Tag: "delivered" at biology news

Enzyme delivered in smaller package protects cells from radiation damage

...logy, University of Pittsburgh School of Medicine, delivered the human MnSOD enzyme into mouse hematopoietic progenitor cells using a newly constructed gene therapy vector called a "minicircle" plasmid. To determine if the cells transfected with the MnSOD minicircle plasmid retained radioprotective capacity...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

.... Fluorescent protein studies also showed that the delivered genes had been effectively incorporated into the target nerve cells. According to Dr. Glorioso, HSV delivery of GDNF or neurturin presents a potentially important new approach for the treatment of ED. "Because the herpes virus persists in the nerv...

Undergraduate research shows leaderless honeybee organizing

...or is programmed, with changes dictated by signals delivered by older workers. This does not mean, however, that the colony is controlled by a key group of experienced bees either. The worker bees that deliver the critical signals have short life-spans and tiny brains incapable of managing the colony the wa...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

...nse to drug therapy. The carbon nanotubes could be delivered into diseased cells and then exposed to light, causing them to heat up and kill only those diseased cells, Akin said....

Blood-brain barrier breached by new therapeutic strategy

...e blood-brain barrier, which prevents systemically delivered therapeutic drugs from reaching the brain. Grantee...nto the brain via intravenous administration. Once delivered to the nerve cells of the brain, the strip, called a small interfering RNA (siRNA), was shown to pro...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

...h, to see whether the same therapeutic gene can be delivered instead by an adeno-associated vector (AAV). AAVs have already been approved as safe for experimental gene therapy by the U.S. Food and Drug Administration, eliminating a tremendous regulatory hurdle. If successful, this next study will provide the p...

Ants show us how to make super-highways

...nest, making a flatter surface so that prey can be delivered to the developing young at maximum speed. The rai...c and results in an increase in the amount of prey delivered to the nest each day. Professor Franks said: "I think every road user who has ever inwardly curse...

Treating HIV in war zones -- Public health emergencies need rapid advice from WHO

HIV treatment can be delivered even in settings of armed conflict, and humanitarian health agencies should not wait until a conflict is over before launching HIV care programs, say a team from Médecins Sans Frontières (MSF) in this week’s PLoS Medicine. Heather Culbert and collea...

Avian influenza survivors' antibodies effective at neutralising H5N1 strain

...tnam. "We are optimistic that these antibodies, if delivered at the right time and at the right amount, could also provide a clinical benefit to humans with H5N1 infections." "In particular, we found that it was possible to administer the treatment up to 72 hours after infection. This is particularly import...

How brain pacemakers erase diseased messages

...f neurons in action also revealed that stimulation delivered at too slow a pace fails to keep bad information at bay. Indeed, slower pulses can actually add to problematic bursts, they showed. The model's findings closely parallel the clinical responses of patients, who typically experience the greatest rel...

The quest for an effective HIV vaccine presents new possibilities, challenges

...ul and is eventually licensed, it would need to be delivered as part of a comprehensive, multifaceted HIV prevention program. ...

Iowa State scientists demonstrate first use of nanotechnology to enter plant cells

... "Until now, you were at nature’s mercy when you delivered a gene into a cell," Lin said. "There’s been no precise control as to whether the cells will actually incorporate the gene and express the consequent protein. With this technology, we may be able to control the whole sequence in the future." And o...

Fused nasal bones helped tyrannosaurids dismember prey

...nimals. "With tyrannosaurs, all the bite force was delivered to the prey," he said. "The T. rex especially had a very strong skull and jaw muscles that would turn it into a zoological superweapon. A medium-sized T. rex had even more skull strength than a larger carnivorous creature, such as the Carcharadon...

Brain's reward circuit activity ebbs and flows with a woman's hormonal cycle

.... Activity patterns that emerged when rewards were delivered during the post-ovulatory phase suggested that estrogen's effect on the reward circuit might be altered by the presence of progesterone during that period. Men showed a different activation profile than women during both anticipation and delivery ...

Penn researchers show how nanocylinders deliver medicine better than nanospheres

...al model of lung cancer ten times longer than that delivered on spherical-shaped carriers. These findings have ...rculation for up to one week after injection, they delivered a more effective dose, killing more cancer cells and shrinking the tumors to a much greater extent. ...

'Guardian of the genome' protein found to underlie skin tanning

...inocytes, POMC levels rose dramatically. When they delivered UV radiation to mice whose keratinocytes lacked p53, POMC production was not induced and the mice did not tan. The implications of the research go beyond tanning. A common skin condition, especially among the elderly, is the development of small, ...

Breakthrough vaccine to treat chemo-resistant ovarian cancer

...specific vaccine and is combined with chemotherapy delivered directly into the abdominal cavity. Ovarian cancer, one of the hardest cancers to detect in the early stages, is a very complex disease that is often resistant to chemotherapy. Cancer Treatment Centers of America will offer this new treatment to...

Synthetic peptide targets latent papilloma virus infections

...somes so as not be left behind, and are copied and delivered along with the duplicate chromosomes into the daughter cells, where they again take up residence in the nucleus as latent viral DNA. The viral plasmids turn into infectious viruses only in the top, differentiated layers of tissue. Previous work sho...

Research finds music training 'tunes' human auditory system

...alled "tones." For example, the Mandarin word "mi" delivered in a level tone means "to squint," in a rising tone means "to bewilder," and in a dipping (falling then rising) tone means "rice." English, on the other hand, only uses pitch to reflect intonation (as when rising pitch is used in questions). As...

Cancer-killing invention also harvests stem cells

... targets cancer cells. The apoptosis signal is delivered by a molecule called TRAIL that coats the cancer-killing device. Cancer cells have five types of proteins that recognize and bind to TRAIL, but only two trigger cell death. The other three are called decoy receptors. Healthy cells contain a lot of...

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