New insights into autoimmunity and depression
...epression, among other symptoms. Some studies have described a possible link between SLE’s most severe psychiatric manifestation, psychosis, and a protein autoantibody associated with the central nervous system, anti-ribosomal P. To investigate how an autoantibody could stimulate behavioral changes by inter...Clues to gene expression in cystic fibrosis will guide research
...ator (CFTR) protein. Over 1500 mutations have been described since this gene’s discovery. Premature stop mutations, which includeY122X, are found in around 10% of CF patients. Gentamicin reversed stop codons in the Y122X gene, and helped restore the CFTR protein, improving patients?respiration. Gentamicin i...Does evolution select for faster evolvers?
...ng favorable mutations across populations. Deem described the importance of horizontal gene transfer in the work in a January 2007 cover story in the Physics Today, showing how HGT compliments the modular nature of genetic information, making it feasible to swap whole sets of genetic code ?like the genes th...Protein averts cell suicide but might contribute to cancer
...tate University 's Comprehensive Cancer Center are described in two back-to-back papers in The Journal of Biological Chemistry. "Unrepaired DNA damage presents a big roadblock for the DNA replication machinery, which cannot go around it," says Zucai Suo, assistant professor of biochemistry. "This damage wi...A sweet step toward new cancer therapies
...d structurally characterize glycans. Their work is described in the April 15 issue of the journal Analytical Chemistry. Typically, analytical chemists use mass spectrometry---a technique that accurately weighs molecules or fragments of molecules---to analyze proteins. In this process, proteins are introduce...One-of-a-kind imaging probe reveals secrets useful for drug discovery
... eastern United States. The analytical technique, described in the current issue of ACS Chemical Biology by scientists at the McKnight Brain Institute of the University of Florida and the Center for Medical, Agricultural and Veterinary Entomology at the Gainesville U.S. Department of Agriculture, could aid in...Math model predicts cancer behavior
...oped a computational model for cancer invasion and described the model in the Dec. 1 issue of Cell. The model ?a series of mathematical equations that drive computer simulations of tumor growth ?suggests that the microenvironment around tumor cells determines the tumor's ultimate cellular makeup and invasive p...Gold nanoparticles prove to be hot stuff
...ion of smaller motions at the same laser power. As described in the Aug. 15 issue of Optics Letters,* the JILA team demonstrated that 100-nanometer-wide gold beads, as expected because of their metallic nature, can be trapped and detected six times more easily than polystyrene particles of a similar size. Ho...Underweight women at greater risk of miscarriage
...emination or artificial insemination. Women who described their pregnancy as 'planned' had 40% reduced odds of miscarriage. But within this group, those who took more than a year to conceive were twice as likely to miscarry as those who had conceived within three months. The authors found confirmation f...Comprehensive model is first to map protein folding at atomic level
... thousand times longer than previous methods -- is described this week in the Proceedings of the National Academy of Sciences. "For years, a sizable army of scientists has been working toward better understanding how proteins fold," says co-author Eugene I. Shakhnovich, professor of chemistry and chemical b...New bird discovered on unexplored Columbian mountain
... latinuchus yariguierum. The new brush-finch was described by an Anglo-Colombian team of biologists including...flies, we have found several new taxa that will be described soon." The new bird discovered was funded due to an on-going commitment to the environment from B...Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia
...Sciences (formerly Cook College). "But we have now described a specific example demonstrating the common heritage. That specific example, an enzyme that supports protein production, could lead to antibiotics specific for this form of STD." The discovery is an unexpected turn in solving the mystery of how pl......ts. This is the widest diversity of symbionts ever described in a bivalve species," said Duperron. This means that the mussel, depending on which type of symbionts it carries, can derive its energy from either sulphide or methane. In addition, Duperron has also found that in the Idas sp., three of the symbi...Fantastic Voyage: A new nanoscale view of the biological world
...atment drug there is within a cell. New technology described in a study published today in the open access journal Journal of Biology makes it possible to image and quantify molecules within individual mammalian or bacterial cells. Claude Lechene and colleagues describe the development of multi-isotope imaging...'GreeneChip' -- New diagnostic tool that rapidly and accurately identifies multiple pathogens
...microorganism in a fatal hemorrhagic fever case is described in the January 2007 issue of the CDC’s Emerging Infectious Diseases (online December 6 at www.cdc.gov/EID/13/1/06-0837.htm ). Globalization of travel and trade brings new infectious agents into new contexts. It is increasingly important to be pre...Researchers develop technologies to devour food pathogens
...le," Linton said. Bhunia's technology is further described in an article published this summer in the Journal of Biomedical Optics. Linton and Morgan have been working with chlorine dioxide for years, and have several published studies, one of which appeared in the Journal of Food Protection in 2004....First major study of mammalian 'disorderly' proteins
...em." Unlike the classic description of proteins described in science textbooks, IUPs are not completely locked into rigid, 3-D shapes that determine their function in the cell. Instead, IUPs have varying amounts of flexibility within their sometimes spaghetti-like structures that is critical for function. F...Fast-freeze snapshot yields new picture of nerve-muscle junction
...bles nerve cells to issue commands. The technique described in the new study, high-pressure freeze electron microscopy and immuno-gold staining, now provides an accurate picture of where these synaptic proteins cluster -- information previously unknown to scientists. Co-author Robby Weimer, a post-doctoral ...Researchers identify new weapon to fight deadly bacterial sepsis
...ava and his UTMB collaborators (including research described in a paper published Oct. 1 in Cancer Research) has demonstrated that blocking aldose reductase similarly can dramatically reduce the inflammation-driven processes of colorectal cancer and complications of diabetes. "There are so many inflammatory...Lab-on-a-chip could speed up treatment of drug-resistant pneumonia
...ineer at the Denver biotechnology company Accelr8, described a new lab-on-a-chip that can identify single bacterial cells for the most common cases of drug-resistant pneumonia, cutting down the wait from days to hours. The technology could also help in the development of new drugs. The constant bombardment by...