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Tag: "deficient" at biology news

Pregnant mom's exposure to flu vaccine kick-starts fetal immune system

...heory that the human neonatal immune system is not deficient or incompetent but, rather, capable of responding to environmental exposures. These conclusions have important implications for determining when immune responses to environmental exposures begin....

DNA-damage test could aid drug development

... with mutant mice created by Samson's lab that are deficient in certain DNA-repair systems. The bone marrow cells derived from these mice, and the cells cultured from that bone marrow, proved more sensitive to the toxic agents than were the cultured cells from normal mice, further confirming the results. Wi...

Blood sugar's manufacture limited by building blocks' supply

...ublished by Cell Press. The study found that mice deficient for KLF15, a member of the so-called Krüppel-like family of transcription factors, become severely lacking in the blood sugar glucose—a primary energy source for the body and the sole source for the brain—after a period of overnight fasting. The rese...

Aspirin discovery may improve cancer treatments

... of eIF2Ą in normal mouse cells, but not in cells deficient in PERK. Aspirin was shown to activate PERK. Moreo...l cells, this did not occur significantly in cells deficient in PERK. Thus PERK plays an important role in the inhibition of protein synthesis by salicylates. ...

Discovery could lead to better control of hemorrhagic fever viruses

... occur in poor rural areas, where people are often deficient in micronutrients, including iron, possibly predisposing them to more severe infection when exposed to the rodents that carry the viruses. Choe's lab is now trying to find the cellular receptor for other viruses that cause hemorrhagic fever in hum...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...kes the housekeeping enzyme hexosaminidase ("hex") deficient and, therefore, has Sandhoff's Disease, a lethal g...to any ethnic group. Both diseases are marked with deficient Hex enzyme functioning and are among a known group of about 50 diseases rooted in the inability to m...

A genetic 'gang of 4' drives spread of breast cancer

...lity of the cells in the lung. They injected cells deficient in the four genes directly into the circulatory system of mice. "When these cells reached the lung capillaries, they just got stuck there," said Massagué. "We concluded that metastatic cells use these same genes to loosen up cells in capillaries, so ...

Gene elevating breast cancer risk also causes prostate cancer

...s later showed that the relevant mutant protein is deficient in its ability to support the kinds of DNA damage responses in which PALB2 normally participates. The mutation was further also investigated in 1,918 specimens from an unselected series of Finnish breast cancer individuals. This study revealed 18 mut...

New cell type identified in cancer development

... One group was comprised of severe combined immune deficient mice, a second group was composed of mice whose immune systems had been knocked out by radiation, but had been partially restored by an infusion of bone marrow cells; and the third group was made up of normal, healthy mice. The results showed that...

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

...r the obese phenotype observed in the EP3 receptor deficient mice is dependent on the lack of EP3 in the centra...n the paper, "Night eating and obesity in the EP3R deficient mouse." ...

Dual gene therapy suppresses lung cancer in preclinical test

...uppressor discovered by the research group that is deficient in most human lung cancers. Each nanoparticle carried one of the two genes. The Cancer Research paper reports that FUS1 works with p53 to force the lung cancer cells to kill themselves - a process known as apoptosis. Further analysis showed th...

How mammals fuel milk production may have implications for cancer

...d to structural abnormalities, they found, mothers deficient for the gene exhibit a disruption of the coordinated metabolic changes that normally occur at the onset of lactation. “The developmental program that prepares the mammary gland for lactation is among the most critical and highly conserved in mamma...

Studies find general mechanism of cellular aging

...archers developed strains of mice that were either deficient in p16INK4a (the gene was deleted, or 'knocked out") or genetically altered to have an excess of the protein to a degree seen in aging. According to Sharpless, islet proliferation persisted in p16INK4a -deficient animals as they aged, "almost as if...

Researchers create mouse lacking key inflammation gene

...the LITAF-positive control mice. Specifically, the deficient mice were more resistant to LPS-induced lethality. "The generation of the macrophage-specific LITAF-deficient animals opens new opportunities for assessing the role of LITAF in inflammation in hopes of designing anti-LITAF drugs for major inflamma...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...25 percent of tumors were in the proximal colon of deficient mice, compared to 60 percent in the control mouse ...for these cancer-causing characteristics. In fact, deficient mice had a decrease in proliferation in colon cells and an increase in apoptosis. The researcher...

Soil nutrition affects carbon sequestration in forests

... levels. Due to land use history, many forests are deficient in soil nutrition, but forest management -- including fertilizing with nitrogen -- can greatly increase growth rate and wood growth responses to elevated atmospheric CO2." The studies took place at a Free Air Carbon Enrichment (FACE) study establi...

Wheat gene may boost foods' nutrient content

...tion estimates that more than 2 billion people are deficient in zinc and iron, and more than 160 million children under the age of five lack an adequate protein supply. The cloned gene, designated GPC-B1 for its effect on Grain Protein Content, accelerates grain maturity and increases grain protein and micro...

Mutant mice show key autism traits

... The researchers also found the mutant mice to be deficient in nest-forming and sexual and maternal behavior. In tests of their reaction to such sensory stimuli as bright environments, the mutant mice showed hyperactivity and increased anxiety. They also showed sporadic seizures. The researchers concluded th...

Increased sensitivity to nerve signals keeps diabetes at bay

...insulin release of otherwise normal mice that were deficient for M3 receptors only in pancreatic beta cells, and in mice that contained an increased number of M3 receptors specifically in beta cells. "We've established an important role for the native M3 receptor in beta cells in maintaining normal insulin re...

Lack of key enzyme associated with development of rare tumor

...e patients' tumors were made up of cells that were deficient in the enzyme PDE11A. This enzyme halts cyclic nucleotide production in adrenal cells as well as in other kinds of cells in the body. Because they lacked PDE11A, the patients' adrenal cells had higher levels of cyclic nucleotides. The researchers ...

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