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Tag: "delivery" at biology news

Scientists use gene transfer technology and common virus to block neuropathic pain

...soon. "We use the vector to provide targeted gene delivery to the nervous system," says David J. Fink, M.D., ...al cell's nucleus, which makes it the perfect gene delivery vehicle for use in the nervous system. "When we inject our HSV gene carrier under the skin of a lab...

Bone marrow stem cells may heal hearts even years after heart attacks

... present study is that it shows that intracoronary delivery of bone marrow cells improves function and flow in patients with old myocardial infarction. This widens dramatically the applicability of stem cell therapies," Dr. Bolli said. "I believe that clinical applicability of stem cells will become a reality...

Minimally Invasive Cancer Treatments Highlighted

...ut harming the healthy cells in the body. Targeted delivery of gene- and immuno-therapies are new frontiers in cancer treatment under investigation by interventional radiologists in collaboration with other specialists. Interventional radiologists are uniquely skilled in using imaging guidance to deliver targ...

Smoking damages key regulatory enzyme in the lung

...acer chemical much longer than nonsmokers, and the delivery of tracer into the arterial blood supply was much lower for smokers, particularly for the first few minutes after being injected, Fowler added. This finding could imply that smokers and nonsmokers respond differently to other substances that enter th...

HIV inserts into human genome using a DNA-associated protein

...c sequences into human chromosomes, such as in the delivery of Factor VIII for hemophilia patients. HIV inte...les insert in the human genome could help make the delivery of new therapeutic sequences safer. The new findings about LEDGF suggest that engineered tethering i...

Chernobyl: The true scale of the accident

...number of stillbirths, adverse pregnancy outcomes, delivery complications or overall health of children. A modest but steady increase in reported congenital malformations in both contaminated and uncontaminated areas of Belarus appears related to better reporting, not radiation. Did the trauma of rapid reloc...

Plant wounds trigger bacteria

... findings could be exploited to get more effective delivery of DNA for biotechnology uses." He is the senior author of a paper published in a recent issue of the Proceedings of the National Academies of Science (PNAS, Vol. 102, No. 41). "Many other disease-causing bacteria are like Agrobacterium , in th...

University of Delaware researchers develop cancer 'nanobomb'

...looking at the use of the carbon nanotubes as drug delivery vehicles. Because they are smaller than the size of a single cell, the nanotubes can provide for the highly selective injection of drugs into individual cells. As they undertook various experiments, however, the team made a startling discovery. "W...

Plant gene related to cancer treatment may foster new oncology drugs

...d ATP-binding cassette (ABC) proteins, that act as delivery trucks to detoxify cells, send messages from cell ...s to function primarily as an aide rather than the delivery truck for auxin transport, Murphy said. This finding revealed that PINs and PGPs may function togeth...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...ice University study aims to improve the method of delivery of nanoshells to a tumor. Although the leaky blood...es is going into the clinic as a prototype of gene delivery strategy for this technology," she notes. "It's a platform technology." A phase I study of the strat...

Tsunami + 1 year: Reviving exhausted fisheries should trump replacing boats, gear, experts say

...Fish Director-General Stephen Hall says that while delivery of aid has varied significantly from one location to another across the tsunami-affected region, infrastructure replacement is relatively easy to achieve compared with reformulating fisheries policy and modifying long-standing practices of communitie...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

..."This is the first study to demonstrate successful delivery of a gene vector from a bare metal surface," said senior author Robert J. Levy, M.D., the William J. Rashkind Chair of Pediatric Cardiology at The Children's Hospital of Philadelphia. A gene vector is a biological substance, in this case an adenoviru...

A New Era of Hope for the World's Most Neglected Diseases

...iquantel, azithromycin, and ivermectin—in a single delivery mechanism in order to simultaneously target lymphatic filariasis, onchocerciasis, soil-transmitted helminthiases, schistosomiasis, and trachoma (Lancet 365: 1029?030). Thirdly, and perhaps most importantly, the neglected diseases have at long last c...

Is it Possible to Change Prescribing Habits?

...ithin a large public-health-integrated health-care delivery system, and results may be different in other settings such as hospitals and private physician offices. However, changing prescriber practice at all is not easy to achieve and this approach thus warrants further research. ...

Cord blood cells may widen treatment window for stroke

...after the brain attack, which was when intravenous delivery of the cells appeared most beneficial. "We were very surprised," said principal investigator Alison Willing, PhD, a neuroscientist at the USF Center of Excellence for Aging and Brain Repair. "In some animals, the stroke initially damaged half the br...

Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

...ral building blocks -- that effectively blocks the delivery of most drugs from the bloodstream. But now scien...his work shows that stem cells can be used as drug delivery vehicles in the brain," says Svendsen, a professor of anatomy whose laboratory is at the UW-Madison ...

Bacteria that cause tooth decay able to survive without important biochemical pathway

...in biochemical pathway involved in the folding and delivery of proteins to cell membranes is essential for sur...2, might be acting as alternate routes for protein delivery in the absence of the SRP pathway. They tested their hypothesis and found that S. mutans could conti...

HIV-infected adults in Botswana respond positively to ARV therapy public treatment program

...the developed world. A fully supported health care delivery system and infrastructure help ensure this success, according to data published in November 2005 issue of the Journal of Acquired Immune Deficiency Syndromes (JAIDS). More than 95 percent of HIV-infected people live in resource-poor nations -- and o...

New Therapeutic Target Identified In Inherited Brain Tumor Disorder

...the developed world. A fully supported health care delivery system and infrastructure help ensure this success, according to data published in November 2005 issue of the Journal of Acquired Immune Deficiency Syndromes (JAIDS). More than 95 percent of HIV-infected people live in resource-poor nations -- and o...

Largest computational biology simulation mimics life’s most essential nanomachine

...the developed world. A fully supported health care delivery system and infrastructure help ensure this success, according to data published in November 2005 issue of the Journal of Acquired Immune Deficiency Syndromes (JAIDS). More than 95 percent of HIV-infected people live in resource-poor nations -- and o...

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