Hirsute Or Hairless? Two Proteins May Spell The Difference
...s question—specifically, how structures and organs develop from buds. In a new study, Elaine Fuchs and colleagues use a three-pronged approach—involving gene expression analysis, transgenic mice, and cell cultures—to study how epithelial buds, the precursors of hair follicles, form. Their experiments point t...UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
... research. "Embryonic stem cells have the power to develop into every type of human tissue," said Witte, who ...at could be used to test new therapeutics that may develop as a result of the stem cell studies, said Judith C. Gasson, cancer center director, stem cell insti...Researchers devise way to mass-produce embryonic stem cells
...f cell in the body, while adult stem cells usually develop into a type of cell based on the kind of tissue that they originated from. The bioreactor has a chamber that holds the polymer threads on which the stem cells grow and another chamber that holds fluid, or medium. This medium delivers chemical messen...Epstein-Barr virus protein crucial to its role in blood cancers
...omponent of the cell cycle for control. Now we can develop targeted therapeutics to disrupt the function of this viral protein." The researchers surmise that the first use of future therapies from these studies will be in lymphoproliferative disease in transplant and immunocompromised patients because this i...Defensins neutralize anthrax toxin
...omponent of the cell cycle for control. Now we can develop targeted therapeutics to disrupt the function of this viral protein." The researchers surmise that the first use of future therapies from these studies will be in lymphoproliferative disease in transplant and immunocompromised patients because this i...HIV vaccine trial breaks ground for future research
...ycoprotein, similar to the type of vaccine used to develop a vaccine for hepatitis B. The vaccine was tested in a double-blind, randomized study of healthy participants who did not use intravenous drugs. The volunteers were men who have sex with men or women at high risk for heterosexual transmission. The va...Molecular models advance the fight against malaria
... unlikely. "Within the next 3-5 years, we hope to develop a new drug that will finally empower us to treat this terrible disease," said Trumpower. Dartmouth Medical School co-authors of the paper are Dr. Jacques Kessl, research associate in biochemistry, Kevin Ha, Anne Merritt and Benjamin Lange. Other co-...Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
... the cells are “pluripotent,?meaning that they can develop into any of the 210 different cell types in the hu...blem, Dr. Lough looked at the way cardiac myocytes develop in the embryo itself. In research conducted on chick embryos since 1992, his team discovered that a ...New winter hulless barley has high protein
...iculture problems. Another of the projects aims to develop wheat and barley cultivars resistant to pests and so require fewer chemical inputs. For example, producers would obtain higher yields of a safer and higher quality grain that is resistant to Fusarium head blight, commonly referred to as scab. Scab pr...New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
... drugs in various situations and also will seek to develop better ways of determining how frequently and at what dose a drug should be given to minimize the development of resistance. They recently collaborated, for example, with NASA to analyze blood and tissue concentrations of an antibiotic in people livi...Multi-purpose protein regulates new protein synthesis and immune cell development
... that XBP1 helps immune cells called B lymphocytes develop into antibody-generating plasma cells. Plasma cell...er hematopoietic stem cells ?precursor cells which develop into many different types of blood and immune cells ?than normal mice. Zhang transplanted hematopoi...Glow-in-the-dark zebrafish at UH hold keys to biological clocks
... type of research can help with tracing why humans develop such things as sleep disorders or mental illnesses like depression." Per3 is the naturally occurring clock-regulated gene. The protein that it encodes is produced at highest levels near dawn, and when the luc gene is inserted into it, the luciferase...New insight into regulation of blood stem cells
...b controls HSC numbers and use this information to develop compounds that can regulate stem cell proliferation and differentiation. The ability to influence stem cell fate decisions would be expected to have a major impact on the field of stem cell therapy and to provide important in vitro model systems for ...UCSD-Salk Team Show Protein’s Gene-Silencing Role In Development of Nervous System
...off in the nervous system, neuronal stem cells can develop into specialized neurons. The researchers determined that SCPs are a component of a previously identified master gene complex called REST/NRSF, which is known to control neuronal genes. In their investigations with mice and fruit flies, the scientis...Promising new West Nile therapy cures disease in mice
...spread, medical investigators hastened research to develop an effective vaccine or therapy. None currently ex...e mice against death." The researchers decided to develop the potential treatment--known as a monoclonal antibody--after finding that antibodies taken from th...New drug shows promise as powerful anticancer agent
...ion, a reasonable approach to cancer therapy is to develop inhibitors that block the function of a critical molecule that is required by a tumor cell to complete cell division," explains lead author Dr. E. Premkumar Reddy from Temple University School of Medicine. "One such molecule appears to be Plk1." Dr....Chemicals in tattoo inks need closer scrutiny
...of tattoos among young people, it is vital that we develop a better understanding of this form of self expression." The new research ?a joint effort between Finley-Jones and Leslie Wagner as part of an undergraduate research project directed by Jani Ingram, a professor of chemistry at NAU ?has two main goal...Harmful chemicals may reprogram gene response to estrogen
...th a genetic predisposition for a disease actually develop the disease. The new research shows that when rat... to determine which individuals are more likely to develop cancers of the uterus, breast and prostate." The finding should alert doctors to ask more questions...Super predators and mass extinctions
...t controls mutation rates, allowing new species to develop over time. The model shows that, much of time, the system is populated with "medium efficiency" predators whose numbers fluctuate only slightly as the prey population waxes and wanes. Inevitably, their stable community is disrupted when mutations lea......lar toolbox" to provide the genetic information to develop plants to clean up polluted sites. Technologies developed at the center will be commercialized through a partnership with the Midwest Hazardous Substance Research Center, a U.S. Environmental Protection Agency regional hazardous substance research ce...