New comparative toxicogenomics database
... different types of polarizedlight by molecules to determine their shape. It also can show how thatshape can change when the protein interacts with another molecule.“This work required that we develop new NMR methods in order todetermine the shape of this protein, which undergoes changes as itinteracts with pI...UCSD researchers maintain stem cells without contaminated animal feeder layers
...oduct), and the UCSD team is continuing studies to determine if contamination occurs from this source. For a proposed animal-free medium, the UCSD study takes advantage of a previously unidentified soluble factor this is secreted from mouse feeder layers to maintain stem cells' undifferentiated state and plur...Researchers discover molecule that causes secondary stroke
...treat the condition, but also a diagnostic test to determine which hemorrhagic stroke survivors are at greater risk." Several spinal fluid components were suspected of causing the vasospasm, Dr. Clark explains. They included hemoglobin, bilirubin and peroxidized lipids, and a group of bilirubin oxidation prod...Study shows nanoshells ideal as chemical nanosensors
...teracts in such a way that it allows scientists to determine theirdetailed chemical makeup. This property, know...s, drug designers, chemists and otherscientists to determine what materials are made of. An enormouslimitation in the use of Raman scattering has been its extrem...Amino acids in nectar enhance butterfly fecundity: A long awaited link
...ral selection on nectar composition. In order to determine whether butterflies actually need nectar amino acids, researchers from the University of Basel raised map butterfly caterpillars on both nitrogen poor and nitrogen rich stinging nettle. After the butterflies emerged, they were fed nectar with or with...Development of portable infectious disease detector
...evelop"high-throughput" screening systems that can determine the biologicalactivity of large numbers of compounds with extreme rapidity and socould have a major impact on the drug discovery process.Fifteen years ago a number of start-up companies were created to makethe goal of creating a "lab-on-a-chip" a rea...Alcohol's effects on gene expression in the central nervous system
... "We were able to use gene expression profiling to determine that alcohol produces multiple effects on differen...g alcohol addiction. "Future research will need to determine changes in gene expression in very discrete neuronal pathways that may be involved in mediating the ...New SARS Protein Linked To Important Cell Doorway
...he protein, researchers purified it and used it to determine the three-dimensional structure of orf7a. This purified protein also allowed colleague Michael Diamond, M.D., Ph.D., assistant professor of molecular microbiology, to generate orf7a-specific antibodies. Andrew Pekosz, Ph.D., assistant professor of m...Nano-Probes Allow an Inside Look at Cell Nuclei
...ting drugs that target these processes. "We could determine whether a drug has arrived where it is supposed to, and if it is having the desired impact," says Chen. The first enduring look into the secret lives of cell nuclei comes by way of a strong collaboration between biologists and chemists. For the past...The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
...able researchers to quickly, cheaply, and reliably determine the shapes of many proteins found in nature. “One...teins simultaneously, cutting the time it takes to determine a single protein structure from months to days. For example, a robotic arm drops protein solution in...New insight into people who 'see' colors in letters and numbers
...umbers or letters, the researchers first sought to determine whether synesthetes really see the colors. In one such experiment, they presented six synesthetes with patterns of black letters or numbers--known as "graphemes"--on a white background. They chose those graphemes that the synesthetes reported elicit...New research indicates a 'troubled' greenhouse is brewing
...nfall, but Retallack says they also can be used to determine the seasonality of rainfall as well as the amount of rainfall because the spread within the profile of carbonate nodules is related to the difference in precipitation between the driest and wettest month. Retallack uses this feature in ancient soils ...Plants defy Mendel's inheritance laws, may prompt textbook changes
...t help identify and locate genes in organisms - to determine whether a plant carried normal or mutant copies of the genes. "It seems that these hothead-containing plants keep a cryptic copy of everything that was in the previous generation, even though it doesn't show up in the DNA, it's not in the chromosome...Scientists identify new model Of NK cell development
...erparts, the CD56 dim cells. "Our next goal is to determine if there is some developmental continuum at work here, supporting the notion that CD56 bright cells are really just immature CD56 cells," he adds. "This study raises almost as many questions as it answers," says Caligiuri, "Finding these nursery sit...Study of genomic DNA leads to new advances in cancer diagnostics
...ng invasiveness. Further study will be required to determine the specificity and sensitivity of these methods before they are used in the clinical setting. Physicians and researchers alike know that how a cancer cell interacts with its microenvironment is important for cancer progression. Such interactions mu...X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power
...Doug Swank of Rensselaer Polytechnic Institute, to determine what parts of the flight muscle proteins are responsible for the high speed. Collaborators on the X-ray project, in addition to Dickinson and Maughan, are Gerrie Farman, Tanya Bekyarova and David Gore of IIT, and Mark Frye of Caltech. ...UF Researchers Map Bacterial Proteins That Cause Tooth Loss
...to expose P. gingivalis to other oral pathogens to determine what interactions may exist that contribute to infection, he said. “This study is important in that we now have an understanding of the protein expression on a global scale for this pathogen,?Lamont said. “Now we need to see how it adapts to various...New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
...ves an injected test dose of radioactive Bexxar to determine how that patient's body processes the tagged antibody. Nuclear medicine scans are used to assess how quickly Bexxar reaches the tumor and how quickly the radiation disappears from the patient's body. One to two weeks after that initial dose, the pati...Scientists find fossil proof of Egypt's ancient climate
... and minor element analyses of the snail shells to determine information about the climate then," Kieniewicz said. "The shell is an archive of the snail's life. The analyses give us snapshots of what the conditions were like in that lake basin." The geochemical analyses confirmed that the water was a stable s...Ophthalmologists Use Artificial Silicon Retina Microchip To Treat Vision Loss
... trials, Pollack cautions it is still too early to determine what percentage of patients might experience improvement in vision and what resolution capability these patients might eventually have. "Although we hope that all patients receiving the chip will experience some improvement in visual function, we can...