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Tag: "delivery" at biology news

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...n of the gene to motor neuron cells using a single delivery mechanism. "This is the first proof of principle i...ng. Both these effects are expressed long-term via delivery by a single lentiviral vector. Aebischer is optimistic about the future of gene silencing as a pote...

Scientists identify genetic pathways essential to RNA interference

...tners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups, and nonacute and home health services. ...

New Estimates For The Causes Of Child Deaths Worldwide

... (8%), neonatal sepsis or pneumonia (10%), preterm delivery (10%), and asphyxia at birth (8%). Robert Black (Johns Hopkins Bloomberg School of Public Health, Baltimore, USA) and colleagues in an independent group on child health epidemiology, along with those from the World Health Organisation (WHO), analyse...

Used in a new way, RNA interference permanently silences key breast cancer gene

...f the cancer cell. After a single exposure of this delivery system, they found 75 percent of laboratory breast... findings is not on the horizon because lentivirus delivery systems haven't been approved for human use yet, and because of the many problems associated with tr...

Nanoparticle Breast Cancer Drug Approved by FDA

...ased effectiveness may also be due to preferential delivery of albumin-bound paclitaxel to cancer cells. Abraxane was developed by American Bioscience and will be marketed by Abraxis Oncology, a division of American Pharmaceutical Partners. ...

Turning viruses into allies against cancer

... help scientists evaluate the efficacy and optimal delivery system of their radio-virotherapy vector. "We expect this work will take another two years before this technology will be available for testing in patient studies," said Blechacz. ...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

A novel delivery system that transports gene silencing nanoparticle... lead investigators. "We conclude that this novel delivery system is a powerful and simple method to induce gene silencing, with the potential to move to clini...

UCLA scientists store materials in cells natural vaults

...r cell without harming healthy tissue * Enzyme delivery to replace missing or defective enzymes, such as those that cause Tay Sachs disease * DNA delivery to correct genetic mutations * Timed release of drugs, enzymes and DNA * Extracting and impr...

Research shows smoking adds a decade to reproductive age of IVF patients

...ear of age. "In all subgroups smokers had a lower delivery rate per treatment cycle than non-smokers," Dr Lintsen said. "The live birth rate for smokers was 28% lower than that of non-smokers. This was most marked in women who had no known cause for subfertility where the live birth rate among smokers was on...

Researchers pioneer new gene therapy technique using natural repair process

...uccessful because of technical difficulties in the delivery method. In one instance, the correct IL-2R gene was delivered to mutant cells of SCID children by a disabled virus, but some subsequently developed leukemia because the virus inadvertently turned on a cancer gene. Dr. Porteus' strategy differs funda...

15 generations of untrained jocks, couch potatoes show big physiological adaptations

...e genetic role in endurance performance and oxygen delivery systems. Results of this large longitudinal study...the G7 stage, the researchers pointed out. Oxygen delivery system maximized over time; support for 'controversial thesis' Overall, Kirkton said the G15 result...

$5.1 billion would save 6 million children

... donors. The biggest challenges are increasing the delivery of health services and the lack of readily availab...ge levels from 2000 for drugs and other materials, delivery of treatment, program management and support were calculated to obtain the average cost to save a ch...

MIT engineers an anti-cancer smart bomb

...emic toxicity much better than other treatment and delivery variations. But it is patient survival and quality of life that really inspire this research, Sasisekharan said. Eighty percent of the nanocell mice survived beyond 65 days, while mice treated with the best current therapy survived 30 days. Untreate...

Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs

...-free injections or through inhalation. But, these delivery methods pose their own significant challenges. Ultimately, Shen and colleagues began to reconsider the possibilities of oral drug administration. Their first breakthrough came when they began to recognize the potential uses of transferrin. "We disco...

New method shows it is possible to grow bone for grafts within a patient's body

...commercially available and approved by the FDA for delivery of cells within the human body. They chose the material because it contained calcium, a known trigger for bone growth. Their major concern was that the bioreactor would fill with scar tissue instead of bone, but that didn't happen. Instead, it filled...

One hit of crystal meth causes birth defects

... pregnant mice only once to methamphetamine led to delivery of offspring with long-term neurodevelopmental problems, including reduced motor co-ordination. Methamphetamine is a potent and addictive stimulant. "We've known for a while that meth abuse during pregnancy is associated with low birth weight, cleft...

Researchers extend mouse lifespan by protecting against free radicals

... that breaks down hydrogen peroxide. They targeted delivery of the catalase to different areas of the cell: the cytoplasm, where catalase normally goes to decompose hydrogen peroxide; the nucleus, the DNA-containing "control center" for the cell; and the mitochondrion, the cell's power plant that converts org...

Researchers find first evidence of venom system in extinct mammal

...e first evidence of an extinct mammal with a venom delivery apparatus. The research will be published June 23,... been much more flexible in the evolution of venom delivery systems than previously believed," said Fox, who works out of the Laboratory for Vertebrate Paleonto...

When it comes to cell entry, being average has its advantages

...mation is significant for developing gene and drug delivery tools as well as assessing the safety of nanotubes ?infinitesimal bits of carbon and other materials used in everything from cameras to clothing. "If you know how viruses get into cells, you know how to better design drugs to keep them out," said L....

Modified collagen could yield important medical applications

...tion, collagen is commonly used in cosmetics, drug delivery systems and biocompatible coatings. Yu's goal is to change some of collagen's biochemical or mechanical properties to give it new medical applications. Traditionally, scientists have altered collagen by using intense heat or chemical reactions, tec...

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