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Tag: "degradation" at biology news

A new mechanism of regulating RNA degradation

...d be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at th...mechanism, which the team called Staufen1-mediated degradation (SMD). Preliminary results suggest that SMD activity affects numerous transcripts and, therefore, is...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...d be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at th...mechanism, which the team called Staufen1-mediated degradation (SMD). Preliminary results suggest that SMD activity affects numerous transcripts and, therefore, is...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...ondrial human pathogens. The analysis reveals the degradation of the E. histolytica genome in its transition from a free-living organism into a parasite of the human gut. At the same time, scientists also cataloged the retention and expansion of some gene families characteristic of more complex organisms. Deta...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...best knownfor its function in marking proteins for degradation by a wastedisposal unit known as a proteasome. Hayashi et al. sought to study thepossibility that ubiquitination might play a part in rendering theunbound Notch receptor inert. Their attention was drawn to Nedd4 (amember of the ubiquitin ligase famil...

Scientists collaborate to assess health of global environment

...rate than any time in history." The environmental degradation carried out to meet demand for food, fiber, timber, fresh water, fuel and other resources has begun to jeopardize more subtle services that nature has always provided free of charge, he said. Making matters worse, he added, the world's poorest people...

Essential mangrove forest threatened by cryptic ecological degradation

...that the worrying aspect of the research is that a degradation of the most vulnerable, most socio-economically im...The authors emphasize that such cryptic ecological degradation must be acknowledged by policy and decision makers if mangrove protection is an aim. The research te...

Scientists discuss improved biopesticides for locust control in West Africa

...biopesticides is low in the environment because of degradation from sunlight," Agblevor said. "We have developed coating technologies to improve on the environmental persistence of the biopesticide, specifically a lignin coating for the spores, which increases their resistance to ultraviolet radiation." Research...

Advances in the characterisation of the oyster mushroom genes

...nes involved. But nobody, to date, has tackled the degradation of cellulose from a molecular perspective. Cellul...ld seem logical that the genes responsible for the degradation of one or the other are located close together on the genome, on the same chromosomes. ...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

... rate of cholesterol production by stimulating the degradation of cholesterol-building reductase. The availabilit...avitt, and Russell A. DeBose-Boyd: "Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol" Pub...

Multi-purpose protein regulates new protein synthesis and immune cell development

... And third, it activates genes involved in protein degradation to get rid of excess unfolded proteins. So you reduce the load, get rid of garbage and increase efficiency. If these don't work, the cell will die." "Recently, scientists have discovered that the unfolded protein response is activated in many diseas...

Two are better than one

...with the right combination of antibodies, receptor degradation is accelerated: it's more than three times as effe...g HER2 signaling. "Understanding how HER receptor degradation works could enhance weak therapeutic efficacy, as well as provide ways to sensitize patients to over...

Biomarkers isolated from saliva successfully predict oral and breast cancer

...ubjects. New techniques were developed to halt RNA degradation so the scientists could recover as much mRNA as possible for their samples. In all, the new techniques allowed the scientists to harvest up to 10,000 types of human mRNA from saliva, setting up a comparison test between cancer patients and the normal...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

... these AU-rich elements built in. AU-rich element degradation involves a number of different proteins, including...inding events may play a role in the stability and degradation of the mRNA. Despite much research over the last few years into exactly how this works, the question...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

... system we're developing can shield the drugs from degradation before reaching the target sites, while delivering siRNA for more specificity and potency so as to lower the required dose for efficacy." The study was a collaborative effort between the laboratory of Timothy J. Triche, at Children's Hospital of Los...

Putting ecology back into river restoration

...rsity of Maryland: "Given the rapid rate of global degradation of fresh waters, and the fact that river and stream restoration has become a booming enterprise, it is time to agree on what constitutes successful river and stream restoration." Palmer and her colleagues say that the success of river restoration sho...

Product improves peptide identification for proteomics research

...racterization, natural products screening, product degradation studies and food and environmental analysis, which require excellent sensitivity and fast scanning capability." The LC/MSD Trap XCT Ultra, which is based on an advanced multipole ion trap technology, has a full-scan MS/MS sensitivity specification o...

Could microbes solve Russia's chemical weapons conundrum?

...ass," said Dr. Ermakova. ### Article: "Microbial degradation of the detoxification products of mustard from the Russian chemical weapons stockpile," Inna T Ermakova, Natalya S Safrina, Ivan I Starovoitov, Yelena V Lyubun, Alexander A Shcherbakov, Oleg E Makarov, Paul V Kosterin, and Alexander M Boronin, Journa...

Changing ecosystems throw scientists mega-challenges

...es are rapid shifts in climate and ecosystems, the degradation of freshwater resources, global spreading of diseases, and the increasing threat of biological and chemical terrorism. Among the research challenges are the need to understand how and why these changes are occurring—especially when multiple stresses ...

How A Latent Virus Eludes Immune Defenses

...s by inhibiting synthesis and, to a lesser degree, degradation of the protein. How this evasive action works or h...n much like EBNA-1 does, by reducing synthesis and degradation of the protein. One region strongly associated with inhibiting epitope presentation to killer T cell...

Touching Molecules With Your Bare Hands

...s by inhibiting synthesis and, to a lesser degree, degradation of the protein. How this evasive action works or h...n much like EBNA-1 does, by reducing synthesis and degradation of the protein. One region strongly associated with inhibiting epitope presentation to killer T cell...

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