Identification of specific genes predicts which patients will respond to Hepatitis C treatment
...e blood), and liver disease activity. In order to define which genes discriminate between those patients who respond to therapy to those who do not, microarray technology, based in a Banting and Best Department of Medical Research laboratory at University of Toronto, was used to analyze the pattern of gene...Scripps research scientists identify infertility molecule
... cellular membranes, those essential barriers that define the boundaries of cells and keep the molecules inside a cell separated from those outside a cell. But many phospholipids are more than just simple structural elements. Some play significant signaling roles in the cell. LPA belongs to a family of pho...Program finds lost genes in nematode genome
... the typical, less accurate methods. Being able to define intron length has implications for the human genome, which is much larger than C. elegans and has an average intron length of about 4,000 base pairs, compared with an average intron length of a couple hundred base pairs in C. elegans. Brent and coll...... attenuation over various frequency bands and they define the different sections of the tissue in the image," said Marmarelis. The two arrays, transmitter and receiver, are mounted on opposite sides of a drum that spins as it rises around the object (which is suspended in water), creating a stack of tomogr...Conserved amino acids play both structural and mechanistic roles in sandwich-like protein
...own that these eight amino acids were important to define the sandwich-like structure, but the exact role was unknown. "Why are these eight amino acids invariant across all sandwich-like proteins?" asked principal investigator Pernilla Wittung-Stafshede, associate professor of biochemistry and cell biology...Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska
...ic and others in the Southern Hemisphere. To help define areas and ecological parameters critical to the survival of this remnant population of right whales, habitat use was investigated by scientists at the NOAA National Marine Fisheries Service's, National Marine Mammal Laboratory, in Seattle, Washington...Genetic defects give the immune system the green light to attack the pancreas
...se genes are identified, we will be better able to define the biologic pathways that lead to type 1 diabetes,?said Dr. Yamagata. “We then can work on designing ways to subdue or stop this process.?/p> This study was supported by the Juvenile Diabetes Research Foundation (JDRF), in the context of the JDR...Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
...e Penn researchers, brightly emissive polymersomes define the first nanotech optical imaging platform based on non-aggregating "soft matter" (polymers and porphyrins) and hence have enormous potential in biomedicine. ...Scientists decipher genome of fungus that can cause life-threatening infections
...oundation for a broader genomeproject that aims to define the molecular basis for the C. neoformansspecies cluster, which includes three related yet diverged specieswhich differ in virulence attributes, environmental distribution andwhich have been diverging over millions of years of evolution....NYU researchers simulate molecular biological clock
...tions.The team developed a computational method to define the relationshipbetween microRNAs and their target genes. In December 2003, the samegroup identified 400 genes in the human genome targeted by microRNAs.(Prior to this study, there were no known microRNA targets in anyvertebrate.)In their latest pape...Study finds more than one-third of human genome regulated by RNA
...tions.The team developed a computational method to define the relationshipbetween microRNAs and their target genes. In December 2003, the samegroup identified 400 genes in the human genome targeted by microRNAs.(Prior to this study, there were no known microRNA targets in anyvertebrate.)In their latest pape...Male circumcision reduces risk of HIV transmission from women to men
...s is spreading rapidly in parts of Africa, andhelp define better HIV strategies for prevention in these settings.......cal features of 4E10 recognition of HIV-1 helps to define potential immunogens able to elicit 4E10-like antibodies. This is an excellent example of the tremendous potential for accelerating HIV vaccine design when scientists from multidisciplinary laboratories come together to tackle a major scientific chal...