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Tag: "degenerative" at biology news

Wisconsin scientists grow critical nerve cells

... injuries, or pave the way for novel treatments of degenerative diseases such as amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. With healthy cells grown in the lab, scientists could, in theory, replace dying motor neurons to restore function and alleviate the symptoms of disease or injur...

Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa

...earch component and an established patient base of degenerative retinal diseases, we were able to be a part of thi...n rehabilitative options for patients with retinal degenerative diseases, so the opportunity to be part of evaluating an experimental rehabilitative intervention fo...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...may impair learning and memory and accelerate some degenerative diseases. ...

One gene links newborn neurons with those that die in diseases such as Alzheimer's

...oratories have pointed to deficiencies in UCHL1 in degenerative diseases such as Alzheimer's and Parkinson's. Experiments in mice confirmed the finding that low levels of UCHL1 correlate to the ability of neurons to be replaced. The researchers used similar techniques to assess UCHL1 in hippocampus and olfactory...

Two chemicals boost immune cells' ability to fight HIV without gene therapy

...offer therapeutic potential for a wide spectrum of degenerative diseases and chronic conditions in which cellular aging plays a role. "I'm really excited by our findings. This progress moves us one step closer to drugs that work by switching telomerase on permanently and keeping the immune cells young and strong...

Young Blood Revives Aging Muscles, Stanford Researchers Find

... looking for likely targets. He said that for some degenerative diseases such as Alzheimer's or muscular dystrophy, such blood-borne factors may be able to reactivate the regenerative cell's ability to repair tissue that has been damaged. ### Postdoctoral scholar Michael Conboy, PhD, and former postdoctoral sch...

Mosaic mouse technique offers a powerful new tool to study diseases and genetics

...important for analysis of complex developmental or degenerative diseases resulting from genetic mutations, they added. In light of its potential commercial applications, Luo has begun the process of licensing MADM through Stanford University's Office of Technology Licensing. Meanwhile, he and his colleagues are ...

Arthritis: What Wnt wrong?

...way of a Wnt-related gene that causes severe joint degenerative disease in humans. "More specific analyses such as gain-of-function and loss-of-function study of Wnt-7b will give us a clue which Wnt-7b would be an important pathobiological factor in rheumatoid arthritis," added Nakamura. Future studies will inve...

Six previously blind patients detect light, motion, identify objects with retinal prostheses

...ople with little or no sight perception due to the degenerative eye disease retinitis pigmentosa (RP). Ultimately, however, the device is likely to be used for the millions of people suffering from age-related macular degeneration, or AMD, as well. In fact, notes Humayun, there are 25 million people across the gl...

New research could help us deliver genes for new bone formation

...provide significant healthcare benefits as trauma, degenerative disease and bone loss with old age all lead to patients needing orthopaedic procedures that require new bone. Professor Oreffo added "It is important that we explore the potential of new methods and biotechnologies to help meet the healthcare needs ...

Muscle repair: Making a good system better, faster; implications for aging, disease

...ably, and in Duchenne Muscular Dystrophy and other degenerative muscle diseases, normal repair functions can't cope with disease progression. Researchers from the University of Illinois-Chicago (UIC) and University of Michigan report that while "skeletal muscles possess a remarkable capacity for regeneration" an...

Gradient guides nerve growth down spinal cord

...ged connections in adults with traumatic injury or degenerative disorders," Zou added. The National Institute of Neurological Disorders and Stroke, the Schweppe Foundation, the Robert Packard ALS Center at Johns Hopkins, the University of Chicago Brain Research Foundation and the Jack Miller Peripheral Neuropath...

Old drug shows new promise for Huntington's Disease

...e protein kills the neurons, causing the disease's degenerative effects. In Massa's study, Clioquinol appeared to interrupt the production of mutant huntingtin.In the first part of his study, Massa and his research team tested the effect of Clioquinol on neurons in cell culture that contained a form of the mutan...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...rapy to successfully treat heart failure and other degenerative muscle problems in an animal model that is genetically susceptible to a human muscular dystrophy. Reporting in the Oct. 25 edition of the journal Circulation, the authors say that this is the first successful attempt to deliver a therapeutic gene thr...

Scientists crack code for motor neuron wiring

...cise way," Jessell continued. "And in motor neuron degenerative diseases, it may not be enough make new motor neurons; they have to connect to the right muscle target in order to restore motor function. Understanding how Hox proteins control circuit formation in the spinal cord should provide an important basic f...

Stem cells from muscles can repair cartilage

...y occurs due to injury or illness, and can lead to degenerative disease. Treatments and experimental approaches to repair this articular cartilage have achieved limited results, but currently there is no method to fully restore this type of injured cartilage. Tissue engineering involving the delivery of therapeut...

Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders

...ished online Feb. 26, 2006. Until now, theories on degenerative cell death have centered on defective proteins and/or their accumulation and aggregation in the brain. "The neurodegeneration field has been dominated by the hypothesis of misfolded proteins and their aggregation, but the identification of KCNC3 mut...

UCLA scientists find male gene in brain area targeted by Parkinson's

...ch may explain why more men than women develop the degenerative disorder, which afflicts roughly 1 million Americans. "Men are 1.5 times more likely to develop Parkinson's disease than women," said Dr. Eric Vilain, associate professor of human genetics at the David Geffen School of Medicine at UCLA. "Our finding...

U of MN researchers identify ataxia gene

...ene responsible for a type of ataxia, an incurable degenerative brain disease affecting movement and coordination. This is the first neurodegenerative disease shown to be caused by mutations in the protein â-III spectrin which plays an important role in the maintaining the health of nerve cells. The scientific d...

Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal

...r levels are controlled ?to fight off debilitating degenerative conditions that can afflict the CNS, such as Alzheimer's and Parkinson's diseases, glaucoma, amyotrophic lateral sclerosis (ALS), and the nerve degeneration that results from trauma or stroke. In their earlier research, Schwartz and her team provide...

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