Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
...ound that these worms require let-7 RNA for normal development to occur. Without it, cells do not stop dividing and fail to differentiate into the normal structures of the worm ?instead they make an excess of their cells. After identifying let-7 as a cell division regulator, Slack's team used bioinformatics and...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...xplain how exposure to BCE affectshuman nerve cell development and how it might relate to neurologicaldisorders. ...ering neural development,and alterations in neural development are thought to be a cause ofautism," says Jill Kreiling, first author of the paper and a member ofRe...Mouse brain tumors mimic those in human genetic disorder
...children with NF1.Second, the time course of tumor development was similar to that seenin humans. Unlike most tum... cells in the brain. Butit was unclear whether the development of blood vessels and recruitmentof microglia helped trigger tumor formation or if they appeared only...Automatic extraction of gene/protein biological functions from biomedical text
...he rapid advancement of biomedical science and the development of high-throughput analysis methods, the extraction of various types of information from biomedical text has become critical. Since automatic functional annotations of genes are quite useful for interpreting large amounts of high-throughput data effi...Enzyme allows B cells to resist death, leading to leukemia
...is. Theauthors suggest that Lyn is involved in the development of B-CLL andthat this enzyme therefore represents an attractive target for therapy.The study will appear online on January 13 in advance of publication inthe February 1 print edition of the Journal of Clinical Investigation....Scientists rid stem cell culture of key animal cells
...and a co-author of the Nature Methods paper. "This development is a good step in that direction. Also, clinically, the feeder cells were one of the main sources of potential contamination with pathogens, so their elimination should improve safety. However, not all the animal components have been removed from the...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...nown specifics of how genes get switched on during development of the human body and in diseases such as cancer. "Each type of cell in our bodies contains the same genes. What makes them do different things involves which genes are turned on," notes Bradley Bernstein, a pathologist at Harvard Medical School. He...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
...which transcription factor (TF) genes regulate the development of thatbrain region, and which of them to investig... is freely accessible to researchers studyingbrain development and disorders.To compile the atlas, the investigators first sifted through databasesof information f...New research questions basic tenet of neuron function
...ontaneous release is thought to play a role in the development of the neural circuitry in the brain and body, while activity-dependent release is responsible for functions such as learning and memory. ...Critical role in programmed cell death identified
...nues for studying and targeting a process vital to development and implicated in cancer and autoimmune diseases. ...essential for life; it's needed for nervous system development and it keeps the body up and running. Miscues and failures are instrumental in cancer, autoimmune di...Genetically modified natural killer immune cells attack, kill leukemia cells
...icant technical hurdles that have until now slowed development of NK-based therapies for ALL, according to Dario ...y breakthroughs made by the St. Jude team were the development of a laboratory technique for rapidly producing a large, pure population of NK cells from a small sa...Open microfluidic and nanofluidic systems
... relation between basic research and technological development in the micro- and nanoregime: open systems with di...he methods of theoretical physics. In general, the development of any new technology requires a systematic understanding of the underlying physics. This latter con...Researchers discover molecule that causes secondary stroke
...ins given off by the brain bleed contribute to the development of specific molecules that later causes the constricting vasospasm." A research team led by Dr. Clark has now identified the molecules that trigger vasospasm, a breakthrough, he says, that "raises hopes of developing not only new ways to treat the co...Researchers trace evolution to relatively simple genetic changes
...plasin pathway, an important part of the embryonic development process. The human disorder, one of the earliest o... molecule is expressed in ectodermal tissue during development and instructs certain cells to form teeth, hair and sweat glands. It also seems to control the shape...Scientists reveal molecular secrets of the malaria parasite
...three stagesin their vertebrate hosts and a sexual development stage during whichthe parasite is transmitted between vector and host.The Science paper represents the culmination of four years ofcooperative work by scientists at several research institutes,including: the Wellcome Trust Sanger Institute in the U.K...Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
...plasin pathway, an important part of the embryonic development process. The human disorder, one of the earliest o... molecule is expressed in ectodermal tissue during development and instructs certain cells to form teeth, hair and sweat glands. It also seems to control the shape...Studies reveal methods viruses use to sidestep immune system
...thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and W... and control host immune defenses will aid in drug development to combat disease, he said. In the Virology paper, Dr. Gale and his research group found that a spe...Development of portable infectious disease detector
...d medicaldiagnostics, agreed to collaborate on the development before theholidays.VIIBRE has spent the last three years developing the ability to measurethe metabolism of small groups of cells and studying how they respondto drugs, toxins and pollutants. To do so, the interdisciplinary teamhas developed two basi...Alcohol's effects on gene expression in the central nervous system
...ng effects, sensitivity to the effects of alcohol, development of tolerance to the effects of alcohol, development of alcohol dependence, and alcohol withdrawal severity," he said. "For the average reader, knowing w......ated with internal bleeding, liver failure and the development ofprimary liver cancer. There is a huge imperative to develop newapproaches to the treatment of liver scarring. Exciting insights suchas these will inform the design of future therapies."Further research into macrophages is set to follow and scientis...