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Tag: "designed" at biology news

Genomic Analysis Uncovers New Targets for HIV Vaccine

...ing to Goldstein, who said that a vaccine could be designed to elicit an HLA-C mediated response which HIV-1 m...ore effective vaccines." Added Haynes: "CHAVI was designed to do big science, and the results of this analysis represent just the first of what should be many ...

One species, many genomes

...r sleuthing they used almost one billion specially designed DNA probes. "All together, these probes would have...ct. The data were evaluated with several specially designed statistical methods, including a variant of machine learning. The result of this painstaking analy...

Research identifies protein that signals flowering in squash plants

... flower unless it is induced. Then, with carefully designed grafting experiments, we can precisely control the introduction of putative florigenic signals into the translocation stream.” The authors screened nearly one hundred accessions of Cucurbita species to identify one, belonging to the undomesticated sq...

Brain inflammation may be friend, not foe, for Alzheimer's patients

...use, then applied the technology in mice specially designed to develop Alzheimer’s disease. The mice developed normally for six months. Then Shaftel raised the level of IL-1beta in one part of the brain –the hippocampus, an area of the brain that specializes in memory and one of the first parts of the brai...

Releasing fish for the future

...ght and then released by anglers. Some guidelines designed to improve fish survival were recently developed f... money from licence fees), is developing protocols designed to maximise fish survival via subtle changes to management practices. Owing to bag limits, legal ...

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

..., providing insight into how future drugs might be designed to effectively kill the parasite," said Paul Roepe, Ph.D., a professor in the Department of Biochemistry and Cellular & Molecular Biology as well as the Department of Chemistry. Any animal with red blood cells can develop malaria, which is ca...

Studies to find better ways to preserve human eggs, ovarian tissue under way

...c chemotherapy and more focused radiation therapy, designed to kill rapidly spreading cancer cells, also can destroy dynamic reproductive tissue. “I don’t think when you are faced with the reality that you may die, your fertility is the most important thing you are thinking or talking about, but there are...

In mice, drug protects against diabetes and atherosclerosis

...h Hotamisligil cautioned that experiments were not designed to look for such effects rigorously. While it is not certain that the experimental compound or others like it can be developed into successful drugs for humans, Hotamisligil described the animal results as a long-sought success after a decade of i...

U-M researchers discover gene switched off in cancer can be turned on

...find a better way to turn it back on. No drugs are designed to deal with a gene that’s turned off. But it’s a straightforward extension of current therapies that target genes that are turned on,” says lead study author David Reisman, M.D., Ph.D., assistant professor of internal medicine at the U-M Medical Sch...

Undergraduate research shows leaderless honeybee organizing

...ences for undergraduates. Using an ingeniously designed experiment, Pierce and his co-authors were able to document details of bee social behavior that fundamentally confirm the hypothesis that major colony activities are initiated by the cumulative group actions of the colony’s older workers, not by the...

Massive herds of animals found to still exist in Southern Sudan

... of wildlife and the protected areas network being designed by the Ministry of the Environment, Wildlife Conservation, and Tourism and the Wildlife Conservation Society will be a key component of the overall development of Southern Sudan.”...

Genetic factors are linked to fever following smallpox vaccination

...dult diseases,” Dr. Stanley remarked. “Our work is designed to identify ways we might make vaccines even more acceptable in the future by discovering ways to further reduce the chance of minor adverse events.” In an accompanying editorial, James E. Crowe Jr., MD, of Vanderbilt University Medical Center, ...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

... other cargo into cells. "The released cargo is designed to be transported to different locations in the cells to carry out disease detection and treatment simultaneously," said Bashir, a professor in the Weldon School of Biomedical Engineering and the School of Electrical and Computer Engineering. "Becaus...

In nature, proteins sweep up nanoparticles

...could play a key role in bioremediation strategies designed to trap harmful metals such as arsenic, lead, uranium, and plutonium. “We have found, in the environment, that cells release proteins and polypeptides which promote the aggregation of nanoparticulate metals,” says John Moreau, lead author of the s...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

...ls protect themselves, cancer therapies have to be designed specifically to target cancer stem cells while sparing normal stem cells,” she explained. ...

Mutating the entire genome

...ology is very good at changing any given gene in a designed manner,” Capecchi says. “The negative side is, it takes work and money to do that.” The new method is “a cheaper way of knocking out a gene as well as regulatory sequences.” Capecchi says it now costs about $10,000 to genetically engineer a mouse...

3-D ultrasound scanner provides in-depth view of the brain

...eported the development of a 3-D ultrasound device designed for imaging the heart and other internal organs during endoscopic surgeries performed through tiny "keyhole" incisions about 3 centimeters in diameter (http://www.pratt.duke.edu/news/"id=417). To make the probe more suitable for brain scanning, the r...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

...disease. The Phase 1 study was not specifically designed to assess efficacy. Nonetheless, the researchers reported the clinical outcomes to be very encouraging, with treated patients showing significant improvement in both the “on” and “off” states of their illness (the time periods in which they achieve o...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

...y, researchers found that one injection of a newly designed gene therapy relieved 100 percent of osteoarthriti... toxins and hormones around them. Each receptor is designed to react with a specific signaling molecule, which docks into the receptor like a ship coming into p...

HIV and malaria combine to adversely affect pregnant women and their infants

...nslate this knowledge into more effective vaccines designed to generate these types of protective antibodies."...

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