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Tag: "deficient" at biology news

Scientists find that protein controls aging by controlling insulin

...he resistance. The opposite was true with the mice deficient in Klotho. They were more sensitive to insulin and had reduced levels of it. The influence on insulin creates a problem for Klotho should it be used as a therapy against aging: It may extend life, but it could also make an animal diabetic. Mice w...

Attacks of King George III's madness linked to key metabolism molecule

...s eight different enzymes, and when any of them is deficient because of a mutation, the process is blocked. The resulting back up of "precursor" substances is toxic, and can cause a range of symptoms, including dark colored urine, abdominal pain, nausea, vomiting, constipation, weakness in the limbs, and psych...

Specialized immune-system B cells play double-barreled role

... strains -- one that overproduced and one that was deficient in a protein called CD19 that is a key regulator of B-1a cell function and development. Thus, the two mouse strains enabled the researchers to explore the consequences of too many or too few B-1a cells. Also, the strain lacking CD19, and therefore B-...

Study finds adult stem cells can replicate

...go, Pham's lab published results showing that mice deficient in cathepsin G and other closely related proteases failed to develop arthritis after the injections. This led them to look for the mechanisms by which these proteases regulate inflammation. Observations made by Pham's lab and other groups had linked...

Enzyme's newly discovered role may make it target for arthritis treatment

...go, Pham's lab published results showing that mice deficient in cathepsin G and other closely related proteases failed to develop arthritis after the injections. This led them to look for the mechanisms by which these proteases regulate inflammation. Observations made by Pham's lab and other groups had linked...

Natural Killers Could Lead to New Hepatitis Treatments

...searchers found that the mice genetically rendered deficient in CXCR6 showed reduced survival of their NKT cells, but no change in the speed or pattern of their patrolling. The studies showed that the presence of CXCR6 prolonged the NKT cells' survival. The researchers also found that the NKT cells of CXCR6-de...

Touching Molecules With Your Bare Hands

...of the viruses can maintain latent infections with deficient episome maintenance proteins. Stevenson and colleagues first demonstrated that ORF73 limits T cell recognition and then identified a key region responsible for immune evasion by modifying different regions of the viral protein. In the next round of ...

How A Latent Virus Eludes Immune Defenses

...of the viruses can maintain latent infections with deficient episome maintenance proteins. Stevenson and colleagues first demonstrated that ORF73 limits T cell recognition and then identified a key region responsible for immune evasion by modifying different regions of the viral protein. In the next round of ...

Master gene controls healing of skin in fruit flies and mammals

...much more permeable skin than normal mice and have deficient wound repair. Both groups point out in their papers that it is interesting that the regulatory mechanisms for development and repair of the surface barrier in insects and mammals have been conserved, given the differences in the molecular composition...

Of mice and men's (and women's) contraceptives

...ity without affecting the somatic cells." Animals deficient in the protein ?called MSY2 ?are infertile, but are otherwise healthy and completely normal. Male mice produce no functional sperm, and females show early loss of eggs and defects in ovulation. The MSY2 protein is part of a family of proteins, calle...

Protein prevents detrimental immune effects of bacterial sepsis

...rom the blood into affected tissues. However, mice deficient for annexin 1 exhibited a dramatic release of whit...n, and of organ injury, were measured in annexin 1 deficient animals. Altogether, these findings implied that the protective effects of the annexin 1 pathway wer...

Multi-purpose protein regulates new protein synthesis and immune cell development

...n destroyed by radiation. He found that stem cells deficient in IRE1 could reconstitute all types of blood and immune cells in the transplanted mice, but their mature B lymphocytes were defective. Without IRE1, lymphocytes don't develop a B cell receptor and don't have the right rearrangements of immunoglobuli...

Iron exporter revealed that may explain common human disorder

...ilure of iron transfer from mother to embryo. Mice deficient for ferroportin in all tissues except those critical for maternal nutrient transfer survived but quickly became anemic after birth due to iron deficiency in the blood. Examination of the animals' intestine, liver, and spleen revealed an accumulation ...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...orted, the membranes of sickle red blood cells are deficient for the form of nitric oxide normally released by the cells. The blood cells therefore fail to open blood vessels normally. Red cells taken from patients with mild sickle cell disease dilate blood vessels under low oxygen conditions, but to a lesser...

Substance protects resilient staph bacteria

...ters to demonstrate that the S. epidermidis strain deficient of PGA was not able to cause infection while the other strains containing PGA did. ...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...d the mesenchyme. They had seen that mice that are deficient for the Foxl1 protein show a similar accumulation ...es. The group compared animals that were partially deficient for APC (containing one normal copy of the APC gene and one mutant inactive copy) in the presence or...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...veloped a strain of dwarf rats that were naturally deficient in both growth hormone and in IGF-1. To mimic the ...1 during adolescence in normal rats, some of these deficient rats were given growth hormone while they were between 4 and 14 weeks of age ?rat adolescence. Then ...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...ighest. "[T]hese data support the hypothesis that deficient DNA repair capacity is associated with susceptibility to breast cancer and may be a valuable in vitro biomarker to identify high-risk subjects, especially in familial breast cancer families," the authors write. "It is unclear at this time whether the...

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