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Tag: "delivery" at biology news

Unusual antibiotics show promise against deadly 'superbugs'

...tion, collagen is commonly used in cosmetics, drug delivery systems and biocompatible coatings. Yu's goal is to change some of collagen's biochemical or mechanical properties to give it new medical applications. Traditionally, scientists have altered collagen by using intense heat or chemical reactions, tec...

Motor transport in bio-nano systems

...ing devices for biomolecules and biocolloids, drug delivery systems that utilize the motor transport within human cells, and motile components for nanoscale manufacturing. Long term, we should also be able to construct 'smart' biomimetic systems which are able to respond to and 'survive' in a changing environ...

Self-assembled DNA buckyballs for drug delivery

... tiny geodesic spheres that could be used for drug delivery and as containers for chemical reactions. The term "buckyballs" has been used up to now for tiny spherical assemblies of carbon atoms known as Buckminsterfullerenes or just fullerenes. Under the right conditions, carbon atoms can link up into hexag...

Virginia Tech group adds tools to DNA-targeted anti-cancer drugs

...es facing photodynamic therapy, or activating drug delivery devices with light. The Brewer group's systems could be activated by visible light in the therapeutic range - a wavelength not blocked or reflected by tissue. The systems also were able to operate without oxygen. The group now has more kinds of supr...

Bad aftertaste? New sensory on/off switch may 'cure' bane of artificial sweetener search

...es facing photodynamic therapy, or activating drug delivery devices with light. The Brewer group's systems could be activated by visible light in the therapeutic range - a wavelength not blocked or reflected by tissue. The systems also were able to operate without oxygen. The group now has more kinds of supr...

New defibrillator signals doctor of patient's irregular heartbeat or device malfunction

...ed patients. "The new ICD provides faster delivery of care to patients and also reduces the number of times a patient has to go to the doctor's office for follow-up visits," said Varma, who specializes in treatment of arrhythmias. Because patients' heart muscle pumping action can be poor as a result...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...olecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects. Anupam Agarwal, M.D., director of the UAB Nephrology Research and Training Center and senior author of the report, said the group found that IL-10 was active through the heme oxygena...

New research could help us deliver genes for new bone formation

...lds to act as a coating around the nanoscopic gene delivery systems. The scaffold controls the release of the gene delivery systems to generate the prolonged formation and development of bone tissue. The research teams are ...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...nnitol. After the 100-minute infusion period, the delivery catheter was withdrawn and the incision closed. No hardware was left behind following this procedure, and all patients were discharged within 48 hours of the procedure. About Neurologix Neurologix, Inc. is a development-stage company, which thro...

Nose odors and mouth odors: The brain distinguishes

...t to a far lesser extent. "The effect of route of delivery was greatest for the chocolate odor, raising the possibility that odorant administration interacts with experience to engage unique brain regions and that olfactory referral induced by retronasal stimulation creates a differential reward context for ...

US Army plans to bulk-buy anthrax

...can definitely see them testing biological weapons delivery systems for threat assessment," says Hammond. Whatever use it is put to, however, the move could be seen as highly provocative by other nations, he says. "What would happen to the Biological Weapons Convention if other countries followed suit and bu...

Hopkins scientists uncover 'tags' that force proteins to cell surface

...losest relatives actually mark normal proteins for delivery to the cell surface," says Li. "In some diseases, ...ut what tiny sequences might label the protein for delivery to the cell surface, Shikano added randomly generated eight-building-block long tags onto one end of...

Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development

...s' merger with the cell membrane and the microbe's delivery of its genetic contents into the cell, when the fate of the host cell still hangs in the balance. This intermediate stage, which can last several minutes, may represent a window of opportunity for drug development. The remarkable findings, captured ...

Can two killers make a cure?

...hs, a far better proportion than achieved by other delivery methods (New Scientist, 10 March 2001, p 19). But will it work in humans? The team has now done the next best thing and used the hybrid virus to deliver a test gene, lacZ, to the lungs of monkeys. After two months the gene was active in 21 per cent ...

Digging in the dirt for life's biochemical foundations

...ation molecule towards the plant. Then just before delivery to the plant cell, it unhitches the carbon and releases only the nitrogen to the plant." The researchers demonstrated the results in a highly controlled laboratory environment, so "the big challenge now will be to see whether the same mechanism is i...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...use models. The AAV-1 vector was given by systemic delivery ?a single infusion into the abdominal cavity ?a method the authors only recently described and which they used for the first time in this study to transfer a therapeutic gene. The AAV-2 vector was delivered locally, given by intramuscular injection t...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...ulation of anti-inflammatory genes, as well as the delivery and release at the site of injury of organ-protect...istered stem cells is such that it facilitates the delivery of renoprotective growth factors and cytokines to the sites where kidney cells are primarily destroy...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...soon. “We use the vector to provide targeted gene delivery to the nervous system,?says David J. Fink, M.D., t...al cell's nucleus, which makes it the perfect gene delivery vehicle for use in the nervous system. “When we inject our HSV gene carrier under the skin of a lab...

'Cookbook recipes' would cure disease with nontoxic DNA delivery systems

...e created a "cookbook" for a class of nontoxic DNA delivery systems that will assist doctors and clinicians in the safe and effective delivery of genetic medicine. As reported in the Aug. 9 issue of the Proceedings of the National Academy of ...

Vaccine targets tumors where they live

...this vaccine is safe and feasible to use for local delivery into established melanoma lesions. 2 of the injected lesions showed a partial response and 3 were stable. One patient remained alive without disease recurrence for 59 months after vaccination without any other therapy. This approach may be useful for...

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