene is relevant to inflammation in humans. ...

New cell transplantation technique restores insulin production in diabetics

...ance to inject donor cells into the portal vein of diabetic patients, which is accessed through the skin," sai...ive technique, donor islet cells are injected into diabetic patients so that the new, healthy islet cells can restore insulin production, essentially stopping t...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

...mmation of pancreatic islets in recently diagnosed diabetic mice. As T lymphocytes invade the pancreas, blood vessels swell, become more permeable, and leak fluid ?as well as small molecules carried in the fluid ?into surrounding tissues. In previous experiments, the researchers demonstrated that this leakage...

Molecular miners find pain relief drugs from the sea

...s to test the effectiveness of ACV1 in humans with diabetic neuropathies will soon be underway and we expect t...1 needed for the planned human clinical trials for diabetic neuropathy. "With an increasing age demographic in our society the need for more effective pain sup...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

...ation with Chan, performed numerous experiments in diabetic rats and mice. Their work defined the role of the ...is possibility. Discovering an underlying cause of diabetic neuropathy may enable us to design treatment strategies to prevent this complication in the future,"...

Diabetic nerve therapy shows 'striking' results

...used by diabetes could bring relief to millions of diabetic patients, say experts. The treatment might also r... study has massive potential for the management of diabetic neuropathies or nerve disorders. "Diabetic neuropathy is a major problem in insulin-dependent diabe...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...as critical to their earlier successes in treating diabetic rats with embryonic pig tissues. In those experim...t they didn't have to give anti-rejection drugs to diabetic rats treated with embryonic pig cell transplants. They had expected rats that received no immune sup...

Genetic defects give the immune system the green light to attack the pancreas

...A chips and “genome scans.?They compared non-obese diabetic (NOD) mice, which researchers elsewhere had shown to have the tolerance defect, with diabetes-resistant controls. They looked for regions where the data from the DNA chips and the genome scan converged. Overlap would indicate the regions and genes th...

Stem cells from brain transformed to produce insulin at Stanford

...to insulin-producing cells. When transplanted into diabetic mice, these cells effectively made up for the lost insulin-producing cells in the pancreas, called islet cells, and treated the diabetes. However, embryonic stem cells are difficult to work with in the lab and most existing human embryonic stem cell ...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...sulin-producing cells into the woman's 27-year-old diabetic daughter. The transplanted islets began producing...nts who need it, Shapiro added. The mother of the diabetic daughter was in perfect health, while her daughter has been on the cadaver donors transplant list si...

Towards precise classification of cancers based on robust gene functional expression profiles

...hat they showed in previous studies is elevated in diabetic animals and may be involved in the cascade of immunological events that leads to the destruction of the pancreas and the subsequent onset of type 1 diabetes. The disease is much less common than type 2 diabetes, formerly known as adult onset or non-i...

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