Tamoxifen-like drug suggests new ways to selectively block estrogen
...dely used to treat and prevent breast cancers that depend on estrogen. But it has the opposite effect in the uterus, acting like estrogen to stimulate tissue growth and increasing the risk of uterine cancer. A newer group of drugs, known as selective estrogen receptor down-regulators, or SERDs, have a more...Understanding how bacteria communicate may help scientists prevent disease
...eople realize that other important activities also depend upon a quorum, such as biofilm formation, releasing toxins, or becoming a virulent invader," said Rahul Kulkarni. While Kulkarni works with Vibrio cholerae as a model bacteria, quorum sensing appears to be a universal process in bacteria. So what he ...Unique library of plant genes germinates, takes root at UNC
...e to improving crops that humans around the planet depend on every day, its developers say. Named Phytome, the unique library is a compilation of voluminous genetic data on 39 plant species. The list includes almost all the world's most valuable crops, among them rice, wheat, corn and potatoes. "But it's ...Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton
...o whales--and the success of fishermen catches can depend on their success at finding those patches. For almost a century ocean scientists have suspected that these patches form when the zooplankton swim against the ocean currents. In all those years, however, an understanding of zooplankton swimming respo...Insulin pulses keep the liver lean
...nsulin delivery, suggesting that insulin's effects depend on prior levels of the hormone, the researchers reported. "The current data demonstrate that CEACAM1 is at the intersection of the pathways regulating insulin and fat metabolism in liver," Najjar said. "Although mutations in CEACAM1 have not been f...Secrets of the deep may hold key to life on other planets
...ents in the deep sea - and are unique because they depend on bacteria living inside them for their own survival. These bacteria take their energy from hydrogen sulphide in the vent fluid. "They're among the fastest growing animals on the planet - a full community can grow in just three years," said earth a...Crisis in African fish supplies looms, experts warn Africa leaders
...e success of this new micro-enterprise sector will depend on investment to create effective support services. 3. Improve fish market chains In many parts of Africa, post-harvest losses to spoilage due to inadequate landing, processing and trading sites exceed 30% of the catch. Weak market infrastructur...Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
...e success of this new micro-enterprise sector will depend on investment to create effective support services. 3. Improve fish market chains In many parts of Africa, post-harvest losses to spoilage due to inadequate landing, processing and trading sites exceed 30% of the catch. Weak market infrastructur...Nose odors and mouth odors: The brain distinguishes
...ssibility that the effects of route of stimulation depend on the way that odors are typically sensed," wrote Small and her colleagues. "For example, food odors are normally experienced both orthonasally and retronasally, whereas nonfood odors are perceived only orthonasally. Therefore, it is possible that t...Nanowires can detect molecular signs of cancer, scientists find
...these cancer markers in healthcare will ultimately depend upon the development of techniques that allow rapid detection of many markers with high selectivity and sensitivity. "Genomics and proteomics research has elucidated many new biomarkers that have the potential to greatly improve disease diagnosis," ...Discovery of T-cell 'traffic control' boosts new drug promise
... autoimmune diseases and transplant rejection will depend on developing new drugs that block only the immune type of S1P receptor," he adds. "But early studies by a number of researchers are quite promising." Progress will also come from finding "uniquely effective combinations of these agents with other i...MERIS monitoring tracks planetary photosynthesis levels
...role on Earth as all animals and humans ultimately depend on it for food. Plants often provide a local habitat for other species to live in, and constitute a major source of raw materials for human activities. Wood in particular constitutes a critical source of energy storage for a large fraction of humanit...Unweaving amyloid fibers to solve prion puzzles
...ibrous structures such as amyloids. And scientists depend on these high resolution images of molecules in order to study their function. Now, researchers have found a way to work around these limitations, illuminating the configuration of these sometimes pernicious molecules. And even though this work was ...UCR biochemist goes to Washington with high-protein corn
...ld provide a good source of protein for those that depend on grain as their primary source of nutrients." Every corn kernel results from a flower on an ear of corn, Gallie explained. Initially the ear produces a pair of flowers for every kernel. But then one of the sister flowers undergoes abortion, result...Traditional models underestimate extinction rates
...edictions reported here. Conservation efforts will depend on developing methods of generating reliable predictions with the limited data available from the field. ### Citation: Drake JM (2005) Density-dependent demographic variation determines extinction rate of experimental populations. PLoS Biol 3(7): e...Researchers find how some antibiotics kill bacteria
...ms by eliminating the symbiotic bacteria parasites depend on. "It's the kind of drug the pharmaceutical business wants to produce," Artsimovitch said. "They're looking for the broadest range of antibiotics possible. Rifamycins would be ideal drugs if we could figure out how to get rid of resistance." ...Computers close in on protein structure prediction
...et reliable enough for biology. Better models will depend on both smarter exploration strategies and more computer power. "If methods stayed where we are, we wouldn't solve the problem," Baker said. "On the other hand, we would do better with 10 times more computer time." It takes less than one minute for ...Learning how SARS spikes its quarry
...son. "And we know that those modes of transmission depend on specific mutations in the spike protein that affect spike-receptor interaction. "One of the critical issues in a SARS epidemic would be to predict whether a given variant of the virus will jump species or move laterally from one human to the oth...Optimizing cell therapy against tumors is a balancing ACT
...ro Romero write, "optimal therapeutic efficacy may depend on different T cell selection and preparation strategies" and these findings indicate that a pragmatic strategy for ACT is to keep the in vitro T cell expansion phase as short as possible to keep them naïve. These findings are important for developme...Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases
...uce infection," Hodge said. Because these viruses depend heavily on this exit pathway, they probably would not be able to find another route out of the cell. This suggests that Rab9 and other components of this exit pathway might be attractive targets for antiviral therapies for a variety of viruses. Bloc...