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Tag: "deletion" at biology news

Genome changes tracked during multiple myeloma initiation, progression and treatment

...nd tumor suppressor genes. These amplification and deletion patterns define new disease subgroups of MM that are characterized by varied dysregulation of distinct cancer-relevant genes and can be correlated with different clinical outcomes. Importantly, several candidate genes identified in this study possess...

Biomarkers may hone anti-aging therapies

...hat perhaps there was a specific mitochondrial DNA deletion signature that would be associated with tumor deve... The investigators searched for mitochondrial DNA deletion mutations in skin samples from patients having non-melanoma skin cancer removed in the Vanderbilt Mo...

Researches discover gene critical for protection against septic-shock-induced death

...hma in mice models. Biswal's team found that the deletion of the Nrf2 gene increased the inflammatory response and caused early death in mice subjected to septic peritonitis or endotoxin shock or both. Mice deficient in Nrf2 gene expressed dramatically increased levels of effector molecules (cytokines) that...

Major obesity gene is 'lost in the shuffle'

... gene was missing in gibbons. "We found that this deletion occurred between two pieces of DNA that are quite ...ene 'knockout' experiment," Ishida explains. "The deletion ?or 'knockout' ?of the ASIP gene may have helped gibbons adapt to arboreal niches. We know that t...

New human retrovirus originated in mice

...ous viral genomes have undergone such mutation and deletion that they are incapable of giving rise to viruses any more," said Ganem. "And while some of these viruses had been induced to grow in human cells in culture, the major question is whether such infection could ever happen in nature. "So, one of the t...

Cycles of cell death, proliferation key to liver cancer

...used to elicit liver cancer in mice. Importantly, deletion of the gene that codes for the major isoform of JNK in liver cells, JNK1, prevented the development of liver cancer and reversed the tumor-enhancing effect caused by ablation of IKKƒÒ. "We found that long-term JNK activation leads to cell death; if ...

Non-coding RNAs help silence the mammalian transcription

...ader-Willi and Angelman syndromes, result from the deletion of the identical portion of chromosome 15. Imprinting determines which disorder arises: When the deletion involves the chromosome 15 that came from the father, the child has Prader-Willi syndrome, but when ...

Speeding the search for elusive chromosomal errors

...ems. For example, patients with chromosome 22q11.2 deletion syndrome may have heart defects, impaired immunity and developmental delay. Deletions of several genes in Prader-Willi syndrome may cause obesity and mental retardation. To seek out miniscule rearrangements in chromosomes, the Children's Hospital te...

NYU algorithm enhances ability to detect cancer genes

...cutive probes, and the score reflects how well the deletion of that genomic interval may explain the cancer in these patients. In other words, the computed score measures how likely it is for a particular genomic interval to be a tumor suppressor gene implicated in the disease. In order to validate their algo...

Mutant mice show key autism traits

..."as appropriately pointed out by the authors, Pten deletion is restricted to postmitotic neurons in the CNS [central nervous system] in their model, and current evidence suggests that ASD is a developmental rather than a neurodegenerative disorder." Greer and Wynshaw-Boris concluded that "Whether or not the ...

'Protecting virus' offers instant flu protection and converts flu infections into their own vaccines

...protecting influenza virus has a huge but specific deletion of around 80% of the RNA of one of these 8 strands. This deletion makes the virus harmless and prevents it from reproducing by itself within a cell, so that it cannot...

Largest genomic search finds genes that may contribute to autism

...'t know what happens when there is an insertion or deletion of this genetic material," he added. Scientists believe that there may be five or six major genes and perhaps as many as 30 other genes involved in autism. Inheriting more of these genes or certain ones is thought to increase a child's likeliho...

Shedding new light on proteorhodopsin

...nipulate microbial genomes through the addition or deletion of key genes. ...

Blood sugar's manufacture limited by building blocks' supply

... The researchers found that mice with a targeted deletion of KLF15 display severe hypoglycemia after an overnight fast. They further found evidence that defective amino acid breakdown promotes the development of fasting hypoglycemia in the mutant animals by limiting the availability of a glucose substrate c...

Loss of stem cells correlates with premature aging in animal study

...ss, the 10 to 20 percent of cells that escaped ATR deletion were able to reconstitute tissues in the engineered mice, at least initially. “Think of aging as a slow loss of stem cells, a deterioration of pools of cells that reside in each tissue type,” says Brown. We accelerated the aging process by wipin...

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