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Tag: "deficiency" at biology news

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...tegrity of the genome. Studies have suggested that deficiency in cells' capacity for DNA repair contributes to the accumulation of DNA damage and accelerates the genetic changes involved in carcinogenesis. To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterat...

Fox Chase Cancer Center scientists identify immune-system mutation

...Ph.D., discovered mice with severe combined immune deficiency (SCID), a condition that also affects humans. In addition to providing a unique animal model to study the SCID syndrome, SCID mice have become a highly valuable tool for studying the immune system and are now used by scientists worldwide. Kappes' co...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...he Jan. 14, 2005, issue of the journal Cell. Iron deficiency is the most prevalent and severe nutritional disor...prived of oxygen needed for energymetabolism. Iron deficiency causes wide-ranging symptoms from fatigue,weakness and cognitive deficits to serious heart complicat...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...tumors at death. The male rats that had a lifelong deficiency of growth hormone had substantially fewer tumors ?...ed kidney disease. They found that animals with a deficiency in growth hormone initiated after adolescence had up to a 14.6 percent increase in lifespan. All ani...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...y do not get cancers. However, combining the Foxl1 deficiency with an inactive APC gene had drastic outcomes. Th...ation. Additional analysis revealed that the Foxl1 deficiency affected the onset of tumor formation, accelerating them to arise in 1/3rd of the normal time. The a...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...ing the vascular constriction and resulting oxygen deficiency through the restoration of nitric oxide to red cel...ng patients may be explained, in part, by variable deficiency in the processing of nitric oxide," Stamler said. In light of the discovery, the researchers call f...

Iron exporter revealed that may explain common human disorder

... but quickly became anemic after birth due to iron deficiency in the blood. Examination of the animals' intestin...nly in intestinal cells also developed severe iron deficiency anemia, further confirming the protein's role in iron absorption. The findings offer insight into t...

Brain-mapping technique aids understanding of sleep, wakefulness

...helps keep animals awake. In humans, a lack of, or deficiency in, orexin causes narcolepsy, a rare disease in which people uncontrollably fall asleep, have excessive daytime sleepiness and experience sudden muscle weakness called cataplexy. Because orexin-producing neurons play such a key role in regulating sl...

Major breakthrough in the treatment of cancers and infectious diseases

... the viruses causing hepatitis and herpes. NK cell deficiency is associated with a higher frequency of cancers and serious infections. Dr. Veillette's breakthrough demonstrates that a molecule known as EAT-2, present in NK cells, suppresses its killer function. Inhibiting EAT-2 with medications could boost NK c...

Investigating 'brain shrinkage' in alcoholics

...habits in some alcoholics, indicates that thiamine deficiency can contribute to impaired cognition. Cirrhosis of... these factors ?particularly the alcohol, thiamine deficiency and cirrhosis ?are linked and probably contribute in a complex way to cause brain damage." - Both p...

Elderly mice yield clues to the process of growing old

...tations. Using mice genetically altered to have a deficiency in a protein that proofreads mitochondrial DNA and thus accumulate genetic mutations at a higher rate than unaltered mice, the group led by Prolla found evidence that programmed cell death, known as apoptosis, was greatly accelerated. The altered mic...

Muscle repair: Making a good system better, faster; implications for aging, disease

...rkable capacity for regeneration" and self-repair, deficiency in the plasminogen activator inhibitor-1 (PAI-1) a...muscle repair, the UIC-Michigan team reported that deficiency in uPA pretty much eliminated muscle regeneration after injury. Muscles in animals without uPA showe...

Gene for immune deficiency syndromes found

...ular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), repor...unrecognized because of a lack of good tests. IgA deficiency affects 1 in 600 people; CVID is less common but more severe. Children and adults with either condit...

Protein amplification in melanoma is possible drug target

...ular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), repor...unrecognized because of a lack of good tests. IgA deficiency affects 1 in 600 people; CVID is less common but more severe. Children and adults with either condit...

Suppressing growth hormone in early adulthood may prevent cancer

... the current study, Sonntag found that a life-long deficiency of IGF-1 decreased cancer risk by approximately 45 percent and decreased cancer deaths by 12-15 percent. "Besides reducing the incidence of cancer in these rats, we found that a modest suppression of plasma IGF-1 beginning shortly after puberty and ...

Defective Gene Linked to Two Inherited Immune Deficiencies

...e two inherited conditions ?immunoglobulin A (IgA) deficiency and common variable immunodeficiency (CVID). Curre... no specific tests to detect the two disorders. A deficiency of IgA ?an important type of infection-fighting antibody found in tears, saliva and other secretions...

Agreement will speed research on microbicides for women

...e two inherited conditions ?immunoglobulin A (IgA) deficiency and common variable immunodeficiency (CVID). Curre... no specific tests to detect the two disorders. A deficiency of IgA ?an important type of infection-fighting antibody found in tears, saliva and other secretions...

Biologists Crack Genetic Code for Specialized Spider Silk

...e two inherited conditions ?immunoglobulin A (IgA) deficiency and common variable immunodeficiency (CVID). Curre... no specific tests to detect the two disorders. A deficiency of IgA ?an important type of infection-fighting antibody found in tears, saliva and other secretions...

Prenatal exposure to famine increases risk of schizophrenia

...search suggesting a link between fetal nutritional deficiency and schizophrenia, according to a study in the August 3 issue of JAMA, a theme issue on violence and human rights. Schizophrenia is a common form of severe mental illness characterized by thought disorder, hallucinations, and delusions, as well a as...

'Acid rain' and forest mass: Another perspective

... atmospheric deposition of contaminants. Magnesium deficiency was observed in all the adult formations studied. The acceleration of the return of nutrients and the drop in the efficiency of their use is proposed as an explanation of this disorder. Thanks to this investigation, it was concluded that the atmosph...

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