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Tag: "demonstrated" at biology news

Columbia research lifts major hurdle to gene therapy for cancer

...tional Academy of Sciences (PNAS), the researchers demonstrated thatthe technique works by incorporating it into a specially designedvirus. The virus eradicated prostate cancer cells in the lab and inanimals while leaving normal cells unscathed. Genetherapy based on the new technique should also be effective for...

Novel technology detects human DNA mutations

... and rapid characteristics of this technology were demonstrated withunamplified DNA samples representing all possible forms of three genesimplicated in hypercoagulation disorders.Related : Nanosphere Inc. Technology ...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

Mount Sinai School of Medicine researchers demonstrated that a gel applied in the vagina provides protection from both the human immunodeficiency virus (HIV) and the herpes simplex Virus. The study, presented at the 12th Conference on Retroviruses and Opportunistic Infections, is the first to show that a ...

Lack of enzyme turns fat cells into fat burners

...l."In prior studies, Wakil and his colleagues have demonstrated the effectACC2 has on mice. Mice bred to lack the enzyme can eat a high fat, highcarbohydrate diet without gaining weight, while their normalcounterparts become obese and develop type 2 diabetes."This adds another tissue or organ that helps out in th...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...s that become swellings. Scientists havepreviously demonstrated that such swellings make it difficult orimpossible for nerve-cell branches to send signals.After showing that the swellings were mostly stable in number and sizeover the course of three to seven days, Brendza injected Abetaantibodies directly onto th...

Key molecule in plant photo-protection identified

...s that become swellings. Scientists havepreviously demonstrated that such swellings make it difficult orimpossible for nerve-cell branches to send signals.After showing that the swellings were mostly stable in number and sizeover the course of three to seven days, Brendza injected Abetaantibodies directly onto th...

Timing is everything: First step in protein building revealed

...ates the ribosome's activity.The research team has demonstrated that eIF1's mere presence on theyeast ribosome prevents the machinery from getting started. Only afterits release from the complex can the ribosome start making proteins."No one had any idea when eIF1 was released from the ribosome, or thatits releas...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...h, will I beable to compare both? The NIH recently demonstrated that microarrays experiments performed in different labs "have a high degree of reproducibility , as long as standardized protocols are carefully followed". Good news for the scientific community (and the microarrays producing companies)! A stud...

Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates

...ation of this therapy.These researchers previously demonstrated that mouse embryonic stemcells can differentiate into neurons when cultured under specificconditions. These same culture conditions, technically simple andefficient, were recently applied to primate embryonic stem cells andresulted in the generation ...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

Researchers at Duke University Medical Centerhave demonstrated for the first time what happens inside a cell when...h, seeds andother foods.Their study in yeast cells demonstrated that iron-starved cellspreserve the little iron they possess by shutting down the major ironusers in...

Novel Enzyme Shows Potential As An Anti-HIV Target

...ing cells taken from transgenic mice lacking SIRT1 demonstrated that introducing human SIRT1 enzymes increased Tat’s transcriptional effects in a dose-dependent manner, while treating cells with the small molecule HR73, a derivative of a molecule that inhibits the yeast version of the SIRT1 protein, caused a 5-fo...

An HIV Protein Plays a Surprising Role in Gene Activation

...proceeded as usual in cells lacking TAFs. And they demonstrated that it is Tat—along with its cofactor P-TEFb, which is normally bound to RNA through Tat—that recruits the TAF-deficient TBP. Altogether, these results show a surprising new role for Tat in stimulating assembly of a transcription complex. What's mo...

Automatic extraction of gene/protein biological functions from biomedical text

...nd rule-based techniques. A preliminary experiment demonstrated that our method has an estimated recall of 54?4% with a precision of 91?4% for actually described functions in abstracts. When applied to the PUBMED, it extracted over 190 000 gene–GO relationships and 150 000 family–GO relationships for major eukary...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...e had been rendered nonfunctional, the researchers demonstrated they could introduce the functioning gene and correct glycogen buildup in heart and skeletal muscle. The findings suggest that such an approach should be considered as a potential gene therapy strategy for Pompe disease patients, the researchers repo...

Purdue proves concept of using nano-materials for drug discovery

Researchers at Purdue University have built and demonstrated a prototype for a new class of miniature devices t... a reaction and turning blue in the process, which demonstrated that the device works. The Center for Membrane Protein Biotechnology combines a diverse range of re...

Essential mangrove forest threatened by cryptic ecological degradation

...rnational team led by Dr. Farid Dahdouh-Guebas has demonstrated that in the recent past an increase in human-environment interactions that affect the hydrology of rivers has turned coastal mangrove lagoons into freshwater bodies. Such elucidation of past ecosystem processes and human-environment interactions is ...

Vital step in cellular migration described by UCSD medical researchers

...'s immune response to invading pathogens, has been demonstrated by researchers in the University of California, San Diego (UCSD) School of Medicine. Published in the March 27 online edition of Nature Cell Biology and the journal's upcoming April print edition, the study describes how a the interaction of alpha4 i...

Critical role in programmed cell death identified

...als with a cell death defect die. The researchers demonstrated that when they cause worm mitochondria to fragment without instructing cells to die, the cells still die and when they block fragmentation, the cells survive; in other words, blocking fragmentation prevents cell death, inducing fragmentation provokes...

Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses

...econds, all agents with the exception of handwipes demonstrated a 90 percent reduction of bacteria on the hands." Alcohol-based handrubs were generally ineffective in demonstrating a significant reduction of a relatively resistant virus, Rutala said. While the use of alcohol-based handrubs will continue to be an...

Genetically modified natural killer immune cells attack, kill leukemia cells

...he current online issue of Blood. The researchers demonstrated how to overcome significant technical hurdles that have until now slowed development of NK-based therapies for ALL, according to Dario Campana, M.D., Ph.D., a member of St. Jude Hematology-Oncology and Pathology, and senior author of the Blood report...

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