Tag: "dendritic" at biology news

Source of molecular triggers in cutaneous T cell lymphoma identified

...require antigenic stimuli delivered by specialized dendritic cells of the epidermis, referred to as Langerhans ...tic infections. "Through understanding T cell and dendritic cell interactions, we may gain the ability to manage a spectrum of maladies ranging from cancer to d...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...y homes to specialized immunesystem cells known as dendritic cells, and infects them. Inside,VRP-neu produces high levels of the HER2/neu protein, which thedendritic cells then display on the outside of their cell surface. Thisis, in fact, a neat trick, says Lachman, because the function ofdendritic cells is t...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

...y homes to specialized immunesystem cells known as dendritic cells, and infects them. Inside,VRP-neu produces high levels of the HER2/neu protein, which thedendritic cells then display on the outside of their cell surface. Thisis, in fact, a neat trick, says Lachman, because the function ofdendritic cells is t...

Scientists identify new model Of NK cell development

...mune cells that make those substances ?T cells and dendritic cells ?just happen to reside in lymph nodes, too." Freud also makes the provocative observation that lymph nodes, while full of CD56 bright cells, are significantly lacking in their counterparts, the CD56 dim cells. "Our next goal is to determine i...

Leprosy microbes lead scientists to immune discovery

... DC-SIGN+, while the other, the antigen-presenting dendritic cells, are termed CD1b+). In people who have the form of leprosy known as tuberculoid, or T-lep, the body has made a strong immune response and the infection stays localized to the skin. In patients with lepromatous leprosy, or L-lep, the bacteria ha...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

...he infected cells were macrophages, neutrophils or dendritic cells. These cells make up what immunologists call the "innate" immune system. They are the first to respond to a bacterial invasion. Their role is to rush to the infection site, engulf the bacteria, chew them up into smaller pieces and present thos...

New vaccine protects more effectively against tuberculosis

...cells, which leads to stimulation of protection by dendritic cells, the most efficacious antigen-presenting cells. As a result, stronger protection against pulmonary tuberculosis has been achieved in preclinical studies. Importantly, the new vaccine also protects against clinical isolates of the Beijing family...

'Underground' tunnels discovered as means for communication between immune system cells

...lls use for exchanging information. Blood-derived dendritic cells and macrophages, both antigen-presenting cel... system, they report that, in a matter of seconds, dendritic cells and macrophages can send waves of calcium and other small molecules to cells hundreds of micro...

Researchers report breakthrough against world’s deadliest viruses

...ola and Marburg. "In addition, the vaccine targets dendritic cells, which are the same cells that Ebola and Marburg attack," said Dr. Geisbert. "These cells are also important in generating a protective immune response. So the vaccine goes exactly where we want it to go." The study describes how Canadian rese...

Breast tumors in mice eradicated using cancer vaccine

...nses, activating such immune cells as macrophages, dendritic cells, and T cells. This helps jump-start the immune response to break tolerance. But, why Listeria over other bacteria as a vehicle to deliver a tumor-associated antigen? Because of Listeria's unusual life style. Normally, when bacteria get taken ...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...s team has confirmed that the gene is activated in dendritic cells, whose role is to distribute "look here" inf...ing a drug to block FLT3 gene signaling could stop dendritic cells from triggering harmful responses against a patient's own body," says Donald Small, M.D., Ph.D...

UT Southwestern researchers develop screening test for cells that activate immune system

...lions of compounds to identify those that activate dendritic cells, which are on constant recon patrol througho...to the discovery of several compounds that turn on dendritic cells, which are found throughout the body from skin to blood. They continuously scan the body at th...

New vaccine platform may fight infections with causes from influenza to bioterrorism

...hogen. But antibodies rely on other cells, such as dendritic cells, to capture the antigen and advertise their bounty, which they do by displaying an antigen fragment on their cell surface. Antibodies see this antigen fragment as a mug shot of sorts, and when they recognize the same fragment expressed on the o...

A new window into structural plasticity in the adult visual cortex

...ver the course of four to ten weeks. The length of dendritic branch tips was measured over time to evaluate physical changes in the neurons. Many studies have focused on pyramidal neurons--excitatory neurons that promote neuron firing--but few have focused on the possible structural dynamics of a range of dif...

MIT researcher finds neuron growth in adult brain

...improvement (in spinal cord patients) by embracing dendritic growth." The growth is affected by use, meaning the more the neurons are used, the more likely they are to grow, she said. The study's co-authors -- Nedivi; Peter T. So, an MIT professor of mechanical and biological engineering; Wei-Chung Allen Lee,...

A new step towards an AIDS vaccine

...rsely correlated with the presence of plasmacytoid dendritic cells (pDCs), a subset of the dendritic cell family and the major producers of type 1 interferon in the body. High numbers of pDCs is relat...

Magnetic probe successfully tracks implanted cells in cancer patients

...y. The cells used in the current study, so-called dendritic cells, are the immune system's own "most wanted po...e the mid-1990s, clinical trials have been testing dendritic cells to see whether they can stimulate the immune system to kill cancer cells. In these trials, den...

Scientists observe how a close bond activates the immune system

...gers this complex response begins when T cells and dendritic cells, another type of immune cell, form a kind of...n the lymph nodes. It is a demanding job. "Just 10 dendritic cells can show viral antigens to over a million T cells in a day," says Dr. Dustin. Once a T cell'...

Langerhans cells regulate immune reactions in the skin

... and other foreign materials. Langerhans cells are dendritic cells in the skin. Skin is an important barrier to infection and it has been generally assumed that the Langerhans cells only serve to warn the immune system of skin pathogens. According to the study, featured on the cover of the December 15 issue ...

How the neuron sprouts its branches

...s might play a role." The researchers studied the dendritic growth process in pyramidal neurons, which grow a ...he Golgi outposts appeared to locate themselves at dendritic branch points. "This finding is important because a fundamental problem that neurons must solve is ...

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