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Tag: "diabetes" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ic research on fat cells and metabolic pathways in diabetes and cancer at Dana-Farber. "It offers the opportunity to try to understand what makes these fatty acids so deleterious, and what we need to avoid." Moreover, it is possible that in the future, drug therapy might be used to "turn down" the mechanism,...

Spleen may be source of versatile stem cells

...o address theautoimmune reaction underlying type 1 diabetes actually cured thedisease in diabetic mice. Late in 2003 they reported the mechanismbehind the earlier discovery: cells from the spleens of donor mice -intended to train the diabetic animals' immune systems not to attackislet cells - were actually pr...

W.M. Keck Foundation funds study of friendly microbes

...n to obesity and obesity-related disorders such as diabetes and heart disease. Unfortunately, comprehensive analysis of the composition and functions of these microbial communities, in health and in disease, has been hampered because the majority of gut bacteria are difficult or impossible to grow and study ...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

... weight have a high potential of developing type 2 diabetes later in life. In studies of mice, the researchers...500 mg/dl -- the equivalent of serious, full-blown diabetes in humans," Dr. Patti said. In type 1 diabetes, the pancreas cannot make the hormone insulin at all...

Sea skate experiment sheds light on human cell transport

...ings could explain the problem. People with type 1 diabetes don't produce insulin. Without that hormone, vesicles aren't inserted into cell membranes ?and glucose can't be moved between cells. And when channels are blocked, damaged cells can't die. This cell "suicide" is one of the body's defenses against ca...

Highly adaptable genome in gut bacterium key to intestinal health

...n to obesity and obesity-related disorders such as diabetes and heart disease The bacterium of the study, called Bacteriodes thetaiotaomicron or B. theta, is among the most abundant species in the human gut microbial community. B. theta breaks down otherwise indigestible carbohydrates, such as dietary fiber,...

Development of portable infectious disease detector

...nage their disease in a way that is similar to how diabetes patientscan monitor their condition since the introduction of home bloodglucose detectors." The collaboration's goal is to produce its firstportable HIV monitor within two years. In addition to such "point ofcare" devices, Wikswo and Pyle are joining...

NJIT Presidential Award winner takes stem cell research another step

...pport the team's research. "People suffering from diabetes have impaired bone healing," Arinzeh said. "So the question is how to treat patients suffering from bone fractures and other defects that may not heal because they are also suffering from other disorders. We are looking at the current treatment for r...

Boosting HIV screening can increase survival and is cost effective

...tions, including breast cancer, colorectal cancer, diabetes and hypertension. Paltiel said that even in settings with HIV infection levels similar to the U.S. general population, one-time screening could deliver excellent return on investment. "HIV is a severe disease that, left untreated, produces substanti...

FDA Approves New Drug to Treat Type I and Type II Diabetes

...ll be the only therapy for the treatment of type 1 diabetes other than insulin. Patients with type 2 diabetes already have several other types of oral therapies available. The safety and efficacy of Symlin wer...

PCRM develops world's first cruelty-free insulin assay

... had two options available to us when we began our diabetes trials," said Dr. Barnard. "One, we could use test kits with insulin antibodies grown in vivo--literally from cells injected into the abdomens of live mice--or we could use kits containing antibodies produced from cells cultured with fetal calf serum...

Opposing fat metabolism pathways triggered by a single gene

... for treatment of fat metabolism disorders such as diabetes and obesity. ### Citation: Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto K (2005) Nuclear hormone receptor nhr-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3(2): e53. ...

Chemists identify key gene in development of type 1 diabetes

...ked the gene for the MIF protein failed to develop diabetes compared to mice that possessed the gene, accordin...the researchers reported they were able to prevent diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. If human stu...

International HapMap consortium expands mapping effort

...elated to common diseases, such as asthma, cancer, diabetes and heart disease. When the project was launched ...an another. For any given disease, such as type II diabetes or coronary artery disease, researchers can use the HapMap to compare the genetic variation patterns...

Vascular structure and function improve with diet and exercise

...ure and two-thirds to three-fourths of people with diabetes mellitus die of some form of heart or blood vessel disease, according to the American Heart Association. "For both of these groups, their lifetime risk of developing hypertension is high," Petrella said. "Anything we can do to reduce that is importa...

Towards precise classification of cancers based on robust gene functional expression profiles

...ked the gene for the MIF protein failed to develop diabetes compared to mice that possessed the gene, accordin...the researchers reported they were able to prevent diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. If human stu...

Surprising findings reported about iron overload

...oad and HFE mutations in the development of type 2 diabetes in persons of various racial/ethnic groups. ...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...uld allow many more desperate patients with type 1 diabetes to get successful islet transplants," says Dr. Shapiro. "The donor operation is relatively safe, but is not entirely devoid of serious potential risk," he added. A shortage of donor islet cells is the biggest obstacle preventing implementation for a...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...oxygen delivery to tissues, such as heart failure, diabetes and pulmonary hypertension. Collaborators on the study include lead author John Pawloski and Douglas Hess. The work was supported by the National Institutes of Health and a Doris Duke Clinical Scientist Development Award. ...

Stem cells from brain transformed to produce insulin at Stanford

...ls in people with diabetes. Right now, people with diabetes face a lifetime of insulin injections. In rare cases, some patients can receive cell transplants from cadavers, but that source of cells is far smaller than the total number of people who could benefit. ...

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