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Tag: "deletion" at biology news

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

...ng of the same study, all the patients with the 5q deletion who became transfusion independent also went into cytogenetic remission, meaning that the chromosome abnormality disappeared. List, a professor of interdisciplinary oncology at the University of South Florida, initially developed the phase I clinica...

Opposing fat metabolism pathways triggered by a single gene

...at content in the larvae. They further showed that deletion of nhr-49 changed expression of 13 genes related to fat and glucose metabolism, with the most dramatic effects occurring within two metabolic pathways: mitochondrial lipid oxidation and fatty acid desaturation. Following up on these changes in gene ...

New tumor-suppressor gene discovered

...gging lots of material along with it. "With such a deletion of material, this gene is basically gone, so we knew it couldn't possibly function at all," Lai says. Both kinds of mutations resulted in the formation of the same kinds of tumors. These studies indicate that the disabling of this one gene alone can ...

Chromosome Deletion Predicts Aggressive Neuroblastoma

.... A new study suggests that detecting this genetic deletion during the initial evaluation of children with neu...are aggressive without having amplified MYCN. "The deletion of genetic material on chromosome 11 may account for a significant percentage of these high-risk neu...

Of mice and men's (and women's) contraceptives

...lled somatic cells. "There are many proteins whose deletion will cause male infertility, and others for creating female infertility, but not many that will lead to both male and female infertility without affecting the somatic cells." Animals deficient in the protein ?called MSY2 ?are infertile, but are othe...

Big differences in duplicated DNA distinguish chimp and human genomes

...ng one-third of duplication differences are due to deletion of segments in one of the two species - the segment is deleted from the genome, copy by copy, over time. The researchers found that many of the species-specific duplications have also caused differences in gene expression. Of the individual genes w...

Researchers track down cause of a disfiguring bone disorder

...e strong evidence that "the (Van Buchem) noncoding deletion removes a SOST-specific regulatory element," the team reported, indicating that the disease is caused by the absence of one or more distant enhancer elements in the deleted region that help direct the expression of the SOST gene in adult humans. In ...

Bacteria are key to 'green' plastics, drugs

... strains of E. coli and has been modified with the deletion of four genes, each of which codes for a protein that interferes with or limits E. coli's ability to turn glucose into succinate. Bennett and San activated a second pathway and stimulated production by adding genes from lactococcus bacteria and sorgh...

Studies on human genome variation provide insight into disease

...ne of every 2,000-4,000 live births and involves a deletion on chromosome 22. The deletion is mediated by rare repetitive sequences that flank genes crucial for proper development of the hear...

Housecat-sized Siberian tiger cubs get collared

...ne of every 2,000-4,000 live births and involves a deletion on chromosome 22. The deletion is mediated by rare repetitive sequences that flank genes crucial for proper development of the hear...

Customized gene chip provides rapid detection of genetic changes in children's cancer

...t abnormality is loss of heterozygosity (LOH), the deletion of one copy of a pair of genes. When the gene involved is a tumor suppressor gene, LOH removes a brake on uncontrolled cell growth, the growth that is the hallmark of cancer. Researchers in Dr. Maris' laboratory previously established that LOH in a ...

New technique multiplies life span in simple organisms

...up to six times longer than normal - when the SIR2 deletion was combined with caloric restriction and/or a mutation in one or two genes, RAS2 and SCH9, that control the storage of nutrients and resistance to cell damage. Human cells with reduced SIR2 activity also appear to confirm that SIR2 has a pro-aging ...

Genetic analysis of cavefish reveals more about evolution

...ible for pigmentation in the cavefish and that the deletion of a specific exon, or protein- coding DNA sequence, produced albinism. What remains a mystery is why the same gene should be mutated independently in all three populations when other genes are also known to cause albinism and why it should be the...

Technique offers new view of dynamic biological landscape

...t are essential for yeast growth -- whose complete deletion would kill the cell -- the researchers invented a high throughput technique to manipulate the half-life of their messenger RNA (mRNA). Since mRNA is a genetic intermediate during the conversion of a gene to protein, reducing its lifespan by mutating ...

Minimal genome should be twice the size, study shows

...u make the other essential for survival; each gene deletion reduces the available space for further reduction of the genome. "Including these alternative pathways into the minimal genome almost doubles its size." The researchers have developed a way of predicting bacterial genome content using two bacteria ...

Cancer cells suppress large regions of DNA by a reversible process that can be tackled

...ly been linked to DNA mutations of single genes or deletion of large sections of the chromosome. However more recently it has become clear that gene silencing in cancer can also occur, in the absence of changes to the DNA sequence: a phenomenon known as 'epigenetics'. DNA methylation is one of the main epigen...

Tiny RNA molecules fine-tune the brain's synapses

... He notes that loss of Limk1 due to a chromosomal deletion is associated with Williams syndrome, and that the BDNF pathway that activates Limk1 includes proteins that are disabled in tuberous sclerosis and Fragile X syndrome. All three genetic disorders can cause cognitive impairment and autistic-like behavi...

How can we protect patients with weakened immune systems from influenza?

... A third group of patients has chromosome 22q.11.2 deletion syndrome, a congenital multisystem disorder that impairs the immune system. Children's Hospital is a world leader in studying and treating this syndrome. Three projects involving adults are led by researchers in the University of Pennsylvania Health...

Therapeutic prospects beyond Vioxx

...)-1. Other investigators had shown previously that deletion of this enzyme seemed as effective as treatment wi...trials. FitzGerald and his colleagues showed that deletion of mPGES-1, in contrast to deletion or inhibition of COX-2, did not predispose the animals to thromb...

Genetic mutation linked to West Nile virus infection

...tal Medicine. The mutation in question is a small deletion in a gene that encodes a protein called CCR5, which was identified in 1996 as a co-receptor used by HIV to infect cells. Individuals with two copies of this mutation (CCR5delta32) are highly resistant to HIV infection, even when repeatedly exposed t...

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