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Tag: "design" at biology news

Computer simulation hints at new HIV drug target

...aceutical or biotechnology companies to pursue the design of a new kind of inhibitor," Perryman said. "We ar...rotease inhibitors. Other scientists are trying to design drugs to bind to the whiskers and or to lock down the flaps by binding to their top. Perryman's fi...

How sperm crack the whip

...s both recognize new forms of male infertility and design new contraceptives to thwart sperm entry into the egg. What's more, they said, the exquisitely delicate analytical technique they used to eavesdrop on the electrical currents inside the squirming sperm cell could literally open a new window into its...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...aceutical or biotechnology companies to pursue the design of a new kind of inhibitor," Perryman said. "We ar...rotease inhibitors. Other scientists are trying to design drugs to bind to the whiskers and or to lock down the flaps by binding to their top. Perryman's fi...

Scientists make first step towards 'holy grail' of crystallography

...s, collaborated to develop a theory concerning the design of porous materials for protein crystallisation and put it into practice. The theory is based on the rational that the porous structure of a material, traps the protein molecules, and encourages them to crystallise. They tested the theory using BioG...

Berkeley researchers lay groundwork for cell version of DNA chip

...ologies, the growing of artificial tissues and the design of neural networks. "Just as DNA chips revolutionized genome analysis, we hope to make cell chips (self-assembled arrays of cells on a thumbnail-sized chip) using our DNA-based cell adhesion strategy," said Ravi Chandra, a researcher affiliated with...

Salk researchers make fast strides towards understanding how our body controls walking

...s of walking should put us in a better position to design treatments or implants that restore or activate these pathways," said Martyn D. Goulding, Ph.D., a professor in the Molecular Neurobiology Laboratory. The Salk research team ?led by Goulding?published their findings in the March 9, 2006 issue of the...

Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate

... and it could become the starting molecule for the design drugs for the prevention of human aging-related diseases. ...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

... tissues and may have substantial significance for design of more effective therapeutics for one of the most lethal types of tumor, malignant gliomas. Stem cell factor (SCF) is an important growth factor for multiple cell types. Research has shown that SCF is expressed in glioma cells and as a result of v...

Groovy protein essential for promoting cancer development

...s to immortalize cells ?and should help scientists design broadly effective cancer drugs. Until now, the lack of detailed structural information about the enzyme has hindered progress in developing agents to inhibit it, say the researchers, who published their findings in an advance online publication in ...

Report lists top 20 most-vulnerable African carnivores

...s to immortalize cells ?and should help scientists design broadly effective cancer drugs. Until now, the lack of detailed structural information about the enzyme has hindered progress in developing agents to inhibit it, say the researchers, who published their findings in an advance online publication in ...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...s XmAb TM technology, which couples computational design algorithms with high-throughput screening to rationally design the antibody constant region. The Fc portion of the constant region of the antibody has been shown ...

Molecular force field helps cancer cells defend against attack

...f different ways. For example, we might be able to design drugs that mimic this area of binding and disrupt it in patients." Because normal cells generate much lower levels of FAK than tumor cells do, treatments could be developed to target FAK and VEGFR-3 at dosages markedly less toxic to healthy tissues ...

How to grow a bigger brain

... a large-scale way." The results could affect the design of hatcheries for breeding fish to restock wild populations, Kihslinger said. The study is published in the February 2006 issue of the Journal of Experimental Biology. Wild steelhead lay their eggs in gravel nests on the riverbed. After hatching, th...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

... cancer cells. The findings may help researchers design a new generation of anti-cancer drugs that selecti...al Inorganic Chemistry researchers reported on the design of a new trinuclear platinum compound and demonstrated that its cellular absorption is significantly...

Common molecular 'signature' identified in solid tumors

...over again in various forms of cancer will help us design new and better interventions," says Croce. MiRNAs can behave like oncogenes, which promote tumor growth, or tumor suppressors, which keep potentially malignant cells in check. Croce points out that miRNA activity is tissue-sensitive, meaning some m...

Oxidation defense in mosquitoes benefits malaria parasite

...hway will be used for the structure-based rational design of potent and highly selective inhibitors of poten...minase. The research will continue on the rational design of a small molecule that could be synthesized, and that would allow the malaria cycle to be interrup...

New device could cut chemotherapy deaths

...oncology team at the Royal United Hospital for the design and development of these drug delivery vehicles. This team includes Dr Ed Gilby, one of the most experienced consultant oncologists, surgeons Mr Nicholas Johnson and Mr Kenneth Jaaback, clinical trials experts and specialist nurses such as Tracie Mil...

Researchers find molecular 'brake' to cell death

...-destruction - an advance they say may help in the design of more targeted cancer therapies. In the Jun...eoretical approach that can be used to help in the design of more targeted chemotherapy drugs," Tang says. "This will change the way that scientists now think...

New fruit fly protein illuminates circadian response to light

...e human clock responds to light and may be able to design drugs to treat jetlag," concludes Sehgal. ...

New protein target may advance design of HIV and cancer drugs

... The process, active site displacement, involved design of a platinum drug with higher affinity for the pr...pment of anticancer drugs, the researchers hope to design more specific clinical agents with reduced side effects compared to the very useful, but toxic, cisp...

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