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Tag: "deterioration" at biology news

Loss of stem cells correlates with premature aging in animal study

... “Think of aging as a slow loss of stem cells, a deterioration of pools of cells that reside in each tissue type,” says Brown. We accelerated the aging process by wiping out a large fraction of these cells prematurely, in one fell swoop. Essentially, these mice start their young adulthood with two strikes agains...

Keeping the immune system from starting a 'food fight'

...of insulin action, resulting in systemic metabolic deterioration over the long term," he continued....

First clinical trial of gene therapy for childhood blindness

...inal degeneration. This disease causes progressive deterioration in vision, due to an abnormality in a particular gene called RPE65. This defect prevents normal function of the retina, the light-sensitive layer of cells at the back of the eye. This results in severely impaired vision from a very young age and ther...

Intelligent materials to regenerate bone tissue

... also participating. In the case of substantial deterioration of the bone, it may be necessary for the implant to provide both functional and physiological properties of the damaged item. Given this hypothesis, the bone implants have to comply with a series of requisites capable of contributing to a reconstruct...

Gene tests and brain imaging reveal early dementia

...manifest themselves. Dementia involves a serious deterioration of mental function caused by some kind of dementia... people were the ones who went on to suffer memory deterioration two to three years later. "It's surprisingly difficult to diagnose Alzheimer's with any certaint...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...ordinating body movement and results in inexorable deterioration of the brain and spinal cord. Children suffering with Sandhoff rarely see their sixth birthday. Sandhoff mice are similarly affected. Tay-Sachs is predominant to Ashkenazi Jewish populations, while Sandhoff, a severe form of Tay-Sachs, is not limited...

Vasectomy may put men at risk for type of dementia

... The most common form of dementia caused by brain deterioration in individuals over age 65 is Alzheimer's disease. Weintraub did not find an increased rate of vasectomy in patients with Alzheimer's. Many patients with FTD and PPA share a common brain disease that is completely different from Alzheimer's. Whet...

NIH announces phase III clinical trial of creatine for Parkinson's disease

...no proven treatments that can slow the progressive deterioration in function. Creatine is marketed as a nutritional supplement. Studies have suggested that it can improve the function of mitochondria, which produce energy inside cells. It also may act as an antioxidant that prevents damage from compounds that...

Technology exists to keep E. coli out of food

...it produces a pH-neutral solution that won't cause deterioration or off-flavors when sprayed on food. The system is environmentally friendly; its only outputs are water and salt. Feirtag sees great potential for the system and is working to get it into the food industry (a few Minnesota companies are already usi...

Leading reason for corneal transplants comes into focus

...d States. In one form or another, FCD's trademark deterioration of the cells covering the clear, outermost lens of the eye affects more than 4 percent of the population over 40. Late in life, the dystrophy causes swelling of the cornea and can severely affect vision, making it impossible to see well even with gla...

Research suggests beta agonists may alter the immune system

...eta-agonist therapy. Although the reasons for this deterioration of asthma control are not clear, the Food and Drug Administration now recommends that the treatment of asthma with long-acting beta-agonists be supplemented with inhaled anti-inflammatory medications. Using blood samples from human participants, th...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

Muscle weakness and fiber deterioration seen in muscular dystrophy can be countered by a c...iseases, characterized by progressive weakness and deterioration of skeletal muscles. All are inherited, caused by a mutation in one of a group of genes responsible ...

Insulin receptor stops progression of Alzheimer's disease

...a agonist." Researchers were not able to stop the deterioration of insulin and its receptors. However, by administering PPAR, they were able to bypass the defects in insulin signaling and preserve the cells that need insulin to thrive. PPAR molecules go directly to the nucleus of cells and tell DNA to turn on or ...

Better sludge through metagenomics

...to protect lakes and rivers from eutrophication, a deterioration of water quality characterized by excessive algae blooms. Accumulibacter play a vital role in wastewater management, accumulating massive amounts of phosphorus inside their cells. "Engineers and microbiologists have been trying for 35 years to gro...

Free radical cell death switch identified

...time of oxidative stress leads to general cellular deterioration associated with aging and degenerative diseases. How the oxidative-stress signals trigger these profound effects in cells has remained unclear. But Bonni and his research team, including Maria Lehtinen, a graduate student in the HMS program in neur...

Scientists identify protein with a crucial role in cell death

Ageing, and the processes of deterioration that go with it, are largely attributable to cells... cell death is very important in the fight against deterioration diseases like dementia. In this light, researchers from the Flanders Interuniversity Institute for ...

Matrilin-3 gene discovered to prevent onset of osteoarthritis

... osteoarthritis, a joint disease that is caused by deterioration of cartilage, and usually occurs later in life. "Clearly there is a correlation between matrilin-3 and osteoarthritis. Potentially, we could use it as a diagnostic tool or to predict whether someone is likely to develop osteoarthritis," says senior...

Dying of excitement

...ing stroke and Alzheimer's disease. Indeed, brain deterioration after stroke is associated with elevated levels of glutamate -- the major excitatory neurotransmitter in the mammalian central nervous system (CNS) -- in the plasma and cerebral spinal fluid. One possible explanation for this glutamate build-up, rep...

New study shows benefit of early therapy in HIV-infected infants

...l recovery. They found that the risk of subsequent deterioration was similar for children initiating treatment in all age groups. Still, because initiating effective antiretroviral therapy before 5 months of age was strongly associated with more rapid improvement in CD4 cell count, the authors conclude it should ...

Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal

...mplications in delaying and slowing down cognitive deterioration in old age. The basis for these developments is Schwartz's team's observations, published today in the February issue of Nature Neuroscience, that immune cells contribute to maintaining the brain's ability to maintain cognitive ability and cell renew...

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