Researchers create infectious hepatitis C virus in a test tube
...k that in humans the virus enters a liver cell and delivers its RNA and proteins into the cell cytoplasm. HCV carries its genetic information in its RNA, which is separated from the protein, copied, and then joined with new protein components before being released from the liver cell to infect other cells. L...Gene therapy advance treats hemophilia in mouse models
...ge of Medicine improved a vector -- a vehicle that delivers gene therapy to cells -- in two ways to create a sustained, partial correction to bleeding problems in mice engineered to have Hemophilia A, which is also known as factor VIII deficiency. The findings appear in the Sept. 1 issue of the journal Blood...Researchers test new therapy for advanced melanoma
...ue in which a hand-held device applied to the skin delivers pulses of electricity to open up pores in the tumor cell membrane. This opening allows a small therapeutic molecule -- in this case a molecule known as a DNA plasmid that contains the gene for Interleukin-12 -- to slip inside the melanoma tumor befor...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
...proach, a protein called transferrin that normally delivers iron into cells is modified to also smuggle into tumor cells siRNA (short interfering RNA) encased in nano-sized sugar polymers. The siRNA was designed to target a specific growth-promoting gene called EWS-FLI1 that's active only in Ewing's sarcoma t......s. When applied to the skin, this patch technology delivers fentanyl, an opioid pain medication that is slowly absorbed into the body through the skin providing pain relief for up to three days (72 hours). The agency's approval is expected to provide patients with access to a lower cost alternative of this p...FDA Clears the Way for Generic Versions of Transdermal Patches to Treat Chronic Pain
...s. When applied to the skin, this patch technology delivers fentanyl, an opioid pain medication that is slowly absorbed into the body through the skin providing pain relief for up to three days (72 hours). The agency's approval is expected to provide patients with access to a lower cost alternative of this p......r chamber that holds fluid, or medium. This medium delivers chemical messengers, called cytokines, to the stem cells. The cytokines essentially tell the stem cells to stay in their undifferentiated state. The difference between growing stem cells in a flask vs. the bioreactor is that the cells grown in the b...