First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
Chicken-produced antibodies demonstrate enhanced cell killing compared to conventionally produced anti-cancer antibodies Origen Therapeutics today announced the first published scientific report of fully functional, human sequence monoclonal antibodies (mAbs) produced in chickens. The ant...Anthrax test, developed by army and CDC, receives FDA approval
...., commander of USAMRIID. "Successes such as these demonstrate that we can translate our research efforts into products for our health care providers and clinical laboratory professionals." ...'Mad cow' proteins successfully detected in blood
...., commander of USAMRIID. "Successes such as these demonstrate that we can translate our research efforts into products for our health care providers and clinical laboratory professionals." ...New insights into how Huntington's disease attacks the brain
...se. "This is the first direct genetic evidence to demonstrate that abnormal interactions between cells can significantly contribute to brain cell death in a living mouse model of Huntington's disease," said Yang. Yang's team is now trying to pinpoint which of the neighboring cells generate Huntington's disease...Researchers develop new method for facile identification of proteins in bacterial cells
.... The researchers used a dioxin-eating organism to demonstrate the capabilities of their methodology, which they ...oomberg School of Public Health and his colleagues demonstrate how PMF and mass spectrometry are used to identify a unique dioxin-degrading enzyme in a soup of hun...Novel compounds show promise as safer, more potent insecticides
...cording to the researchers. They were the first to demonstrate the mode of action of these ryanodine receptor-active molecules, says Daniel Cordova, a researcher at DuPont Crop Protection. Both classes of compounds are believed to have high potency, the researchers say, although they are structurally different....Identification of specific genes predicts which patients will respond to Hepatitis C treatment
...rned on or turned off - of 18 genes. "Our results demonstrate that a relatively small number of genes can predict response to therapy. These genes may be important to the ability of the patient to eliminate the virus, so studying these genes in more detail will hopefully lead to novel antiviral treatments," sai...Bacteria use host's immune response to their competitive advantage
...e the competitor," says Weiser. The findings also demonstrate how antibiotics and vaccines that target one microbe might inadvertently alter the competitive interactions among other species present. ### Citation: Lysenko ES, Ratner AJ, Nelson AL, Weiser JN (2005) The role of innate immune responses in the out...Scientists track stealth DNA elements in primate evolution
...rs to examine the Yb subfamily of Alu elements, to demonstrate that the Yb subfamily has a similar evolutionary pattern to that of AluYa5, and to formulate the "stealth driver" hypothesis for the evolution of these Alu elements. "In contrast to 'master' genes, 'stealth drivers' are not responsible for generatin...OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies
...r humans. Finally, studies need to be conducted to demonstrate that giving pregnant women higher levels of vitamin C will not itself cause development problems. The ONPRC is a registered research institution, inspected regularly by the United States Department of Agriculture. It operates in compliance with the ...Insulin pulses keep the liver lean
...mone, the researchers reported. "The current data demonstrate that CEACAM1 is at the intersection of the pathways regulating insulin and fat metabolism in liver," Najjar said. "Although mutations in CEACAM1 have not been found in patients with diabetes or insulin resistance, it is tempting to speculate that CE...Looks matter to female barn swallows
...n signals of male quality, like coloration, and to demonstrate that mate-selection decisions are continual and dynamic. The results of the study have implications for the evolution and upkeep of showy ornamental traits -- such as a peacock's tail or a deer's antlers -- that are costly for males to maintain but g...Micro-molecule plays big role in birth defects
... at limb development because it's a great place to demonstrate the technique," said Brian Harfe, Ph.D., an assistant professor of molecular genetics and microbiology in the College of Medicine and lead author of the report. "We were able to show it's feasible to eliminate the activity of microRNAs from a specifi...Nicotine triggers the same brain reward circuitry as opiates
...y from nicotine and opiates. "The present results demonstrate that nicotine-associated environmental stimuli can activate the same molecular signal transduction molecules as the drug itself," wrote Blendy and her colleagues. They wrote that the activation of CREB "is evident not only after acute and repeated ni...Researchers devise new technique for creating human stem cells
...ells and a different human embryonic cell line, to demonstrate that their technique was not restricted to one adult cell type or embryonic cell line. In both cases, the researchers observed extensive reprogramming of the somatic cells. "We were surprised at how complete the reprogramming was," said Eggan. "I t...Hybrid grass may prove to be valuable fuel source
...ultural Sciences. The next step, Long said, is to demonstrate how Miscanthus goes from a plant to a power source. Existing U.S. power plants could be modified to use Miscanthus for fuel as in Europe, he said. Long collaborates with researchers at the Institute of Genomic Biology to study whether Miscanthus cou...Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy
... the absence of dystrophin, and the first study to demonstrate a new, promising approach to repair the damage. The study's authors emphasize, however, that several years of additional animal research will be required before the treatment could be tested in human patients. "Most people think of the heart as a pu...3D Atlas Will Help Navigate The Spinal Cord
...elevant comparisons with the human spinal cord and demonstrate the anatomical principles or generalizations of its organization, and (c) provide the 3D stereotaxic space designed to become the knowledge management environment for experimental and, eventually, clinical observations. Though not itself directed at...Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease
...e the primary objective of any Phase I trial is to demonstrate safety, the FDA's requirement of unilateral infusion of AAV-GAD allowed us the unique opportunity to compare treated and untreated sides of the brain. In essence, the untreated side acted as a control. The combined clinical and imaging data provide......ses a serious question over how the US is going to demonstrate its compliance with obligations under the Biological Weapons Convention if it brings these tanks online," saysAlan Pearson, programme director for biological and chemical weapons at the Center for Arms Control and Non-Proliferation in Washington DC. ...