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Tag: "delivery" at biology news

Biologists discover new pathway into plant cells

...h it. "What that would leave us with is a type of delivery vehicle, a completely new way to deliver compounds...als for hundreds of millions of years. With a new delivery mechanism such as this, applied research could be done either to help or harm plant cells ?by increa...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...) have shown for the first time that targeted drug delivery is possible using nanoparticle-apatamer conjugates...tial to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, thera...

Researchers use 'trickery' to create immune response against melanoma

...) have shown for the first time that targeted drug delivery is possible using nanoparticle-apatamer conjugates...tial to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, thera...

Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods

...s in gastrointenstinal secretions mediated by oral delivery of lipids. These findings unveil one potential pathway mediating fat taste. The data suggest that an alteration in the fat perception system might increase obesity risk through feeding dysregulation. In an accompanying commentary, Nada Abumrad wr...

Access to existing medical treatments could save more lives than spending to improve the treatments

...ficacy, by consuming resources needed for improved delivery of care, may cost more lives than it saves," they wrote. "The misalignment of priorities is driven partly by the commercial interests of industry and by the public's appetite for technological breakthroughs, but health outcomes ultimately suffer." Th...

Needle-free immunizations

...usinesses are focusing on needle-free immunization delivery methods, says Mitragotri, helping ensure that needle-free immunizations will eventually be commonly used. ...

Bioengineers create stable networks of blood vessels

... attraction and repulsion of nerve growth and drug delivery in a model system that can be used in vitro and in vivo." The researchers used two important engineering enhancements to develop stable functional microcirculation. First, they created a "micro-scaffold" of a macroporous hydrogel polymer. The hydrog...

Stem cells from muscles can repair cartilage

...njured cartilage. Tissue engineering involving the delivery of therapeutic proteins to the injured site is a p...ood carriers of a therapeutic gene and enabled the delivery of appropriate amounts of BMP-4 protein to the injury site," they state, adding that the improved re...

Cellular scale drug delivery from the inside out

...may one day be possible thanks to a nanoscale drug delivery system being explored by researchers at the U.S. D...s the structure of the nanospheres that makes drug delivery possible. The spheres have thousands of parallel channels running completely through them. Through c...

Swiss researchers develop all-in-one remote control gene expression tool

...rated them into a single lentiviral vector ?a gene delivery system partly derived from HIV. When injected into... techniques that each previously required separate delivery ?will likely see wide use in genetic research and in clinical gene therapy applications. It is parti...

UC Berkeley researchers create a biologically-inspired artificial compound eye

...eatments that can be controlled by implanted light delivery devices. They are the first hemispherical, three-dimensional optical systems to integrate microlens arrays ?thousands of tiny lenses packed side by side ?with self-aligned, self-written waveguides, that is, light-conducting channels that themselves ...

Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

...ndidate administered using Vical's proprietary DNA delivery technology was safe and well tolerated, and produced both antibody and T-cell Ebola-specific responses in all healthy volunteers who received the full 3 doses of vaccine. The Phase 1, randomized, placebo-controlled, dose-escalation study, the first ...

UCLA scientists find male gene in brain area targeted by Parkinson's

...ie off, they produce less dopamine. This slows the delivery of messages from the brain to the rest of the body, leaving the person unable to initiate or control their physical movements. The condition eventually leads to paralysis. "For the first time, we've discovered that the brain cells that produce dopam...

New RNAi tools enable systematic studies of gene function

...uthor of the study. "For TRC's library, lentiviral delivery is an especially effective means to meet this need." The parallel analysis of thousands of genes using RNAi allows researchers to more readily pinpoint the genes that control a biological process. Therefore, TRC developed the high-throughput techniq...

Driver of anthrax toxicity could lead to late-stage therapy

...ve antigen carrier" of anthrax toxin, allowing its delivery into cells. The new findings "reveal a previously unsuspected biological role" for LRP6, a gene earlier found to play important roles in pathways underlying early development and cell proliferation, the researchers said. The discovery also suggests ...

Chemotherapy gel may fight breast cancer and reduce breast deformity

...ers found that they could successfully control the delivery of chemotherapy over a period of 30 days and that the tumors were completely eradicated compared to a control group of mice that were implanted with the gel insert without chemotherapy. "Through further research and testing, our goal is to develop t...

Virginia Tech scientists develop process for creating biocompatible fibers

...chers at Virginia Tech to develop a patch for drug delivery for horses. "We have not yet tested the specific biocompatibility (cytotoxicity) of our fibers, but we have not changed the chemical structure of the phospholipids." ...

New University of Toronto research a 'pore' excuse for engineering

...d lead to developments in microelectronics or drug delivery systems." Conventionally, computer chip manufacturers have insulated their wire connections with silica glass, preventing them from coming into contact and interfering, with each other. But the PMO film described in this study acts as a better insul...

Potential vaccine developed for deadly leishmaniasis disease

...vion Inc., a biotech company focusing on virosomal delivery systems. The group reported their findings in ACS...blems. Seeberger’s candidate vaccine combines the delivery vehicle, immune-stimulating antigen and adjuvant into one package. The delivery vehicle is an influ...

New hybrid virus provides targeted molecular imaging of cancer

...phage or AAVP, can serve as a vehicle for targeted delivery of genes to experimental tumors in mice and to the tumors' blood vessel supply, providing a strategy for finding tumors and genetically marking them for imaging on a clinic-ready body scanner. The AAVP hybrid combines the ability of the bacterial vi...

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