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Tag: "destroy" at biology news

Study IDs protein that inhibits HIV from growing in cell cultures

...the receptor, HIV can enter the cell, multiply and destroy the T-cell, thereby causing immune deficiency. "People with GBV-C have a slower rate of destruction of these T-cells," said Stapleton, who also is director of the Division of Infectious Diseases at the Iowa City VA and UI. The current study sh...

Plants give up answers in the war on bacteria

...tter understanding of how bacteria set up camp and destroy the plant's ability to fight infection. The work was funded by the National Institutes of Health and the U.S. Department of Energy and supported by the Michigan Agricultural Experiment Station. "We've known for 100 years that bacterial pathogens ...

HIV gets a makeover

...'t survive, but HIV-1 uses a protein called Vif to destroy APOBEC and prevent the attack. Monkey APOBEC proteins, however, aren't susceptible to the human virus's Vif. So Hatziioannou did another swap -- the SIV Vif gene for the HIV one -- and then another round of forced adaptation to create viruses that wo...

'Trojan Horse' agent halts bone metastasis in mice

...rchers have shown that the protein can selectively destroy blood vessels feeding human solid tumors. In this study, investigators implanted human prostate cancer cells, which are highly metastatic to bone, directly into the leg bone marrow of experimental mice in order to simulate a bone metastasis. A wee...

U-M researchers use nanoparticles to target brain cancer

...s can be used to image and track tumors as well as destroy them, according to researchers at the University of Michigan Comprehensive Cancer Center. Researchers incorporated a drug called Photofrin along with iron oxide into nanoparticles that would target cancerous brain tumors. Photofrin is a type of phot...

New engineered drug may offer prolonged arthritis relief

...ed to find that the same inflammatory enzymes that destroy joint collagen also chew ELP from the original drug protein, thereby restoring its activity. "With the ELP tag gone, you get back your originally active drug," Shamji said. "That finding was pretty unexpected," Setton added. "We hadn't intentiona...

PNAS study reveals why organs fail following massive trauma

...st disease. They swarm to the injury to engulf and destroy bacteria with toxic molecules and biochemicals. Because these same molecules and chemicals are also toxic to nearby human cells, the innate response is normally shut down quickly by the onset of the more time-consuming, precise and thorough adaptive ...

Effective HIV control may depend on viral protein targeted by immune cells

...tivity of the CD8 T lymphocytes that recognize and destroy virus-infected CD4 T cells, the fact that even patients in the last stages of AIDS can have measurable CD8 responses indicates that those responses are not always effective. To investigate how variations in CD8 response alter the ability to control ...

Innovative movies show real-time immune-cell activity within tumors

...ed T cell populations will specifically target and destroy the patient's cancer. To date, despite a few remarkable successes, these trials have proven frustratingly uneven. Greater insights into the mechanisms of interaction between T cells and tumor cells could provide vital new information to advance these...

Gene therapy for hereditary lung disease advances

... lungs by counteracting inflammatory products that destroy lung tissue. But about 100,000 Americans have alpha-1 antitrypsin deficiency, according to the Miami-based Alpha-1 Foundation, a national not-for-profit organization devoted to finding a cure. In addition, medical authorities suspect less than 5 perc...

NASA study: Alaskan fires affected Houston air quality in 2004

...creased rates of asthma among children, and it can destroy plants and reduce crop yields. Federal regulators have given the Houston-Galveston region until 2007 to comply with federal air-quality standards for ground-level ozone, under the threat of severe economic sanctions, including loss of federal highway...

New data from NIH lab confirms protocol to reverse type 1 diabetes in mice

...t suppresses the activity of the immune cells that destroy islets in type 1 diabetes. They also introduced donor spleen cells to retrain the immune system not to attack islets and found that the protocol not only halted the immune destruction caused by diabetes but also allowed the insulin-producing pancrea...

Cancer stem cells linked to radiation resistance

...ncer worldwide. Although aggressive treatments can destroy the majority of the cancerous cells, a small fraction of them remain and often regenerate into even larger masses of tumor cells. Until recently, scientists knew little about what made these resistant cells different from those that succumb to rad...

Insulin receptor stops progression of Alzheimer's disease

... Streptozotocin (STZ), a compound that is known to destroy insulin producing cells in the pancreas and cause diabetes. When injected into the brains of rats, the compound mimicked the neurodegeneration of Alzheimer's disease ?plaque deposits, neurofibrillary tangles, diminished brain size, impaired cognitive...

Five new technologies that promise to transform medicine

...arts, and the use of miniature robots to track and destroy infections before they cause disease. The individual and collective impact of these technologies is already present in some aspects of contemporary medicine and the rate of their impact is increasing, he concludes....

Gene therapy study takes aim at prostate cancer

...temic immune response, we are enabling the body to destroy prostate cancer cells that have moved elsewhere," he said. Kadmon and his colleagues plan to test six different doses of the gene. The gene therapy involves attaching an inactivated adenovirus (related to viruses that cause respiratory infections) ...

A new jump start for aging blood vessels

...ased levels of TNFa, a protein that can attack and destroy tumor cells but can also exacerbate chronic inflammatory diseases. To date, no studies have investigated the potential beneficial effects of TNFa inhibition in vascular aging, making this the first study of its kind. Csiszar and collegues treat...

Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax

...ted by host white blood cells that would otherwise destroy it, thus allowing anthrax infection to progress. The toxins are thought to act mainly by damaging defensive cells called phagocytes, causing the immune system to malfunction. The organism then spreads unimpeded to all major organs of the body, causin...

Targeted virus compels cancer cells to eat themselves

...part of themselves when nutrients are scarce or to destroy some of their organelles to recycle their components. A double membrane forms around the material to be consumed, then everything inside is digested. Kondo and colleagues showed that hTERT-Ad (short for human telomerase reverse transcriptase promote...

Scientist works to improve treatment for brain tumors

...demar Debinski, M.D., Ph.D., pioneered a method to destroy cells of glioblastoma multiforme (GBM) with less damage to healthy cells. The drug is currently being tested in clinical trials and Debinski is working on its fourth generation in the laboratory. With the grant, Debinski will work to identify the be...

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