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Tag: "details" at biology news

Computational verification of protein-protein interactions by orthologous co-expression

...tuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American ...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...tuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American ...

Disabling gene defuses rheumatoid arthritis in mice

... Peng's group is currently trying to discern more details of Foxo3a's activities in neutrophils, including the pathways the gene activates to block apoptosis. They will also be looking for drugs that inhibit Foxo3a and testing them in the mice as potential anti-arthritis drugs. ### Jonsson H, Allen P, Pen...

Lipids get new comprehensive classification system

...and chemical representation system for lipids. The details of the system appear in the May issue of the Journal of Lipid Research, an American Society for Biochemistry and Molecular Biology journal. The new system is part of an effort by the Lipid Metabolites and Pathways Strategy (LIPID MAPS) consortium to...

Scientists discover odd-ball rodent

... yet, but there's a recent wiki article with more details . New family of mammals? Wow! Is it a squirrel? A rat? A Guinea pig? Try none of the above. A team of scientists working in Southeast Asia have discovered a long-whiskered rodent with stubby legs and a tail covered in dense hair. But don't call it...

U of T researchers map role of Epstein-Barr virus in cancer

...he University of Toronto have mapped the molecular details that show how a viral protein coded in the Epstein-Barr virus immortalizes cells and causes them to continuously grow, thereby predisposing people to certain types of cancer. "Epstein-Barr virus (EBV) is one of the most common human viruses in the w...

Critical step traced in anthrax infection

...ists at Harvard Medical School (HMS) have revealed details of a key step in the entry of anthrax toxin into human cells. The work, which grew out of an ongoing effort to produce a better anthrax therapeutic, shows that the protective antigen component of the bacterial toxin plays an active role in transferri...

Bacterial genome sheds light on synthesizing cancer-fighting compounds

...on about the metabolic capabilities of Prochloron, details that proved to be difficult to determine by other means, " said Patrick Dennis, manager for Prochloron genome sequencing at the National Science Foundation, which funded the study. "Furthermore, " he added, "by producing patellamides in the lab, the ...

ORNL, UC Berkeley unravel real-world clues to Earth's mysteries

...ges that, although this study provides interesting details of microbial community structure and function, a great deal of work remains to more fully explore the spatial and temporal aspects of how such a community grows, ages and adapts to its environment. ...

Scripps research scientists solve structure of a critical innate immune system protein

...eucine-rich repeats (LRRs). The structure reveals details of TLR3 that have never been seen before, an essential step toward fully understanding the critical role this protein--and other TLRs--play in the human innate immune system to rapidly detect invading pathogens. "We don't know functionally how TLR p...

Biologists determine genetic blueprint of social amoeba

...r understanding of human diseases. The scientific details of this seven-year-long genetic sequencing effort, which involved 97 scientists from 22 institutions in five countries, are contained in a paper featured on the cover of the May 5 issue of the journal Nature. The international team's achievement wil...

How monarch butterflies are wired for navigation

...em keep to a straight and true path southward. But details of their navigational machinery have remained a mystery. Now, researchers, led by Steven Reppert of University of Massachusetts Medical School, Ivo Sauman of the Czech Academy of Sciences and Adriana Briscoe of the University of California at Irvine...

Scientists track stealth DNA elements in primate evolution

...partment of Biological Sciences have unraveled the details of a 25-million-year-old evolutionary process in the human genome. Specific DNA sequences that appear to have persisted in a latent state for long periods of time may not be simply lying dormant. Instead, the researchers say that these elements have ...

Spiders help scientists discover how muscles relax

...ding how the thick filaments are activated." The details of their model permitted the researchers to explain how, in relaxed muscle, the heads of each myosin molecule are inhibited from interacting with actin by interacting with each other instead. When muscle is activated, they suggest, the bonds between ...

Biased reporting found in cancer prognostic studies

...es, instead including only a sample. Both of these details may have helped to fabricate the strong prognostic factor/cancer association in these studies, according to the authors. "These biases may create a spurious knowledge base of cancer predictors that may be of no use and may be potentially harmful," c...

Tagging pathogens with synthetic DNA 'barcodes'

...g for biological terrorism, they suggest. Further details on "tree-shaped" DNA appear in a paper in Nature Materials (Vol. 3, Pg. 38-42, 2004). ...

The synapse is a shotgun

... computer model by incorporating the physiological details of neurotransmitter release sites and receptors. The researchers then compared the behavior of the model under different scenarios with the electrophysiological behavior of actual ganglia measured in Berg's laboratory. The results, said Sejnowski, p...

Nanowires can detect molecular signs of cancer, scientists find

...e arrays have the potential to immediately fill in details on exactly what type of cancer is present. Nanowires could also track patients' health as treatment progresses. Because the arrays detect molecules suspended in fluids, drops of blood could be tested directly, in a physician's office, without any nee...

Envisat and ERS-2 reveal hidden side of Hurricane Rita

...ed to observe the storm during daylight, returning details of its cloud structure and pressure. Notably large waves are seen around the eye of Hurricane Rita in the radar image. ASAR measures the backscatter, which is a measure of the roughness of the ocean surface. On a basic level, bright areas of the ra...

UIC developing drug for SARS

...secar, associate professor of pharmacy, will study details of the three-dimensional structure of the two enzymes using x-ray crystallography. His technique involves bombarding a crystalline form of the enzymes with an intense beam of x-rays generated by a multimillion-dollar instrument at the Advanced Photo...

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