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Tag: "demonstrate" at biology news

Novel technology detects human DNA mutations

...rcode for ultra sensitive detection of proteins -- demonstrate the broad applicability of nanotechnology and its potential to markedly advance the state-of-the-art in nucleic acid and proteomic research anddiagnostics."The analysis of whole human genomic DNA is extraordinarily complex asit requires sifting throu...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...owever, in vitro biochemical assays have failed to demonstrate aminoglycoside N-acetyltransferase activity in Rv1347c. By solving the three-dimensional structure of Rv1347c, Dr. Baker and his colleagues have discovered that the enzyme most likely plays an entirely different role in M. tuberculosis. "What the st...

Ants Genetic Engineering Leads To Species Interdependency

...n a new study, Dr. Sara Helms Cahan and colleagues demonstrate thatboth of the species involved have effectively given up the ability toproduce pure-species workers in favor of the hybrids, thereby becomingcompletely dependent on one another for survival.Female ants are generally found in two forms: reproductive...

Alcohol's effects on gene expression in the central nervous system

...added McBride, findings presented at the symposium demonstrate the quantitative and qualitative applications of microarrays to studying the genetic and biological bases of alcoholism and alcohol abuse within discrete brain regions. "For researchers, microarray technology has the potential of studying the geneti...

Scientists document complex genomic events leading to the birth of new genes

... of which are believed to be fully functional. To demonstrate that RGP-family genes have functions that are significantly divergent from those of RanBP2, Bork and his co-workers examined the subcellular localization of one of the RGP-family isoforms. In contrast to RanBP2, which is found exclusively at the nucl...

Scientists solve structure of key protein in innate immune response

... site for LPS because previous biochemical studies demonstrate that amino acid residues comprising the pocket are critical for LPS binding. Most, if not all, of the CD14 ligands compete with LPS for CD14 binding. Therefore, they probably share the same binding pocket with LPS." Ligands other than LPS can be acc...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

...l-like vesicles." In their study, the researchers demonstrate how they can use these emissive polymersomes to target markers on the surface of a specific type of tumor cells. When exposed to near-infrared light, which can travel through tissue, the fluorophores within the polymersome respond with a bright near-...

Genetically modified rice in China benefits farmers' health, study finds

...cultivating the insect-resistant GM rice varieties demonstrate that when compared with households cultivating non-GM rice, small and poor farm households benefit from adopting GM rice by both higher crop yields and reduced use of pesticides, which also contributes to the improved health of farmers." China began...

Variation in women's X chromosomes may explain differences among individuals, between sexes

...others, an additional 10 percent of X-linked genes demonstrate variable patterns of inactivation and different levels of activity in the "silenced" X chromosomes, the team reported. "The findings suggest a remarkable and previously unsuspected degree of expression heterogeneity among females in the population,"...

Substance protects resilient staph bacteria

...to's group also used mice fitted with catheters to demonstrate that the S. epidermidis strain deficient of PGA was not able to cause infection while the other strains containing PGA did. ...

Epstein-Barr virus protein crucial to its role in blood cancers

...a number of EBV-associated cancers. Their findings demonstrate a new mechanism by which EBV transforms human B cells from the immune system into cancerous cells, which can lead to development of B-cell lymphomas. Erle S. Robertson, PhD, Associate Professor of Microbiology and Director of Tumor Virology, with Pe...

Defensins neutralize anthrax toxin

...a number of EBV-associated cancers. Their findings demonstrate a new mechanism by which EBV transforms human B cells from the immune system into cancerous cells, which can lead to development of B-cell lymphomas. Erle S. Robertson, PhD, Associate Professor of Microbiology and Director of Tumor Virology, with Pe...

PGA on a tour under the skin

...to and colleagues from Rocky Mountain Laboratories demonstrate that S. epidermidis secretes an extracellular polymer called poly-gamma-glutamate (PGA) to facilitate growth and ensure survival of the bacteria inside the human host. PGA protects the pathogen from innate host defenses during infection. S. epidermid...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...ore recently begun to emerge. The researchers now demonstrate that lanosterol--an intermediate compound in the s... concentrations, they found. "The current results demonstrate a direct role for lanosterol as a selective, physiologic regulator of reductase ubiquitination and d...

HIV-1 spread through six transmission lines in the UK

...d on transmission rates, but our evidence does not demonstrate this. You would expect growth rates to decrease in the late rather than early 1990s around the time that potent therapy became widely used if this was the case. Instead, we see little correlation between widespread availability of treatment and reduc...

Computational Method Speeds Mapping of Cell Signaling Networks

... largely a "proof of principle" report designed to demonstrate the usefulness of their method, their studies also identified a previously unknown T-cell signaling interaction that connects two pathways. Prediction is the great strength of Bayesian network analysis--particularly in the post-genomic age when rese...

Scientists identify molecule that regulates well-known tumor suppressor

... was associated with poor prognosis. "Our results demonstrate that DJ-1 negatively regulates PTEN function, and that this cell survival control mechanism is conserved among various tissues and species. Taken together, our data suggest that overexpression of DJ-1 can modulate PTEN tumor expression to the point w...

Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive

... than the sex drive." Depression, murder/suicide, demonstrate strength of romantic drive For instance, Fisher point out, "If someone rejects your sexual overtures, you don't harm yourself or the other person. But rejected men and women in societies around the world sometimes kill themselves or someone else. In...

Two are better than one

... the antibody-receptor therapy system. The results demonstrate that with the right combination of antibodies, receptor degradation is accelerated: it's more than three times as effective as a single antibody in inhibiting HER2 signaling. "Understanding how HER receptor degradation works could enhance weak thera...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

...t Chapel Hill (UNC-CH). The study is the first to demonstrate a life-saving treatment for newborns with Krabbe Disease, in which children are missing an enzyme critical to forming the myelin sheath that protects developing brain cells from damage. Moreover, the findings add to the growing body of evidence showi...

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