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Tag: "deliver" at biology news

New push for public health, AIDS spending at African Union summit

... development issue," she said. "Now they have to deliver on the existing protocols and develop a serious and practical strategy." Mozambique is the only country that has, thus far, committed to allocating 15 per cent of its gross domestic product to healthcare in the four years since the goal was stated d...

Priming embryonic stem cells to fulfill their promise

...nique ability of so-called DNA spottingmachines to deliver tiny volumes of liquid, about one trillionth of aliter per spot. The spotting machines, which cost as little as $20,000,have become common fixtures at most research universities, but theinnovation reported today in Nature Methods involved using such ...

Researchers Uncover Key Step In Manufacture of Memory Protein

... the enzyme carboxypeptidase E, (CPE) is needed to deliver the early, or inactive, form of BDNF ?proBDNF ?to a special compartment in the neuron (nerve cell.) Once in the compartment, proBDNF is chemically converted into active mBDNF. After mBDNF is formed, it is released to the outside of the neuron, where ...

Learning to fight an adversary that won't stay down

...w biomolecular technologies have largely failed to deliver the hoped-for knockout punch breakthrough against the defences of disease-causing bacteria, says a leading Canadian specialist in antibiotic resistance. Techniques such as genomic sequencing and high throughput screening were expected to make the de...

Taking Aim With Nanoparticle PEBBLEs

...ance their visibility on MRI images, and others to deliver a deadly cargo to cancer cells when triggered by e...nother advantage: the "killer oxygen" that PEBBLEs deliver to cancer cells is too unstable to wander off and damage healthy cells, so only targeted cells are a...

Probing The Promise And Perils Of Nanoparticles

...called polycationic polymers—already being used to deliver drugs and genes—to see if they behaved like dendrimers. "It turns out that they cause the same permeability and, in general, they cause membrane destruction as well," said Banaszak Holl. Neutral polymers, however, did not damage membranes. Both Lero...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...rapy used in monkeys represents a different way to deliver the GDNF to the brain, causing the body to produce it naturally. It also produces more manageable levels of the protein in the brain. “Our strategy is a neuroprotective concept and would only be amenable for early stage patients to keep a good quali...

Boosting HIV screening can increase survival and is cost effective

... U.S. general population, one-time screening could deliver excellent return on investment. "HIV is a severe disease that, left untreated, produces substantial morbidity and mortality," said Paltiel. "It has a long asymptomatic phase, which can be diagnosed using very effective, inexpensive tests. Most impor...

UF Researchers Map Bacterial Proteins That Cause Tooth Loss

...periodontal disease are seven times more likely to deliver low-birth-weight, preterm babies. Proteins are important to study because they are the foundation of the cellular structure of every living organism, Lamont said. They carry on the day-to-day biology of life, going about their business as enzymes and...

Gene therapy for Parkinson's disease moves forward in animals

...rapy used in monkeys represents a different way to deliver the GDNF to the brain, causing the body to produce it naturally. It also produces more manageable levels of the protein in the brain. "Our strategy is a neuroprotective concept and would only be amenable for early stage patients to keep a good quali...

Applied Biosystems Introduces Advanced Gene Expression Service Provider Program

...detection instrument, software, and chemistries to deliver unambiguous gene results that are highly sensitive and reproducible. The PCR process and the 5' nuclease detection process are covered by patents owned by Roche Molecular System, Inc. and F. Hoffmann-La Roche Ltd ("Roche"). Performing services using...

Harnessing microbes, one by one, to build a better nanoworld

...detection instrument, software, and chemistries to deliver unambiguous gene results that are highly sensitive and reproducible. The PCR process and the 5' nuclease detection process are covered by patents owned by Roche Molecular System, Inc. and F. Hoffmann-La Roche Ltd ("Roche"). Performing services using...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

...novate Life Sciences, this new product promises to deliver significantly improved technical and economic outc...nalytical resources to ensure that NittoPhase?will deliver unmatched performance.?/p> “Our internal testing and analysis of NittoPhase?has clearly validate...

PET/MRI scans may help unravel mechanisms of prenatal drug damage

...he animals were returned to their social colony to deliver their offspring. The combined images show that cocaine and/or its labeled metabolites readily cross the placenta. But the cocaine uptake distribution pattern observed in the fetus was very different from that of the mother. For example, mothers show...

Probing the promise and perils of nanoparticles

...lled polycationic polymers---already being used to deliver drugs and genes---to see if they behaved like dendrimers. "It turns out that they cause the same permeability and, in general, they cause membrane destruction as well," said Banaszak Holl. Neutral polymers, however, did not damage membranes. Both Le...

Nanoparticles offer new hope for detection and treatment

... a variety of substances, they also may be able to deliver cancer-fighting drugs to malignant tumors as effec...blood vessel formation. Plus, we should be able to deliver chemotherapeutic drugs right to melanoma cells, because melanoma tumors create blood vessels using t...

Medical molecules designed to respond to visible light that can penetrate tissue

... we can't signal molecules deep within the body to deliver drug therapy," says Brewer, associate professor of chemistry. Matthew Mongelli of Maywood N.J., a postdoctoral associate in chemistry, and his colleagues in chemistry and biology at Virginia Tech, have been working with Theralase Technologies Inc. t...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

..., the EPFL researchers were able to simultaneously deliver a normal version of the gene to motor neuron cells using a single delivery mechanism. "This is the first proof of principle in the human form of a disease of the nervous system in which you can silence the gene and at the same time produce another no...

Used in a new way, RNA interference permanently silences key breast cancer gene

...rchers used a lentivirus (a type of retrovirus) to deliver a specifically designed long-acting small interfering RNA (termed a short hairpin RNA, shRNA) for mouse STAT3 into a mouse breast cancer cell line. They chose STAT3 because when activated, it is involved in the formation of multiple types of tumors, ...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

...for a variety of reasons, including the ability to deliver these bits of genetic material in high concentrations to specific tumor sites, while avoiding degradation. To overcome these hurdles, the scientists employed a sugar-containing polymer invented by chemical engineers at the California Institute of Te...

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