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Tag: "design" at biology news

Association of herpesvirus with lung disorder questioned

...no and colleagues conducted their research using a design similar to that in the earlier study: a retrospective analysis of pathology specimens from a small number of subjects. They looked for evidence of HHV-8 in samples of lung tissue from 10 patients diagnosed with primary pulmonary hypertension at a Tok...

Columbia research lifts major hurdle to gene therapy for cancer

... cancers."What's exciting is we may now be able to design a therapy that willseek out and destroy only cancer cells," said the study's seniorauthor, Paul B. Fisher, Ph.D., professor of clinical pathology andMichael and Stella Chernow Urological Cancer Research Scientist atColumbia University Medical Center....

Plants, animals share molecular growth mechanisms

...n this process eventually may allow researchers to design plants better able to protect themselves from insects and disease. "These genes and their proteins are required for normal development and for normal cell-to-cell adhesion," Szymanski said. "They affect the growth of the whole plant and also the sha...

Research advances quest for HIV-1 vaccine

...have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS....lar level and transferring this knowledge into the design of vaccines capable of stimulating broadly neutralizing antibodies against globally diverse HIV. Acc...

Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering

..., bovine, chicken, andporcine."By underwriting the design fees required to produce these new arrays,Affymetr...rogram arrays are developed using the samereliable design and manufacturing process that have made Affymetrix theindustry-standard technology for gene express...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...otic resistance, it still remains a target for the design of new anti-TB drugs. "Enzymes that synthesize mycobactin are drug targets, because if mycobactin biosynthesis is stopped, the bacterium cannot acquire the iron that it needs for survival," explains Dr. Baker. "Importantly this seems to be true even ...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...hat makes infection moresevere. It may lead to the design of new toxin inhibitors. “Blocking orinterfering with a bacterium’s “detection?mechanism, should preventtoxin production and limit the severity of infection,?says MichaelGilmore, PhD, lead author of the study, and currently director ofresearch at the...

Molecular machine may lead to new drugs to combat human diseases

..., forming a functional gene," Golden said. "We can design introns and re-engineer them so they will do this to RNA in which we're interested." Once thought of as genetic junk, introns are bits of DNA that can activate their own removal from RNA, which translates DNA's directions for gene behavior. Introns ...

Female sex hormones play a vital role in defense against sexually transmitted diseases

... McMaster researchers are currently discussing the design of a study with infectious disease clinicians in Hamilton, which may begin in as early as the next few months. Additionally they will be looking at issues of co-infection with both HIV-1 and HSV-2 which is a big problem clinically. The two studies w...

Spider Venom Could Yield Eco-Friendly Insecticides

... His next challenge is to use this information to design insecticides that specifically target insect pests without affecting vertebrates. One approach is to create chemical insecticides that mimic the action of spider toxins. Many insects have developed immunity to DDT and other chemical controls because ...

Open microfluidic and nanofluidic systems

... photolithographic methods, represent an appealing design principle for such microcompartments and, thus, pr...tract liquid in a convenient manner. An appealing design principle for such microcompartments is based on open and, thus, directly accessible surface channel...

Study shows nanoshells ideal as chemical nanosensors

...yof Nanophotonics. "That creates an opportunity to design all-opticalnanoscale sensors -- essentially new molecular-level diagnosticinstruments -- that could detect as little as a few molecules of atarget substance, which could be anything from a drug molecule or a keydisease protein to a deadly chemical ag...

Development of portable infectious disease detector

...a coffee cup.One of the cost-saving aspects of the design was to keep thefluid-handling components separate from the microelectronics. Theresulting device is considerably larger than comparable lab-on-a-chipsystems but it is also much less expensive. "That's one of theappealing features about Pria's approac...

Research Gives Hope For Liver Damage

...ng. Exciting insights suchas these will inform the design of future therapies."Further research into macrophages is set to follow and scientists willexplore the role of these immune-system cells in damage and repair toother organs, including the kidney....

UCSD discovery may help extend life of natural pesticide

...nsect pests. Their findings should facilitate the design and use of Bt toxins to prevent insects, which the researchers believe also possess the molecule, from developing resistance to Bt, extending the life of this natural pesticide. The study, published February 11 in the journal Science, details the st...

Study of genomic DNA leads to new advances in cancer diagnostics

...evel. These findings may provide the basis for the design of a new generation of cancer therapeutic agents. Research was funded by the National Institute of Health and the Department of Energy. This work involved collaborators at the University of Illinois at Chicago Department of Pathology, the Universit...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

...pproach will have a very beneficial impact on drug design and human health." ...

Scientists solve structure of key protein in innate immune response

...4. Now, drug developers will have better chance to design a molecule that will complement the shape of the pocket." ...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

...of effort in the Therien laboratory focused on the design of highly fluorescent compounds. Polymersomes, which were developed by Penn professors Daniel A. Hammer and Dennis Discher in the mid-1990s, function much like the bilayered membranes of living cells. Whereas cell membranes are created from a double ...

Molecular models advance the fight against malaria

...ions, we have created a practical research tool to design new, improved versions of the drug using these res...ter the effects of atovaquone, researchers can now design new anti-malarial drugs with features making the appearance of resistance more unlikely. "Within th...

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