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Tag: "deficient" at biology news

Study identifies new role for breast cancer susceptibility gene

...her studies demonstrated that mouse mammary tumors deficient in BRCA1 display high levels of ANG1 expression, prominent vascularization, and accelerated growth. "Our study finds that BRCA1 possesses a role in tumor suppression beyond maintaining genomic stability by regulating intercellular signaling within...

Gene first linked to rare disease may trigger skin cancer, other tumors

... the cell's components are suspended. "In animals deficient for CYLD, much too much Bcl-3 makes it into the nucleus where it activates genes leading to the growth of tumors." In normal skin cells, chemical treatment or UV light prompts the transport of CYLD out into the cytoplasm, they reported. Once there, ...

Stanford snake venom study shows that certain cells may eliminate poison

...Some of the mice they worked with were genetically deficient in mast cells, while others, called wild-type mice... times the dosage of this venom than the mast cell deficient mice could, further indicating that the mast cells were reducing the impact of the venom. To test wh...

Researches discover gene critical for protection against septic-shock-induced death

...eptic peritonitis or endotoxin shock or both. Mice deficient in Nrf2 gene expressed dramatically increased levels of effector molecules (cytokines) that mediate innate immune response, the body's first line of defense. "Sepsis syndrome is like a speeding car with a brake failure. Nrf2 may function like a brake...

Protein found to control tumor growth in certain breast cancers

...ive tumors formed by specific cell lines in immune deficient mice. The evidence uncovered in this study provides new insights into the physiological functions of Nod1 and supports our contention that there is a clear link between Nod1 and estrogen sensitivity in these cells. Our future studies will assess the...

Nobelist discovers antidepressant protein in mouse brain

...ational Institute of Mental Health (NIMH). "Mice deficient in this protein, called p11, display depression-like behaviors, while those with sufficient amounts behave as if they have been treated with antidepressants," explained Paul Greengard, Ph.D., a Rockefeller University neuroscientist who received the 2...

New insight into machinery of immune cells' 'tentacles'

... response to T cell activation. Additionally, mice deficient in Abi proteins have decreased T cell proliferation in response to activating stimuli, found the researchers. "These findings add important new players in the regulatory pathway downstream of Rac," said Pendergast. "And since immune system activatio...

Aggression-related gene weakens brain's impulse control circuits

...though the reasons are unknown, this could reflect deficient pruning ?the withering of unused neuronal connecti...nd memory (hippocampus) hubs. Men with L were also deficient during a task requiring them to inhibit a simple motor response; they failed to activate a part of t...

Lack of a key enzyme dramatically increases resistance to sepsis

...since 1979. The new study showed that caspase-12 deficient mice were resistant to peritonitis and septic shoc...rs after onset, while 60 percent of the caspase-12 deficient mice survived. The deficient mice also showed a significantly lower number of bacterial colony-formi...

Driver of anthrax toxicity could lead to late-stage therapy

...alue, they added. The team found that human cells deficient in the so-called LDL receptor-related protein (LRP6) become resistant to anthrax toxin. Furthermore, antibodies against LRP6 protected cells from anthrax toxicity, reported study authors Wensheng Wei and Stanley Cohen of the Stanford University Schoo...

Boosting newborns' immune responses

...cy. In 1999, Levy discovered that newborns are deficient in a natural antibiotic called bactericidal/permeability-increasing protein (BPI), produced by white blood cells known as neutrophils. Based on this discovery, clinical trials are now underway at the University of Texas Southwestern Medical Center in...

Master genetic switch found for chronic pain

...ntral nervous system changes. The animals rendered deficient in the gene, called Runx1, also showed lack of res...also found that the Runx1-deficient animals showed deficient wiring of certain types of pain neurons. In key experiments, the researchers measured the Runx1-def...

Infant transplant patients resist infections that kill adult AIDS patients

...their thymus removed. As a result the infants were deficient in T cells, the cells depleted in AIDS patients that are crucial to fighting viruses and cancer tumors. The researchers found that over a 10-year-period the infant transplant patients resisted the same infections that often kill adult AIDS patients. ...

Restoring silenced suppressor gene kills lung-cancer cells

... in, the tumor cells of lung-cancer cases that are deficient in this gene, it should have a therapeutic effect." WWOX is a tumor suppressor gene. Tumor suppressor genes safeguard the body by triggering the death of cells that have sustained serious DNA damage before the cells become cancerous. The loss or si...

New vaccine platform may fight infections with causes from influenza to bioterrorism

...a common and very serious infection in people with deficient function of CD4+ T-cells, such as patients with transplanted organs, HIV and children with leukemia. Without normal reservoirs of these particular T-cells that are key to immune responses, these patients are unable to stave off an infection that in m...

Building a better mouse model of lung cancer: FHIT counts

...uman lung cancer. They discovered that while mice deficient in the FHIT gene's protein did not develop lung tu...er parts of the body. The scientists exposed mice deficient in both genes to a second carcinogen, DMN, which is also found in smoke but also in beer, fish meal ...

Research team receives $7.5 million to study cassava

... to cassava ?its roots are low in protein and also deficient in several micronutrients, such as iron, zinc and vitamin A. And once the roots are harvested, certain strains of cassava can produce potentially toxic levels of cyanogens ?substances that induce poisonous cyanide production. "In Africa , improperly...

Weight control protein may yield antiobesity drugs

...for SH2-B in the regulation of blood glucose; mice deficient for the protein develop insulin resistance and type 2 diabetes, they found. The current study shows that SH2-B also regulates energy balance and body weight by enhancing leptin sensitivity in animals, Rui said. Mice lacking a functional copy of the...

Gene loss accelerates aging

...sues. What struck us right away was that these p63 deficient mice were aging prematurely," says Alea Mills of C...e effects of premature aging observed in these p63 deficient mice (image available on request) were hair loss, reduced fitness and body weight, progressive curva...

Muscle repair: Making a good system better, faster; implications for aging, disease

... Koh of UIC said later. The study, entitled "Mice deficient in plasminogen activator inhibitor-1 have improved...ifferences in how normal (wild type, or WT), PAI-1 deficient (null) and uPA null mice recovered from muscle injury. Five days after an injury, PAI-1 null mice ha...

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